Patents by Inventor Joseph L. Witztum

Joseph L. Witztum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apolipoprotein B-specific monoclonal antibodies produced by two novel hybridomas
    Patent number: 5460947
    Abstract: Two hybridomas that produce receptors containing antibody combining sites that immunoreact with apolipoprotein B-100 are disclosed as are uses for the receptors, compositions and diagnostic systems that include the receptors.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: October 24, 1995
    Assignee: The Scripps Research Institute
    Inventors: Steven Young, Joseph L. Witztum, Linda K. Curtiss
  • Nonnatural apolipoprotein B-100 peptides and apolipoprotein B-100-apolipoprotein A-I fusion peptides
    Patent number: 5408038
    Abstract: Methods and compositions are described for determining the level of low density lipoproteins (LDL) in plasma. Native apoprotein B-100 (apo B-100) present in LDL particles is immunologically mimicked by a polypeptide of the invention. A polypeptide includes an amino acid residue sequence corresponding to a pan epitope region of the target apoprotein. A preferred polypeptide is a fusion protein that simultaneously mimics native apo B-100 and native apo A-I. Improved assay systems and methods for determining HDL and LDL levels in a body fluid sample are also described.
    Type: Grant
    Filed: October 8, 1992
    Date of Patent: April 18, 1995
    Assignee: The Scripps Research Institute
    Inventors: Richard S. Smith, Linda K. Curtiss, Kanaka R. Koduri, Joseph L. Witztum, Stephen G. Young
  • Apolipoprotein B-specific monoclonal antibodies produced by two novel hybridomas
    Patent number: 5330910
    Abstract: Two hybridomas that produce receptors containing antibody combining sites that immunoreact with apolipoprotein B-100 are disclosed as are uses for the receptors, compositions and diagnostic systems that include the receptors.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: July 19, 1994
    Assignee: The Scripps Research Institute
    Inventors: Steven Young, Joseph L. Witztum, Linda K Curtiss
  • Assay method and diagnostic system for determining the ratio of APO B-100 to APO A-I in a blood sample
    Patent number: 4828986
    Abstract: Methods of determining the ratio of apolipoprotein B-100 to apolipoprotein A-I using ELISA techniques in conjunction with monoclonal paratopic molecules are disclosed as are diagnostic systems useful in performing those determinations. Monoclonal paratopic molecules secreted by hybridomas having ATCC accession numbers HB 8742, HB 8746, HB 9200 and HB 9201 are utilized.
    Type: Grant
    Filed: September 29, 1986
    Date of Patent: May 9, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Richard S. Smith, Doreen M. Hogle, Linda K. Curtiss, Joseph L. Witztum, Steven Young
  • Receptors specific for hapten-modified self proteins
    Patent number: 4778752
    Abstract: Epitope-specific reagents in the form of receptors that bind to hapten-modified proteins and do not bind to unmodified proteins, methods of their preparation and use, along with diagnostic systems for measuring the presence and amount of hapten-modified protein in an assayed sample are disclosed. In particular, monoclonal antibodies that bind reduced glycosylated proteins (for example, reductively glucosylated proteins including human plasma lipoproteins), but do not react with non-reduced glycosylated proteins, reduced non-glycosylated proteins or non-reduced non-glycosylated proteins are produced and utilized.
    Type: Grant
    Filed: December 17, 1986
    Date of Patent: October 18, 1988
    Assignee: Scripps Clinic and Research Foundation
    Inventors: Linda K. Curtiss, Joseph L. Witztum