Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: The systems and methods, in one embodiment, include a convolutional neural network (CNN) model trained by a modified version of the CycleGAN process. The CNN filters ultrasound images generated by a handheld ultrasound device to generate images that are perceptually similar to images generated by a cart-based ultrasound device in terms of quality. The resulting images look sharper and less noisy compared to the original inputs. The invention is a tool within the actions menu of a mobile app. When the tool is open, users can turn filtering on and off. The users will turn filtering on to reduce noise so they can reach the right scanning spot faster. After which because of body habitus, still there might be some noise that this tool can clean up. The user can then decide to have the filtering on or off during the diagnostic process.

Abstract: The present invention relates to Compounds of Formula I and Ia and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, X, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I or Ia, and methods of using the compounds of Formula I or Ia for treating or preventing HIV infection in a subject.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: A flexible container has a bag body and a sealing portion at the upper end of the bag body's sidewalls. The sealing portion includes a strip and a groove which are relatively arranged on the inner side of the sealing portion. The strip has a convex mushroom-shaped cross-section, and the groove has a concave mushroom-shaped cross-section. The strip and groove interlock by an interference snap fit connection. The ends of the strip and groove transition from the mushroom-shaped cross-section to a rectangular-shaped cross-section which also snap fit together. The mushroom-shaped cross-section in the middle portion of the strip and groove create a sealing portion that is easy to seal and difficult to open. To help open the sealing portion, tabs extend up from the bag body's sidewalls. There is a cross-sectional transition design near the end, and the transitional shape can increase the sealing force to optimize the anti-leak effect.

Abstract: A transaction record is created showing a purchase transaction of a customer. A CV profile showing a list of items in the transaction obtained from images is also obtained. The items in the transaction record are compared to items on the list. When there is a discrepancy, an action to take is determined.

Abstract: Compositions and methods are described for the delivery of a fully human post-translationally modified therapeutic monoclonal antibody that binds to CGRP or CGRP receptor to a human subject for the treatment or prevention of migraines and cluster headaches. The antibodies may be delivered by gene therapy vectors, particularly rAAV vectors. Also provided are dual transgene constructs for the delivery of anti-CGRP and anti-CGRP receptor antibodies or antigen binding fragments thereof.

Abstract: A system including one or more processors and one or more non-transitory computer-readable media storing computing instructions that, when executed on the one or more processors, perform certain acts. The acts can include obtaining an original load design for loading a trailer to deliver stacks of pallets to physical stores. The load design specifies a respective floor spot assignment for each of the stacks. The original load design satisfies center-of-gravity constraints. The acts also can include generating fluid groups of the stacks to form an initial fluid grouping. The acts additionally can include determining that the fluid groups do not collectively satisfy the center-of-gravity constraints. The acts further can include until the fluid groups collectively satisfy the center-of-gravity constraints, repeatedly determining one or more infeasible groups from the fluid groups, and adjusting at least one of the one or more infeasible groups to update the fluid groups.

Abstract: The present disclosure provides macrocyclic compounds inspired by the immunophilin ligand family of natural products FK506 and rapamycin. The generation of a Rapafucin library of macrocyles that contain FK506 and rapamycin binding domains should have great potential as new leads for developing drugs to be used for treating diseases.

Abstract: A ceiling fan has blades spaced apart circumferentially about and extending outward radially from a rotating component of a motor. The blades include upper blades and lower blades. Each lower blade is between and extends below a pair of adjacent upper blades. The motor, when activated, rotates the rotating component, concurrently rotating the upper blades and the lower blades in the same rotational direction. Each of the upper blades leading an adjacent one of the lower blades is configured to generate and direct an air current rearwardly and downwardly therefrom in front of the adjacent one of the lower blades and each of the lower blades trailing an adjacent one of the upper blades is configured to intercept the air current from the adjacent one of the upper blades and accelerate it rearwardly and downwardly therefrom, when the motor is activated.

Abstract: The present disclosure includes edge defect detection via image analytics. A method includes identifying an image of an edge of a susceptor pocket formed by a susceptor of a substrate processing system. The method further includes predicting, based on the image, whether property values of the edge of the susceptor meet threshold values. The method further includes, responsive to the property values of the edge meeting threshold values, causing performance of a corrective action associated with the susceptor.

Abstract: An artificial intelligence-based system and method for automatically generating and adjusting tags associated with one or more UI/UX related components or features is provided. Analysis may be performed on the data collected by the one or more tags so that design change recommendations can be dynamically recommended and/or implemented. When design changes are implemented, the system may automatically reconfigure or adjust all relevant tags. The AI-based system may be a standalone platform or may be incorporated into existing UI/UX programs.

Abstract: A system, method, and computer-program product includes displaying a plurality of factor-setting user interface (UI) control elements configured to receive an input of characters for specifying a set of design of experiment factors for creating a design of experiment (DOE), displaying a plurality of factor type UI control elements configured to receive input for specifying a factor type of a plurality of factor types, displaying a plurality of dynamic rows of editable UI control elements configured to receive inputs of experimental values for the set of DOE factors, and displaying a composite factor UI control component configured to receive inputs for generating one or more control signals that add or remove one or more DOE factors of the set of DOE factors.

Abstract: A method of plugging channels of a honeycomb body and a honeycomb body including plugged channels. The method includes applying a shear force to a plugging mixture including a plurality of inorganic particles, clay, and a liquid vehicle to alter the viscosity of the plugging mixture from a first viscosity prior to the vibrating to a second viscosity which is less than the first viscosity. A honeycomb body is placed into contact with the plugging mixture such that a portion of the plugging mixture having the second viscosity flows into the plurality of channels. Application of the shear force is stopped or reduced to increase the viscosity of the portion of the plugging mixture in the plurality of channels to greater than the first viscosity.

Abstract: A virtual 3D display for a motor vehicle includes a substrate and a flexible display positioned on the substrate. The flexible display is rollable and bendable within a cabin of the motor vehicle.

Abstract: Optimistic concurrency may be implemented for multiple writers to a database. Writes to a database from different writers may succeed unless a conflict is detected at the data store for the database. For detected conflicts, a request to resolve the conflict between writes may be submitted to a primary writer, which may determine and provide a resolution of the conflict to the conflicting writers. The data store may then be updated to commit the selected write identified by the resolution of the conflict.

Abstract: An engine consumes fuel and air to generate an exhaust gas stream. An exhaust system channels the exhaust gas stream from the engine to a tailpipe. An aftertreatment system is included in the exhaust system and includes a catalyst. An exhaust throttle valve is disposed in the exhaust system downstream from the aftertreatment system. An actuator controls an amount of air pumped through the engine. A controller operates the exhaust throttle valve and/or the actuator to control emissions from the exhaust system during a cold start and following a deceleration fuel cutoff event.

Abstract: A semiconductor package includes a semiconductor substrate forming a cavity and a redistribution layer on a first side of the semiconductor substrate, the redistribution layer forming die contacts within the cavity and a set of terminals for the semiconductor package opposite the semiconductor substrate. The redistribution layer electrically connects one or more of the die contacts to the set of terminals. The semiconductor package further includes a semiconductor die including die terminals within the cavity with the die terminals electrically coupled to the die contacts within the cavity.

Abstract: In some examples, a method for manufacturing a semiconductor package comprises coupling a photoresist layer to a non-device side of a semiconductor wafer, the semiconductor wafer having a device side, first and second circuits formed in the device side and separated by a scribe street, a test device positioned in the scribe street. The method also comprises coupling a tape to the device side of the semiconductor wafer. The method also comprises performing a photolithographic process to form an opening in the photoresist layer and plasma etching through the semiconductor wafer by way of the opening in the photoresist layer to produce first and second semiconductor dies having the first and second circuits, respectively. The method also comprises removing the tape from device sides of the first and second semiconductor dies, wherein removing the tape includes removing the test device. The method also comprises coupling the first circuit of the first semiconductor die to a conductive member.