Patents by Inventor Joseph M. Timko

Joseph M. Timko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial quinolone compounds
    Patent number: 5385906
    Abstract: A quinolone compound of Formula (I) ##STR1## as defined herein having antibacteria properties, pharmaceutical compositions containing the quinoline compound and method for treating bacterial infections in animals including humans.
    Type: Grant
    Filed: July 20, 1993
    Date of Patent: January 31, 1995
    Assignee: The Upjohn Company
    Inventors: Ronald B. Gammill, Sharon N. Bisaha, Joseph M. Timko, Thomas M. Judge, Michael R. Barbachyn, Kyoung S. Kim
  • Antibacterial quinolone compounds
    Patent number: 5262417
    Abstract: A quinolone compound of Formula (I) ##STR1## as defined herein having antibacteria properties, pharmaceutical compositions containing the quinoline compound and method for treating bacterial infections in animals including humans.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: November 16, 1993
    Assignee: The Upjohn Company
    Inventors: Ronald B. Gammill, Sharon N. Bisaha, Joseph M. Timko, Thomas M. Judge, Michael R. Barbachyn, Kyoung S. Kim
  • Ethynylation of 16-methyl-17-keto steroids
    Patent number: 4618456
    Abstract: The process of the present invention transforms 16.alpha.- or 16.beta.-methyl-17-keto steroids (I) to the corresponding 17.alpha.-ethynyl-17.beta.-hydroxy-16.alpha.- or 16.beta.-methyl steroids (II) without epimerization and loss of stereochemistry of the 16.alpha.- or 16.beta.-methyl group.
    Type: Grant
    Filed: April 26, 1984
    Date of Patent: October 21, 1986
    Assignee: The Upjohn Company
    Inventor: Joseph M. Timko
  • Catalytic process for preparing 3-ester-methyl cephalosporins from desacetyl-7-aminocephalosporanic acid
    Patent number: 4584371
    Abstract: 3-(Activated ester)methyl-3-cephem-4-carboxylic acids are prepared by the direct reaction of a 3-hydroxymethyl-3-cephem-4-carboxylic acid with an activated-O-ester-methyl forming acylating agent in the presence of a 4-(tertiary amino)pyridine catalyst, and an acid absorbing base, in a non-polar liquid solvent at -78.degree. C. to +30.degree. C.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: April 22, 1986
    Assignee: The Upjohn Company
    Inventor: Joseph M. Timko
  • 16.beta.-Methyl steroid process
    Patent number: 4451404
    Abstract: .DELTA..sup.4 -3-keto, .DELTA..sup.1,4 -3-keto and 3.beta.-hydroxy 17-keto steroids (I) are transformed into the corresponding 16-.beta.-methyl-17-keto steroids (IV) by first activating the C-16 position, then methylating. By protecting the C-3 position of the .DELTA..sup.4 -3-keto and 3.beta.-hydroxy steroids the yields are greatly increased.
    Type: Grant
    Filed: February 9, 1983
    Date of Patent: May 29, 1984
    Assignee: The Upjohn Company
    Inventors: Verlan H. Van Rheenen, Joseph M. Timko
  • Introduction of a fluorine atom
    Patent number: 4383947
    Abstract: Perchloryl fluoride when reacted with the appropriately protected 9.alpha.-hydroxyandrostenedione stereoselectively produces the corresponding 6.beta.-fluoro steroid.
    Type: Grant
    Filed: July 24, 1981
    Date of Patent: May 17, 1983
    Assignee: The Upjohn Company
    Inventor: Joseph M. Timko
  • Spironolactone process
    Patent number: 4211701
    Abstract: Spironolactone (VIII) is produced from ethisterone (I) by formation of the lactone (IV), a halo lactone (VI) and a .DELTA.4,6-lactone (VII).
    Type: Grant
    Filed: April 13, 1979
    Date of Patent: July 8, 1980
    Assignee: The Upjohn Company
    Inventor: Joseph M. Timko