Patents by Inventor JOSEPH M. DIRIENZO

JOSEPH M. DIRIENZO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERA COMPRISING BACTERIAL CYTOTOXIN AND METHODS OF USING THE SAME
    Publication number: 20150291667
    Abstract: This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the invention provides methods, utilizing the recombinant polypeptide encoding the chimera, such as a method for inhibiting the proliferation of a neoplastic cell, a method for treating a neoplastic disease in a human subject, a method for inhibiting or suppressing a neoplastic disease in a human subject, and a method for reducing the symptoms associated with a neoplastic disease in a human subject.
    Type: Application
    Filed: November 19, 2014
    Publication date: October 15, 2015
    Inventor: JOSEPH M. DIRIENZO
  • Chimera comprising bacterial cytotoxin and methods of using the same
    Patent number: 8920809
    Abstract: This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the invention provides methods, utilizing the recombinant polypeptide encoding the chimera, such as a method for inhibiting the proliferation of a neoplastic cell, a method for treating a neoplastic disease in a human subject, a method for inhibiting or suppressing a neoplastic disease in a human subject, and a method for reducing the symptoms associated with a neoplastic disease in a human subject.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: December 30, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Joseph M. Dirienzo
  • CHIMERA COMPRISING BACTERIAL CYTOTOXIN AND METHODS OF USING THE SAME
    Publication number: 20120027785
    Abstract: This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the invention provides methods, utilizing the recombinant polypeptide encoding the chimera, such as a method for inhibiting the proliferation of a neoplastic cell, a method for treating a neoplastic disease in a human subject, a method for inhibiting or suppressing a neoplastic disease in a human subject, and a method for reducing the symptoms associated with a neoplastic disease in a human subject.
    Type: Application
    Filed: August 17, 2010
    Publication date: February 2, 2012
    Inventor: JOSEPH M. DIRIENZO