Patents by Inventor Joseph M. Miano

Joseph M. Miano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Serum Response Factor and Myocardin Control Alzheimer Cerebral Amyloid Angiopathy
    Publication number: 20090214486
    Abstract: Cerebral amyloid angiopathy is involved in Alzheimer dementia through reduction in arterial blood flow that may impair protein synthesis, which is required for learning and memory, and lower the threshold for ischemic injury. Elevated serum response factor (SRF) or myocardin (MYOCD) activity in subjects afflicted by or at risk for development of Alzheimer's disease (AD) promotes a “vascular smooth muscle cell” (VSMC) hypercontractile phenotype in brain arteries and enhance accumulation of A? in the vessel wall. This, in turn, can initiate a disease process in cerebral arteries which can cause brain arterial hypoperfusion and neurovascular uncoupling, that are commonly seen in AD. Thus, SRF and MYOCD represent novel targets for treating arterial dysfunction associated with cognitive decline in AD.
    Type: Application
    Filed: November 14, 2006
    Publication date: August 27, 2009
    Inventors: Berislav V. Zlokovic, Joseph M. Miano
  • Smooth muscle 22.alpha. promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells
    Patent number: 6015711
    Abstract: The present invention relates to isolated DNA molecules encoding the murine SM22.alpha. promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: January 18, 2000
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Eric N. Olson, Li Li, Joseph M. Miano
  • Smooth muscle 22.alpha. promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells
    Patent number: 5837534
    Abstract: The present invention relates to isolated DNA molecules encoding the murine SM22.alpha. promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: November 17, 1998
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Eric N. Olson, Li Li, Joseph M. Miano