Abstract: In various aspects, present disclosure is directed to methods, devices and systems whereby one or more low viscosity fluids may be introduced into a catheter and whereby the one or more low viscosity fluids may be converted into a high viscosity fluid in the catheter, which high viscosity fluid may be delivered from an exit port of the catheter.

Abstract: Compositions and methods useful in treating dermatological disorders are described. The methods include applying to the skin a composition comprising a reactive reinforcing component and a cross-linking component, wherein the cross-linking component facilitates a reaction to form a film in situ on the skin.

Abstract: Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up.

Abstract: In various aspects, present disclosure is directed to methods, devices and systems whereby one or more low viscosity fluids may be introduced into a catheter and whereby the one or more low viscosity fluids may be converted into a high viscosity fluid in the catheter, which high viscosity fluid may be delivered from an exit port of the catheter.

Abstract: The present technology relates to composites, apparatuses, systems, and methods that are based on a photocurable composite useful for stabilizing, supporting, or otherwise healing an injured limb. The photocurable composite includes a light-curable resin and a filler material, where the light-curable resin includes about 50 vol % to about 99 vol % (based on the volume of the light-curable resin) of an acrylate-functionalized oligomer, wherein the backbone of the oligomer comprises a polyurethane, a polyether, a polyester, or a combination of any two or more thereof; about 1 vol % to about 50 vol % of a radical-reactive diluent; about 0.001 vol % to about 2 vol % of a photoinitiator; and optionally about 0.05 to about 25 vol % of a surface cure protection agent.

Abstract: Compositions and methods useful for delivering an agent to a subject are described. The methods include applying to the subject's skin a composition comprising a reactive reinforcing component, a cross-linking component, and one or more agents, wherein the cross-linking component catalyzes an in situ reaction on the skin, thereby delivering the agent to the subject.

Abstract: Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.

Abstract: Provided are therapeutic formulations and methods of use thereof.

Abstract: Provided are body corrective cosmetic formulations and methods of use thereof.

Abstract: Provided are body corrective cosmetic formulations and methods of use thereof.

Abstract: The present disclosure is directed to moisture curing formulations as well as articles, devices, systems, kits and methods based on the same.

Abstract: According to one aspect of the invention, multicomponent fiber comprising (a) a polymeric core that comprises a core-forming polymer and (b) a polymeric sheath that comprises a hydrophilic polymer, wherein the core-forming fiber is more hydrophobic than the hydrophilic polymer and wherein the polymeric core, the polymeric sheath, or both, further comprises a hydrophilic excipient material. Other aspects of the present invention pertain to methods of forming such multicomponent fibers. Still other aspects of the present invention pertain to meshes and other articles that are formed using the multicomponent fibers.

Abstract: Compositions and methods of treating conditions of compromised skin hairier function are described.

Abstract: Systems and method for treating aneurysms are provided which utilize formulations that form polymer foams in situ. The formulations generally have a buoyancy greater than or less than blood, and either float to the top of the aneurysm and foam from the top down or sink to the bottom and foam from the bottom up.

Abstract: Provided are therapeutic formulations and methods of use thereof.

Abstract: Provided are body corrective cosmetic formulations and methods of use thereof.

Abstract: This invention relates to compositions and methods useful in treating dermatological disorders. In particular, the methods include applying a composition that includes a reactive reinforcing component; and a cross-linking component; in which the cross-linking component facilitates in situ cross-linking of the reactive reinforcing component, such that a film is formed on skin, thereby treating the dermatological disorder.

Abstract: The present invention provides durable, natural looking, non-invasive compositions that exhibit desired aesthetic qualities. Specifically, the compositions can be used for therapeutic treatments, including treatments of wounds and headaches. The invention pertains, at least in part, to therapeutic formulations for application to the skin that comprise a) a reactive reinforcing component; and b) a cross-linking component; in which the cross-linking component facilitates in situ formation of a film over the skin.

Abstract: In various aspects, present disclosure is directed to methods, devices and systems whereby one or more low viscosity fluids may be introduced into a catheter and whereby the one or more low viscosity fluids may be converted into a high viscosity fluid in the catheter, which high viscosity fluid may be delivered from an exit port of the catheter.

Abstract: Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.