Patents by Inventor Joseph M. Beechem

Joseph M. Beechem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20240084361
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: September 21, 2023
    Publication date: March 14, 2024
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG
  • Chemical compositions and methods of using same
    Patent number: 11821026
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: November 21, 2023
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • CHEMICAL COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20230366012
    Abstract: The present disclosure provides compositions and methods for the detection and identification of target nucleic acids within a tissue sample using fluorescent probes, wherein the probes comprise a target-binding domain and a barcode domain.
    Type: Application
    Filed: September 16, 2021
    Publication date: November 16, 2023
    Inventors: Shanshan HE, Dwayne L. DUNAWAY, Isabel LEE, Dae KIM, Joseph M. BEECHEM, Lidan WU
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20230257800
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: March 7, 2023
    Publication date: August 17, 2023
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
    Patent number: 11708602
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: July 25, 2023
    Assignees: NanoString Technologies, Inc., Board of Regents, The University of Texas System
    Inventors: Joseph M. Beechem, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder, Kristina Sorg, Gordon B. Mills
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20230220461
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: December 21, 2022
    Publication date: July 13, 2023
    Inventors: Dwayne DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG, Matthew WALSH, Gavin MEREDITH, Mark MCELWAIN, Peter SKENE, Cassandra Burke
  • CHEMICAL COMPOSITIONS AND METHODS OF USE
    Publication number: 20230183800
    Abstract: The present invention relates to sequencing probes, methods, kits, and apparatuses that provide enzyme-free, amplification-free, and library-free nucleic acid sequencing that has long-read-lengths and with low error rate.
    Type: Application
    Filed: February 22, 2023
    Publication date: June 15, 2023
    Inventors: Joseph M. BEECHEM, Rustem KHAFIZOV
  • CHEMICAL COMPOSITIONS AND METHODS OF USE
    Publication number: 20230160004
    Abstract: The present invention relates to sequencing probes, methods, kits, and apparatuses that provide enzyme-free, amplification-free, and library-free nucleic acid sequencing that has long-read-lengths and with low error rate.
    Type: Application
    Filed: July 29, 2022
    Publication date: May 25, 2023
    Inventors: Joseph M. BEECHEM, Rustem KHAFIZOV
  • Chemical compositions and methods of using same
    Patent number: 11549139
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: May 14, 2019
    Date of Patent: January 10, 2023
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang, Matthew Walsh, Gavin Meredith, Mark McElwain, Peter Skene, Cassandra Burke
  • Chemical compositions and uses thereof
    Patent number: 11473142
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: October 18, 2022
    Assignee: NanoString Technologies, Inc.
    Inventors: Joseph M. Beechem, Dae Kim, Margaret Hoang, Mark Gregory, Erin Piazza, Denise Zhou
  • BIOMOLECULAR PROBES AND METHODS OF DETECTING GENE AND PROTEIN EXPRESSION
    Publication number: 20220220555
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
    Type: Application
    Filed: March 28, 2022
    Publication date: July 14, 2022
    Inventors: Joseph M. BEECHEM, Dae KIM, Margaret HOANG, Mark GREGORY, Erin PIAZZA, Denise ZHOU
  • CHEMICAL COMPOSITIONS AND METHODS OF USING SAME
    Publication number: 20220213532
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Application
    Filed: March 21, 2022
    Publication date: July 7, 2022
    Inventors: Dwayne L. DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG
  • Chemical compositions and uses thereof
    Patent number: 11377689
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: July 5, 2022
    Assignee: NanoString Technologies, Inc.
    Inventors: Joseph M. Beechem, Dae Kim, Margaret Hoang, Mark Gregory, Erin Piazza, Denise Zhou
  • Chemical compositions and methods of using same
    Patent number: 11279969
    Abstract: The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
    Type: Grant
    Filed: September 4, 2019
    Date of Patent: March 22, 2022
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne L. Dunaway, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
  • METHODS, APPARATUSES, SYSTEMS AND DEVICES FOR MOBILE DIGITAL SPATIAL PROFILING OF PATHOLOGICAL SPECIMENS
    Publication number: 20220076809
    Abstract: Embodiments of the present disclosure are directed to a compact, mobile, digital spatial profiling (DSP) system, and associated apparatuses, devices and methods, which are configured to image one or more regions-of-interest (ROIs), and then using UV light to cleave, for example, oligos off antibodies in one or more ROIs (“photocleaving”), and collect the photocleaved oligos for later hybridization and counting.
    Type: Application
    Filed: December 20, 2019
    Publication date: March 10, 2022
    Inventors: Joseph M. BEECHEM, Dwayne DUNAWAY, Jaemyeong JUNG, Peter G. SCHULTZ, Eliot SOSIN, Grant TREMEL
  • CHEMICAL COMPOSITIONS AND USES THEREOF
    Publication number: 20210403998
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
    Type: Application
    Filed: September 16, 2021
    Publication date: December 30, 2021
    Inventors: Joseph M. BEECHEM, Dae KIM, Margaret HOANG, Mark GREGORY, Erin PIAZZA, Denise ZHOU
  • CHEMICAL COMPOSITIONS AND USES THEREOF
    Publication number: 20210403999
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
    Type: Application
    Filed: September 16, 2021
    Publication date: December 30, 2021
    Inventors: Joseph M. BEECHEM, Dae KIM, Margaret HOANG, Mark GREGORY, Erin PIAZZA, Denise ZHOU
  • Methods and apparatuses for gene purification and imaging
    Patent number: 11098301
    Abstract: The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging. A system is provided including a cartridge comprising a sample input area configured to hold a sample, comprising a plurality of hybridized complexes comprising a plurality of target molecules each hybridized with probes and a plurality of non-hybridized probes. The cartridge may also include a first binding chamber configured with first magnetic beads to receive and bind the sample, a first elution channel configured to receive the first magnetic beads and elute the sample from the first magnetic beads, a second binding chamber configured with second magnetic beads to receive and bind the sample, a second elution channel configured to receive the second magnetic beads and elute the sample from the second magnetic beads, and a binding area configured to receive the eluted sample and hold molecules for imaging.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: August 24, 2021
    Assignee: NanoString Technologies, Inc.
    Inventors: Dwayne Dunaway, Rustem Khafizov, Qian Mei, Lucas Dennis, Michael Krouse, Joseph M. Beechem, Isaac Sprague
  • Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
    Patent number: 10640816
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: May 5, 2020
    Assignees: NanoString Technologies, Inc., Board of Regents, The University of Texas System
    Inventors: Joseph M. Beechem, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder, Kristina Sorg, Gordon B. Mills
  • SIMULTANEOUS QUANTIFICATION OF A PLURALITY OF PROTEINS IN A USER-DEFINED REGION OF A CROSS-SECTIONED TISSUE
    Publication number: 20200040382
    Abstract: The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
    Type: Application
    Filed: October 8, 2019
    Publication date: February 6, 2020
    Inventors: Joseph M. BEECHEM, Gordon B. MILLS, Charles WARREN, Chris MERRITT, Jaemyeong JUNG, Dwayne L. DUNAWAY, Scott CROWDER