Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Systems, methods, and computer-readable media are disclosed for estimating impressions for a digital out of home (DOOH) advertising spaces (e.g., digital billboards and screens). A DOOH advertising system may determine the location of relevant DOOH advertising spaces and the location of certain consumers with known attributes and a known location. Based on this information the DOOH advertising system may estimate a number of impressions for a given DOOH advertising space and a given consumer segment associated with attributes of consumers within a certain distance from the DOOH advertising space. Using this information, the DOOH advertising spaces having the highest estimated impressions for a given consumer segment may be identified.

Abstract: A method for rotatable selection of sites for cannulation of a subcutaneous vascular access vessel comprises the step of providing a template defining an opening for a plurality of zones, each of the plurality of zones configured for receiving a plurality of simultaneous cannulations accessing the vascular access vessel. The outer surface of the template is marked, the marking defining each of the plurality of zones for use as cannulation sites along the vascular access vessel. The template is positioned on the skin of the patient adjacent the subcutaneous vascular access vessel such that the opening aligns with the vascular access vessel, and the marking is used for selecting a first zone for a cannulation site into the vascular access vessel such that the cannulation site in the first zone is spaced from and not adjacent to a second zone used for cannulation immediately previously to the first zone.

Abstract: An apparatus is provided for rotatable selection of sites for cannulation with a needle along a subcutaneous vascular access vessel. The cannulation site selection apparatus comprises a template having an inner surface and an outer surface, and a plurality of visible markings on the outer surface of the template. The template is adapted to be disposed adjacent the subcutaneous vascular access vessel such that the markings align with the cannulation sites along the vascular access vessel for selecting a site for cannulation with a needle into the vascular access vessel.

Abstract: A system for determining the profile of a laser beam includes a detector having a thermochromic liquid crystal film (TLCF) in thermal communication with a heat spreader and a thermoelectric cooler. The liquid crystal film has a thermochromic response such that heating of the film by a received laser beam creates a detectable color response at the film. The system also includes an image sensor and a controller configured to output an operating current for the TEC and receive images from the sensor. The system can selectively vary the temperature set point of the TEC to change the steady state temperature of the TLCF to examine the full intensity profile of the received beam even when the temperature response bandwidth of the TLCF is too narrow to display the full beam profile in a single color spot.

Abstract: Systems and methods for aligning an optical fiber are provided herein. The method may include providing an optical fiber having a first end and a second end, where the first end of the optical fiber has a predefined manufacturing property. For example, the predefined manufacturing property of the first end of the optical fiber may include a predefined cleave angle. The method may also include positioning the optical fiber such that the first end of the optical fiber faces a microlens array (MLA) alignment system. In an example embodiment, the MLA alignment system may include a tilt sensing device and a position sensing device. The method may also include emitting a light beam from the first end of the optical fiber toward the MLA alignment system.

Abstract: Systems and methods for measuring a cleave angle of an optical fiber using a cleave angle measurement system is provided herein. In an aspect, a method for measuring a cleave angle of an optical fiber may include providing a cleave angle measurement system. The cleave angle measurement system may include an optical fiber channel, an image sensor, and a light source. The method may include placing an optical fiber having a cleaved end into the optical fiber channel. The method may include determining an optical center of the image sensor. The method may include reflecting light transmitted by the light source off of the cleaved end of the optical fiber and detecting, by the image sensor, light reflected off of the cleaved end of the optical fiber. The cleave angle of the optical fiber may be determined based on the light reflected off of the cleaved end.

Abstract: Methods and systems that can be used for aligning and positioning of an optical fiber are provided herein. For example, an optical fiber alignment and positioning system including a vacuum stage may be provided. The vacuum stage may include a vacuum inlet operable to be in fluid communication with a vacuum source and one or more passages extending through the vacuum stage. The vacuum stage may include an optical fiber channel. A plurality of vacuum ports may pass through the optical fiber channel. The optical fiber channel may include a directional friction surface. The directional friction surface may include a first friction factor in a first direction and a second friction factor in a second direction. The directional friction surface may contact a portion of the optical fiber and may allow movement in the second direction but resist movement of the optical fiber in the first direction.

Abstract: Various embodiments and methods relating to an optical fiber alignment and splicing system are described herein. The optical fiber alignment and splicing system includes a first rotation stage having a first central axis, a first end, and a second end, and a second rotation stage having a second central axis, a third end, and a fourth end. The first central axis extends from the first end to the second end of the first rotation stage, and the second central axis extends from the third end to the fourth end. The first rotation stage includes a first optical fiber channel extending from the first end of the first rotation stage to the second end of the first rotation stage, and the second rotation stage includes a second optical fiber channel extending from the third end of the second rotation stage to the fourth end of the second rotation stage.

Abstract: Various embodiments and method relating to an optical fiber curvature measurement system are described herein. The optical fiber curvature measurement system includes a controller and a rotation stage. The rotation stage includes a central axis, a first end, and a second end. The central axis extends from the first end to the second end of the rotation stage. The rotation stage includes an optical fiber channel extending from the first end of the rotation stage to the second end of the rotation stage. The rotation stage is operationally coupled with the controller and configured to rotate about the central axis of the rotation stage. An optical fiber may be positioned within the optical fiber channel. The optical fiber curvature measurement system also includes a light source positioned to emit light onto the optical fiber channel at an oblique angle from the central axis of the rotation stage.

Abstract: Various embodiments and methods related to an optical fiber alignment system are provided herein. The optical fiber alignment system includes a controller and a rotation stage having a central axis, a first end, and a second end. The central axis extends from the first end to the second end of the rotation stage. The rotation stage includes an optical fiber channel extending from the first end of the rotation stage to the second end of the rotation stage and may be operationally coupled with the controller. The rotation stage is configured to rotate about the central axis of the rotation stage. The optical fiber alignment system includes a light source positioned to emit light onto the optical fiber channel at an oblique angle from the central axis of the rotation stage. The optical fiber alignment system includes an image sensor positioned adjacent to the second end of the rotation stage.

Abstract: A system for determining the profile of a laser beam includes a detector having a thermochromic liquid crystal film (TLCF) in thermal communication with a heat spreader and a thermoelectric cooler. The liquid crystal film has a thermochromic response such that heating of the film by a received laser beam creates a detectable color response at the film. The system also includes an image sensor and a controller configured to output an operating current for the TEC and receive images from the sensor. The system can selectively vary the temperature set point of the TEC to change the steady state temperature of the TLCF to examine the full intensity profile of the received beam even when the temperature response bandwidth of the TLCF is too narrow to display the full beam profile in a single color spot.

Abstract: A method for printing a three-dimensional part includes receiving a sequence of part layer patterns together with first and second complementary mask patterns. For each part layer pattern in the sequence of part layer patterns, a mask pattern is selected according to the layer number of the part layer pattern, wherein the first mask pattern is selected for odd layer numbers and the second mask pattern is selected for even layer numbers. A masked part layer is formed by applying the selected mask pattern to the part layer pattern. A developed part layer is formed using an electrophotography engine, and the developed part layer is transfused together to previously-printed part layers to form a printed part layer of the three-dimensional part.

Abstract: A method for printing a three-dimensional part includes receiving a sequence of part layer patterns together with first and second complementary mask patterns. For each part layer pattern in the sequence of part layer patterns, a mask pattern is selected according to the layer number of the part layer pattern, wherein the first mask pattern is selected for odd layer numbers and the second mask pattern is selected for even layer numbers. A masked part layer is formed by applying the selected mask pattern to the part layer pattern. A developed part layer is formed using an electrophotography engine, and the developed part layer is transfused together to previously-printed part layers to form a printed part layer of the three-dimensional part.

Abstract: A disposable staining system is provided including an insertable module configured to receive a biological sample therein, the insertable module including a well in which the biological sample is positioned; and a staining cartridge configured to receive the insertable module including the biological sample therein, the insertable module being positioned in the staining cartridge. The insertable module has first and second inclined planes on opposing sides of an upper surface of the insertable module. A sled configured to receive the insertable module has corresponding first and second inclined planes on a bottom surface thereof. The first and second inclined planes of the insertable module and the first and second inclined planes of the sled are configured to transform horizontal movement of the insertable module into the staining cartridge into a vertical movement of the sled such that the sled is pushed upward.

Abstract: A system for providing a map-like interface comprises a plurality of sets of image data, each set of image data having associated location and resolution level data, wherein a first set of image data comprises a first associated location and a first resolution level, and a second set of image data comprises the first associated location and a second resolution level. A processor configured to receive the first set of image data and the second set of image data and to generate one or more user controls that allow a user to selectively display the first of image data with some, all or none of the second set of image data.

Abstract: A system for providing a map-like interface comprises a plurality of sets of image data, each set of image data having associated location and resolution level data, wherein a first set of image data comprises a first associated location and a first resolution level, and a second set of image data comprises the first associated location and a second resolution level. A processor configured to receive the first set of image data and the second set of image data and to generate one or more user controls that allow a user to selectively display the first of image data with some, all or none of the second set of image data.