Patents by Inventor Joseph M. Starobin
Joseph M. Starobin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10076259Abstract: A method of determining the susceptibility to ventricular arrhythmias in a subject, the method including determining a reserve of refractoriness (RoR) and a reserve of memory (RoM) and combining the reserve of refractoriness (RoR) and the reserve of memory (RoM) to produce a metric of stability-of-propagation reserve (SoPR) in the subject, a higher value of SoPR indicating lower susceptibility to ventricular arrhythmias in the subject. Systems and apparatus for carrying out the method are also described.Type: GrantFiled: April 21, 2016Date of Patent: September 18, 2018Assignees: University of North Carolina Greensboro, Duke UniversityInventors: Joseph M. Starobin, Vivek Varadarajan, Wanda Krassowska Neu, Salim F. Idriss
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Publication number: 20160287123Abstract: A method of determining the susceptibility to ventricular arrhythmias in a subject, the method including determining a reserve of refractoriness (RoR) and a reserve of memory (RoM) and combining the reserve of refractoriness (RoR) and the reserve of memory (RoM) to produce a metric of stability-of-propagation reserve (SoPR) in the subject, a higher value of SoPR indicating lower susceptibility to ventricular arrhythmias in the subject. Systems and apparatus for carrying out the method are also described.Type: ApplicationFiled: April 21, 2016Publication date: October 6, 2016Inventors: Joseph M. Starobin, Vivek Varadarajan, Wanda Krassowska Neu, Salim F. Idriss
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Patent number: 9144682Abstract: The present invention provides a method of stimulating an excitable tissue (e.g., in vitro, in vivo) with a primary electrical stimulus through a primary electrode at a primary stimulation frequency, to produce a propagating action potential in the excitable tissue. The invention is carried out by concurrently stimulating the excitable tissue with a secondary electrical stimulus through at least one secondary electrode at a secondary stimulation frequency. The primary and secondary stimulation frequencies are preferably different from one another. The secondary electrical stimulus preferably has an amplitude not more than one third that of the primary electrical stimulus. Preferably, propagation of the action potential in the excitable tissue is enhanced (e.g., when propagation of action potentials in the tissue is otherwise unstable, partially blocked, or fully blocked). Apparatus for carrying out the method is also described.Type: GrantFiled: September 3, 2014Date of Patent: September 29, 2015Assignee: The University of North Carolina GreensboroInventors: Joseph M. Starobin, Vivek Varadarajan
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Publication number: 20150057723Abstract: The present invention provides a method of stimulating an excitable tissue (e.g., in vitro, in vivo) with a primary electrical stimulus through a primary electrode at a primary stimulation frequency, to produce a propagating action potential in the excitable tissue. The invention is carried out by concurrently stimulating the excitable tissue with a secondary electrical stimulus through at least one secondary electrode at a secondary stimulation frequency. The primary and secondary stimulation frequencies are preferably different from one another. The secondary electrical stimulus preferably has an amplitude not more than one third that of the primary electrical stimulus. Preferably, propagation of the action potential in the excitable tissue is enhanced (e.g., when propagation of action potentials in the tissue is otherwise unstable, partially blocked, or fully blocked). Apparatus for carrying out the method is also described.Type: ApplicationFiled: September 3, 2014Publication date: February 26, 2015Inventors: Joseph M. Starobin, Vivek Varadarajan
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Patent number: 8855787Abstract: The present invention provides a method of stimulating an excitable tissue (e.g., in vitro, in vivo) with a primary electrical stimulus through a primary electrode at a primary stimulation frequency, to produce a propagating action potential in the excitable tissue. The invention is carried out by concurrently stimulating the excitable tissue with a secondary electrical stimulus through at least one secondary electrode at a secondary stimulation frequency. The primary and secondary stimulation frequencies are preferably different from one another. The secondary electrical stimulus preferably has an amplitude not more than one third that of the primary electrical stimulus. Preferably, propagation of the action potential in the excitable tissue is enhanced (e.g., when propagation of action potentials in the tissue is otherwise unstable, partially blocked, or fully blocked). Apparatus for carrying out the method is also described.Type: GrantFiled: December 1, 2011Date of Patent: October 7, 2014Assignee: The University of North Carolina GreensboroInventors: Joseph M. Starobin, Vivek Varadarajan
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Publication number: 20140243695Abstract: A method of determining the susceptibility to ventricular arrhythmias in a subject, comprises the steps of: (a) collecting (e.g., by surface EKG or intracardiac EKG) at least one QT and DI interval data set from the subject during a stage of gradually increasing heart rate or a stage of gradually decreasing heart rate; (b) determining (e.g.Type: ApplicationFiled: June 28, 2012Publication date: August 28, 2014Applicants: Duke University, University of North Carolina GreensboroInventors: Joseph M. Starobin, Vivek Varadarajan, Wanda Krassowska Neu, Salim F. Idriss
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Publication number: 20130338743Abstract: The present invention provides a method of stimulating an excitable tissue (e.g., in vitro, in vivo) with a primary electrical stimulus through a primary electrode at a primary stimulation frequency, to produce a propagating action potential in the excitable tissue. The invention is carried out by concurrently stimulating the excitable tissue with a secondary electrical stimulus through at least one secondary electrode at a secondary stimulation frequency. The primary and secondary stimulation frequencies are preferably different from one another. The secondary electrical stimulus preferably has an amplitude not more than one third that of the primary electrical stimulus. Preferably, propagation of the action potential in the excitable tissue is enhanced (e.g., when propagation of action potentials in the tissue is otherwise unstable, partially blocked, or fully blocked). Apparatus for carrying out the method is also described.Type: ApplicationFiled: December 1, 2011Publication date: December 19, 2013Applicant: The University of North Carolina GreensboroInventors: Joseph M. Starobin, Vivek Varadarajan
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Patent number: 7123953Abstract: A method of assessing the cardiac arrhythmia risk in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. In one embodiment, the method comprises the steps of: (a) collecting at least one QT and RR interval data set from the subject; (b) separating fluctuations from slow trends in said at least one QT and RR interval data set; (c) comparing said QT and RR fluctuations to one another and (d) generating from the comparison of step (c) partial measures of risk of cardiac arrhythmia in said subject. A greater difference between QT and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject. The data sets are collected in such a manner that they reflect almost exclusively the conduction in the heart muscle and minimize the effect on the data sets of rapid transients due to autonomic nervous system and hormonal control.Type: GrantFiled: December 3, 2002Date of Patent: October 17, 2006Assignee: Mediwave Star Technology Inc.Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Patent number: 7104961Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from said subject during a stage of gradually increasing heart rate up to a predetermined heart rate of at least 130 beats per minute; (b) collecting a second RR-interval data set from said subject during a stage of gradually decreasing heart rate; (c) comparing said first RR-interval data set to said second RR-interval data set to determine the difference between said data sets; and (d) generating from said comparison of step (c) a measure of cardiac ischemia during stimulation in said subject, wherein a greater difference between said first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in said subject.Type: GrantFiled: December 3, 2002Date of Patent: September 12, 2006Assignee: Mediwave Star Technology, Inc.Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Patent number: 6768919Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: GrantFiled: December 26, 2001Date of Patent: July 27, 2004Assignee: Mediwave Star Technology IncInventors: Joseph M. Starobin, Yuri B. Chernyak
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Patent number: 6663572Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first QT- and RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second QT- and RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load); (c) comparing the first QT- and RR-interval data set to the second QT- and RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: GrantFiled: June 26, 2001Date of Patent: December 16, 2003Assignee: MediWave Star Technology Inc.Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Patent number: 6656126Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: GrantFiled: December 26, 2001Date of Patent: December 2, 2003Assignee: MediWave Star Technology, Inc.Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Patent number: 6652467Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: GrantFiled: June 26, 2001Date of Patent: November 25, 2003Assignee: MediWave Star Technology Inc.Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Patent number: 6648829Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: GrantFiled: December 26, 2001Date of Patent: November 18, 2003Assignee: MediWave Star Technology, Inc.Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Patent number: 6648830Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load, or a stage of rest following an abrupt stop of exercise in a patient with coronary artery disease); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: GrantFiled: December 26, 2001Date of Patent: November 18, 2003Assignee: MediWave Star Technology, Inc.Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Publication number: 20030149370Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from said subject during a stage of gradually increasing heart rate up to a predetermined heart rate of at least 130 beats per minute; (b) collecting a second RR-interval data set from said subject during a stage of gradually decreasing heart rate; (c) comparing said first RR-interval data set to said second RR-interval data set to determine the difference between said data sets; and (d) generating from said comparison of step (c) a measure of cardiac ischemia during stimulation in said subject, wherein a greater difference between said first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in said subject.Type: ApplicationFiled: December 3, 2002Publication date: August 7, 2003Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Publication number: 20030130586Abstract: A method of assessing the cardiac arrhythmia risk in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. In one embodiment, the method comprises the steps of: (a) collecting at least one QT and RR interval data set from the subject during (i) a stage of gradually increasing or constant heart rate, (ii) a stage of gradually decreasing or constant heart rate, or (iii) both a stage of gradually increasing or constant heart rate and gradually decreasing or constant heart rate; (b) separating fluctuations from slow trends in said at least one QT and RR interval data set; (c) comparing said QT and RR fluctuations to one another to determine the statistical and functional relationships therebetween; and (d) generating from the comparison of step (c) partial measures of risk of cardiac arrhythmia in said subject. A greater difference between QT and RR fluctuations indicates greater risk of cardiac arrhythmia in said subject.Type: ApplicationFiled: December 3, 2002Publication date: July 10, 2003Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Publication number: 20020165460Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: ApplicationFiled: December 26, 2001Publication date: November 7, 2002Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Publication number: 20020165459Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: ApplicationFiled: December 26, 2001Publication date: November 7, 2002Inventors: Joseph M. Starobin, Yuri B. Chernyak
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Publication number: 20020151806Abstract: A method of assessing cardiac ischemia in a subject to provide a measure of cardiac or cardiovascular health in that subject is described herein. The method comprises the steps of: (a) collecting a first RR-interval data set from the subject during a stage of gradually increasing heart rate (e.g., a stage of gradually increasing exercise load); (b) collecting a second RR-interval data set from the subject during a stage of gradually decreasing heart rate (e.g., a stage of gradually decreasing exercise load, or a stage of rest following an abrupt stop of exercise in a patient with coronary artery disease); (c) comparing the first RR-interval data set to the second RR-interval data set to determine the difference between the data sets; and (d) generating from the comparison of step (c) a measure of cardiac ischemia during exercise in the subject. A greater difference between the first and second data sets indicates greater cardiac ischemia and lesser cardiac or cardiovascular health in the subject.Type: ApplicationFiled: December 26, 2001Publication date: October 17, 2002Inventors: Joseph M. Starobin, Yuri B. Chernyak