Abstract: An association between the Ala allele of the P12A variant of the human PPAR? gene and development of CAD, particularly premature CAD, in individuals, and specifically in women, particularly Caucasian women, is described, as are methods of assessing or predicting the likelihood or risk that an individual, such as a woman, will develop premature CAD. Single nucleotide polymorphisms in the human resistin gene, human resistin gene variants, gender-related increase in premature coronary artery disease, methods of assessing or aiding in assessing the risk that an individual will develop premature CAD, and methods of predicting the likelihood or aiding in predicting the likelihood that an individual will develop premature CAD are described.

Abstract: We have identified a 12 kb sequence immediately upstream of the AKT1 gene locus in humans that contains single nucleotide polymorphic polynucleotide (SNPs) whose alleles in strong linkage disequilibrium, and that are prognostic for metabolic syndrome and its metabolic sequellae such as hyperglycemia and type 2 diabetes. The +G205T allele is particularly highly predictive of the potential for protection against metabolic syndrome and its sequellae. The detection of these SNPs by the techniques described herein forms the foundation for methods for genotype-specific clinical interventions designed to slow the rapid population increases in metabolic syndrome and its metabolic sequellae.