Abstract: The present disclosure provides methods of diagnosing a subject as having a pulmonary disease or disorder, e.g., an eosinophilic disease or disorder based on the determination of white blood cell ratios. The disclosure also provides white blood cell ratio-based methods of treating, prognosing, or monitoring a pulmonary disease or disorder, as well as methods of methods of predicting a dosage regimen, identifying a candidate therapeutic agent, identifying a patient as a candidate for a therapeutic agent, and methods of designing a personalized therapy.

Abstract: The present disclosure provides methods of diagnosing a subject as having a pulmonary disease or disorder, e.g., an eosinophilic disease or disorder based on the determination of white blood cell ratios. The disclosure also provides white blood cell ratio-based methods of treating, prognosing, or monitoring a pulmonary disease or disorder, as well as methods of methods of predicting a dosage regimen, identifying a candidate therapeutic agent, identifying a patient as a candidate for a therapeutic agent, and methods of designing a personalized therapy.

Abstract: Embodiments include a collapsible utility pole that snowboarders can carry easily in their pants pocket and can be quickly pulled out and extended to a completely rigid pole to push themselves over flat sections of downhill runs. The utility pole can also being useful when getting off the chair lift to move toward the slopes. Embodiments of the device have the capability of being converted into a small shovel or ice pick by detaching the snow basket and attaching a desired device.