Patents by Inventor Joseph Lein

Joseph Lein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives
    Patent number: 4981789
    Abstract: A process for the one-step conversion of cephalosporin C and derivatives thereof to the corresponding 7-aminocephalosporanic acid and derivatives comprising treating said cephalosporin C and derivatives with a cephalosporin C amidase derived from Arthrobacter viscosus ATCC 53594, or from any cephalosporin C amidase producing, or potentially producing descendants thereof, or from any expression of the genetic material of said Arthrobacter viscosus ATCC 53594, or any cephalosporin C amidase producing, or potentially producing descendants thereof.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: January 1, 1991
    Assignee: Merck & Co., Inc.
    Inventor: Joseph Lein
  • Antibiotics, neoviridogriseins, and their method of production
    Patent number: 4536397
    Abstract: A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.
    Type: Grant
    Filed: October 31, 1983
    Date of Patent: August 20, 1985
    Assignees: Sanraku-Ocean Co., Ltd., Panlabs, Inc.
    Inventors: Yasushi Okumura, Kazuhiko Okamura, Yasuo Fugakawa, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Antibiotics, neoviridogriseins, and their method of production
    Patent number: 4456592
    Abstract: A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.
    Type: Grant
    Filed: December 23, 1981
    Date of Patent: June 26, 1984
    Assignees: Sanraku-Ocean Co., Panlabs Inc.
    Inventors: Yasushi Okumura, Kazuhiko Okamura, Yasuo Fugakawa, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Antibiotics and derivatives thereof having .beta.-lactamase inhibitory activity and production thereof
    Patent number: 4368203
    Abstract: A novel antibiotic substance of the formula ##STR1## wherein R.sub.1 is CH.sub.3 and R.sub.2 is --CH.sub.2 --CH.sub.2 -- or R.sub.1 is H and R.sub.2 is --CH.dbd.CH--; and R.sub.3 represents hydrogen, lower alkyl or triphenylmethyl,and including the salts of the compound of formula (I) wherein R.sub.3 is hydrogen, said antibiotic substance having strong antibiotic activity and .beta.-lactamase inhibiting effect, and a method for producing the same by aerobic cultivation of Streptomyces A271.
    Type: Grant
    Filed: October 10, 1978
    Date of Patent: January 11, 1983
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Streptomyces culture
    Patent number: 4355112
    Abstract: A group of novel depsipeptide antibiotics, neoviridogriseins I, II and III are produced by fermentation of Streptomyces sp. P8648 (FERM-P 3562; ATCC 31289). The antibiotics are highly active against Gram-positive bacteria and mycoplasmas.
    Type: Grant
    Filed: June 6, 1977
    Date of Patent: October 19, 1982
    Assignees: Sanraku-Ocean Co., Ltd., Panlabs, Inc.
    Inventors: Yasushi Okumura, Kazuhiko Okamura, Yasuo Fugakawa, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein
  • Antibiotic PS-5 and derivatives having .beta.-lactamase inhibitory activity and production thereof
    Patent number: 4318916
    Abstract: A novel antibiotic substance and derivatives thereof, having strong antibiotic activity and .beta.-lactamase inhibiting effect and a method for producing the same by aerobic cultivation of Streptomyces A 271.
    Type: Grant
    Filed: March 2, 1978
    Date of Patent: March 9, 1982
    Assignee: Sanraku-Ocean Co., Ltd.
    Inventors: Kazuhiko Okamura, Shoji Hirata, Yasushi Okumura, Yasuo Fukagawa, Yasutaka Shimauchi, Tomoyuki Ishikura, Kageaki Kouno, Joseph Lein