Abstract: The present application provides tricyclic urea compounds that modulate the activity of the V617F variant of JAK2, which are useful in the treatment of various diseases, including cancer.

Abstract: An assembly and a method for manufacturing an assembly for transmitting torque to an aircraft actuator. The assembly and method include a torque tube having a longitudinal axis and an end fitting. The ending fitting includes a connector portion and an engagement portion that is inserted into the torque tube. The engagement portion includes a first end adjacent the connector portion, a second end opposite the first end, and a coupling region between the first and second end that includes an outer coupling surface having an outer diameter and a continuous groove formed thereon. The continuous groove includes two axial grooves that extend along the outer coupling surface along the longitudinal axis and a first parallel groove that extends circumferentially about the longitudinal axis along the outer coupling surface that joins the two axial grooves.

Abstract: A motion detection and imaging method and device 10 for carrying out the method are provided. The device 10 comprises a housing 12 containing a CCD 18 for providing digital image data, a lens 16 for focusing an image on the CCD 18 and a solid state non-volatile memory 24 for storing the digital image data. In one embodiment, the device includes a motion detector 26 for triggering the storage of the digital data.