Patents by Inventor Joseph Lacey

Joseph Lacey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250020599
    Abstract: A system comprises an energy source and detector. The energy source is configured to emit energy from a focal spot. The detector comprises an array of pixels. Each of the pixels of the array of pixels has a centerline extending longitudinally through the pixel. The centerline of each pixel is focally aligned with the focal spot of the energy source. Each of the pixels receives selected amounts of the energy from the energy source that have passed through an object.
    Type: Application
    Filed: July 13, 2023
    Publication date: January 16, 2025
    Inventors: Matthew Edward Dragovich, Joseph Lacey
  • Publication number: 20240336886
    Abstract: A baffle (130) configured to be disposed in a cell culture vessel is provided. The cell culture vessel (100) may comprise a vessel body (101) comprising a bottom wall (110) and a plurality of side walls (107) that define a cell culture chamber, the bottom wall comprising a cell culture surface (111). The baffle (130) may be configured to be disposed parallel to the cell culture surface (111) within the vessel body, the baffle comprising a first baffle crossbar (133) extending across a length of the cell culture surface; a second baffle crossbar intersecting (135) the first baffle crossbar; and a third crossbar disposed (137) at an end of the first baffle crossbar.
    Type: Application
    Filed: July 29, 2022
    Publication date: October 10, 2024
    Inventors: Thomas Albert Cloutier, William Joseph Lacey, Ana Maria del Pilar Pardo, Allison Jean Tanner
  • Publication number: 20240301336
    Abstract: A protective carrier for a microcavity vessel is provided. The protective carrier comprises a substantially flat rigid plate comprising a top surface and a bottom surface. A flange disposed around at least a portion of a perimeter of the rigid plate, the flange extending from the top surface of the rigid plate. One or more ribs disposed on the bottom surface of the rigid plate. A protective microcavity vessel carrier system is provided that comprises a microcavity vessel comprising a microcavity substrate on a bottom surface; and a protective carrier. The microcavity vessel may be a microcavity flask, microcavity plate such as an open well reservoir plate, microcavity bioreactor, or a stacked 3D microcavity culture vessel.
    Type: Application
    Filed: June 14, 2022
    Publication date: September 12, 2024
    Inventors: Thomas Albert Cloutier, William Joseph Lacey, Ana Maria del Pilar Pardo, Allison Jean Tanner
  • Publication number: 20240091778
    Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.
    Type: Application
    Filed: November 30, 2023
    Publication date: March 21, 2024
    Inventors: William Joseph Lacey, Gregory Roger Martin, Ana Maria del Pilar Pardo, Allison Jean Tanner
  • Patent number: 11857970
    Abstract: A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: January 2, 2024
    Assignee: CORNING INCORPORATED
    Inventors: William Joseph Lacey, Gregory Roger Martin, Ana Maria del Pilar Pardo, Allison Jean Tanner
  • Publication number: 20230416664
    Abstract: Cell culture devices comprise a frame comprising an open well disposed therein and a fluid inlet area in communication with the open well. The open well comprises a top opening, a bottom plate comprising a microcavity substrate, the bottom plate defining a major surface, and one or more sidewalls extending from the bottom plate to the top opening. The microcavity substrate comprises a plurality of microcavities, and each microcavity is configured such that cells cultured in the well form a spheroid. The cell culture device may be a reservoir open well microcavity plate used for spheroid cell culture.
    Type: Application
    Filed: November 17, 2021
    Publication date: December 28, 2023
    Inventors: William Joseph Lacey, Allison Jean Tanner
  • Patent number: 11833302
    Abstract: An anesthesia vaporizer system includes a vaporizer reservoir forming a sump chamber that contains liquid anesthetic agent and a fill chamber isolated from the sump chamber configured to receive liquid anesthetic agent from a refill container. A piston is in the sump chamber configured to maintain a constant force on the liquid anesthetic agent in the sump chamber, and a transfer valve is configured to permit the liquid anesthetic agent to flow from the fill chamber to the sump chamber. The vaporizer reservoir has an outlet port that delivers the liquid anesthetic agent from the sump chamber to a vaporizing system that vaporizes the liquid anesthetic agent for delivery to a patient.
    Type: Grant
    Filed: June 25, 2021
    Date of Patent: December 5, 2023
    Assignee: General Electric Company
    Inventors: Thomas Bender, II, Joseph Lacey, Russell Kuzelka, David Wahl
  • Publication number: 20230357686
    Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
    Type: Application
    Filed: July 7, 2023
    Publication date: November 9, 2023
    Inventors: William Joseph Lacey, Gregory Roger Martin, Allison Jean Tanner
  • Publication number: 20230276791
    Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.
    Type: Application
    Filed: May 12, 2023
    Publication date: September 7, 2023
    Inventors: William Joseph Lacey, Gregory Roger Martin, Allison Jean Tanner
  • Patent number: 11732227
    Abstract: A cell culture vessel includes a vessel body, support columns, and a stabilizer device. The vessel body defines a cell culture chamber enclosed between a bottom wall and a top wall. The support column is within the cell culture chamber and extends between the top wall and the bottom wall. The stabilizer device covers a width and length of the cell culture chamber and has a column engaging structure that is sized to slidingly engage the support column such that the stabilizer device is movable along the support column as a liquid culture medium is received in the cell culture chamber. The support column guides the stabilizer device along a length of the support column as the stabilizer device rises with rising liquid level in the cell culture chamber during a liquid culture medium filling operation.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: August 22, 2023
    Assignee: CORNING INCORPORATED
    Inventors: William Joseph Lacey, Gregory Roger Martin, Allison Jean Tanner
  • Publication number: 20230257690
    Abstract: A cell culture system for culturing cells is provided. The cell culture system including a cell culture vessel with a cell culture chamber for culturing cells, an inlet through which liquid can flow for filling the cell culture vessel, and an outlet through which fluid can exit the cell culture vessel. The system also includes at least one fill sensor arranged to detect liquid within the cell culture vessel reaching a fill level at a predetermined position of the cell culture vessel during filling of the cell culture vessel, where the at least one fill sensor can generate a detection signal when liquid within the cell culture vessel reaches the fill level. Also included is an actuator to change an orientation of the cell culture vessel in response to the detection signal.
    Type: Application
    Filed: July 28, 2021
    Publication date: August 17, 2023
    Inventors: Scott Matthew Bennett, Thomas Albert Cloutier, William Joseph Lacey, Gregory Roger Martin, Allison Jean Tanner
  • Patent number: 11684064
    Abstract: Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: June 27, 2023
    Assignee: CORNING INCORPORATED
    Inventors: William Joseph Lacey, Gregory Roger Martin, Allison Jean Tanner
  • Publication number: 20220411738
    Abstract: A cell culture system is provided that includes a cell culture vessel having an interior cavity to house a cell culture substrate in a cell culture space, and at least one port for at least one of fluid inlet to the interior cavity and fluid outlet from the interior cavity. The system further includes a piston having a distal end disposed in the cell culture vessel above the cell culture space, the distal end of the piston being sealed with an airtight seal within the interior cavity. The system also includes a driver coupled to the piston to move the piston so as to increase and decrease a distance between the distal end and the cell culture space. The driver can pressurize the interior cavity via actuation of the piston to harvest cells from the cell culture space through the at least one port.
    Type: Application
    Filed: November 4, 2020
    Publication date: December 29, 2022
    Inventors: Vasiliy Nikolaevich Goral, Kathleen Anne Krebs, William Joseph Lacey, Mackenzie Anna Maloney, Todd Marshall Wetherill
  • Publication number: 20220400667
    Abstract: Vial assemblies comprising a tubular body and a flexible bottom or flexible liner are described herein, wherein the flexible bottom or liner is configured to compress at least partially upon the application of force. Methods for storing and removing frozen samples from such vial assemblies are also described herein.
    Type: Application
    Filed: August 26, 2022
    Publication date: December 22, 2022
    Inventors: John Wilfred Coddaire, William Joseph Lacey, Gregory Roger Martin, Michael Kurt Schaefer, Paul Michael Szlosek, Allison Jean Tanner
  • Publication number: 20220290080
    Abstract: A cell culture assembly includes a film defining a plurality of wells extending into the film, where each well of the plurality of wells defines a perimeter extending around the well, the plurality of wells defines an outer perimeter extending around the plurality of wells and extending between the perimeters of adjacent wells of the plurality of wells, and the outer perimeter extending around the plurality of wells defines a wave shape, and a sidewall member coupled to the film, where at least a portion of the sidewall member is oriented transverse to the film, the sidewall member including an engagement portion defining a wave shape that is complementary with the outer perimeter of the plurality of wells.
    Type: Application
    Filed: August 11, 2020
    Publication date: September 15, 2022
    Inventor: William Joseph Lacey
  • Publication number: 20220016385
    Abstract: A system for tracking anesthetic agent in a vaporizer reservoir can include a mass flow sensor configured to measure a flow rate entering or exiting a vaporizer chamber, a gas pressure sensor configured to measure a pressure of a mixed gas provided from the vaporizer chamber, and a processor to calculate a remaining agent time based on at least the gas flow rate, the pressure of the mixed gas, and an anesthetic concentration in the mixed gas. The processor can also provide the remaining agent time for display to a clinician.
    Type: Application
    Filed: September 30, 2021
    Publication date: January 20, 2022
    Inventors: Julie Anne Mills, Joseph Lacey, Thomas Bender, II, Russell Kuzelka, David Michael Wahl
  • Publication number: 20220016634
    Abstract: Various implementations of a pipette tip system are disclosed having a number of innovative features. In one implementation, a pipette tip tray includes a support plate and one or more sleeves extending downward from the bottom of the support plate. The sleeves can be configured to increase the stability of pipette tips stored in the tray. In another implementation, a pipette tip rack includes a rack base having one or more support walls extending underneath a pipette tip tray having downward extending sleeves. The thickness of the sidewalls of the sleeves can be reduced in the area of the support walls so that the support walls can reach the bottom of the support plate. In another implementation, a pipette tip rack includes a cover having a cushioning layer on the bottom of the cover that contacts the top of the pipette tips and stabilizes them during handling and transport.
    Type: Application
    Filed: November 12, 2019
    Publication date: January 20, 2022
    Inventors: William Joseph Lacey, Paul Kevin Seeto
  • Patent number: 11154686
    Abstract: A system for tracking anesthetic agent in a vaporizer reservoir includes a mass flow sensor configured to measure a flow rate entering or exiting a vaporizer chamber, a gas pressure sensor configured to measure a pressure of a mixed gas provided from the vaporizer chamber, a gas temperature sensor configured to measure a temperature of the mixed gas provided from the vaporizer chamber, and an agent time module executable on a processor. The agent time module is configured to calculate a remaining agent time based on at least the gas flow rate, the pressure of the mixed gas, the temperature of the mixed gas, and an anesthetic concentration in the mixed gas. The remaining agent time is then provided for display on a display device.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: October 26, 2021
    Assignee: General Electric Company
    Inventors: Julie Anne Mills, Thomas Bender, II, Joseph Lacey, Russell Kuzelka, David Michael Wahl
  • Publication number: 20210322694
    Abstract: An anesthesia vaporizer system includes a vaporizer reservoir forming a sump chamber that contains liquid anesthetic agent and a fill chamber isolated from the sump chamber configured to receive liquid anesthetic agent from a refill container. A piston is in the sump chamber configured to maintain a constant force on the liquid anesthetic agent in the sump chamber, and a transfer valve is configured to permit the liquid anesthetic agent to flow from the fill chamber to the sump chamber. The vaporizer reservoir has an outlet port that delivers the liquid anesthetic agent from the sump chamber to a vaporizing system that vaporizes the liquid anesthetic agent for delivery to a patient.
    Type: Application
    Filed: June 25, 2021
    Publication date: October 21, 2021
    Applicant: General Electric Company
    Inventors: Thomas Bender, II, Joseph Lacey, Russell Kuzelka, David Wahl
  • Patent number: 11136540
    Abstract: A flask assembly that includes: an Erlenmeyer flask; and a liner bag comprising a single opening the bag sized to fit within the flask and having a thickness from about 0.0254 mm to about 0.508 mm. The liner bag is configured for cell culturing and ease of insertion of the bag into the flask. In addition, the liner bag comprises a gas-permeable, polymeric material. Further, the liner bag can include a pocket adapted to receive a removable flask insertion element and/or at least one foldable seam configured to facilitate insertion of the bag into the flask. The liner bag can also include a vent having a gas permeability that is greater than the gas permeability of the gas-permeable, polymeric material employed in the balance of the bag.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 5, 2021
    Assignee: Corning Incorporated
    Inventor: William Joseph Lacey