Patents by Inventor Joseph MacDougall
Joseph MacDougall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8546369Abstract: The present invention relates to stable salts of creatine imino sugar amides and an inorganic or organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral and parenteral administration. Methods of preparation and use of these compositions are also provided.Type: GrantFiled: August 28, 2008Date of Patent: October 1, 2013Assignee: Northern Innovations Holding Corp.Inventors: Marvin Heuer, Michele Molino, Joseph MacDougall
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Patent number: 8426395Abstract: Compounds produced by combining imino sugars and creatine are herein disclosed. The compounds being in the form of a creatine imino sugar amides and produced by the disclosed methods; protecting the guanidine group of creatine and then activating the protected creatine with DCC and reacting it with an imino sugar, followed by removal of the guanidine protecting groups. The resulting creatine imino sugar amides have enhanced stability in solution as compared to related esters. In addition, specific benefits are conferred by the imino sugar in addition to, and separate from, the creatine substituent. Methods of preparation and use of these compounds are also disclosed.Type: GrantFiled: August 28, 2008Date of Patent: April 23, 2013Assignee: Northern Northern Innovations Holding CorpInventors: Marvin A. Heuer, Michele Molino, Joseph MacDougall
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Patent number: 8236952Abstract: The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide linkage and produced by one of two disclosed methods; 1) reacting orotic acid or derivatives thereof with a thionyl halide, and then combining the acyl halide with an amino acid in the presence of dichloromethane and a DMAP catalyst; or 2) protecting the carboxylic acid of an amino acid and then combining the amino acid with a DCC activated orotic acid, followed by removal of the carboxylic acid protecting group. The resulting amino acid orotate amide has an enhanced stability in solution as compared to a related ester. In addition, specific benefits are conferred by the particular amino acid used to form the compounds in addition to, and separate from, the orotate substituent.Type: GrantFiled: December 18, 2007Date of Patent: August 7, 2012Assignee: Northern Innovations Holding Corp.Inventors: Joseph MacDougall, Shan Chaudhuri
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Publication number: 20110189312Abstract: Compositions and methods for promoting or maintaining protein accretion in cells, particularly in skeletal muscle cells, by supporting heat shock protein function. The compositions comprise glutamine and additional components directed at enhancing the activity of heat shock proteins.Type: ApplicationFiled: February 2, 2011Publication date: August 4, 2011Inventors: Marvin A. Heuer, Ken Clement, Michele Molino, Joseph Macdougall, Phillip Apong, Jason Peters
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Patent number: 7956218Abstract: The present invention relates to stable salts of ?-alanine and an organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.Type: GrantFiled: December 12, 2007Date of Patent: June 7, 2011Assignee: Northern Innovations and Formulations Corp.Inventors: Michele Molino, Joseph MacDougall
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Patent number: 7956090Abstract: A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one ?-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.Type: GrantFiled: July 8, 2009Date of Patent: June 7, 2011Inventors: Michele Molino, Joseph MacDougall
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Patent number: 7714154Abstract: The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.Type: GrantFiled: April 8, 2008Date of Patent: May 11, 2010Assignee: Northern Innovations and Formulations Corp.Inventor: Joseph MacDougall
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Patent number: 7645794Abstract: A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one ?-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.Type: GrantFiled: September 11, 2007Date of Patent: January 12, 2010Assignee: Multi Formulations Ltd.Inventors: Michele Molino, Joseph MacDougall
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Publication number: 20090270501Abstract: A nutritional supplement comprising at least a therapeutically effective amount of ethyl pyruvate and a therapeutically effective amount of at least one ?-hydroxy branched-chain amino acid metabolite is provided by the present invention. The ingredients of the present nutritional supplement substantially simultaneously act to induce a anabolically-favorable state for muscle by substantially simultaneously maintaining blood and muscle physiological pH levels as well as increasing cellular concentrations of branched-chain amino acids. Both a composition and a method are provided by the present disclosure.Type: ApplicationFiled: July 8, 2009Publication date: October 29, 2009Inventors: Michele Molino, Joseph MacDougall
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Publication number: 20090263519Abstract: A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and/or paeoniflorin or derivative of paeoniflorin and an effective amount of Schisandrin B, wherein the ingredients act substantially simultaneously, via differing mechanism, to enhance the expression of heat shock protein in cells, particularly heat shock protein 72 in skeletal muscle. A method of same is also provided.Type: ApplicationFiled: June 29, 2009Publication date: October 22, 2009Inventors: Michele Molino, Joseph MacDougall, Phil Apong
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Publication number: 20090196940Abstract: Compositions and methods for promoting or maintaining protein accretion in cells, particularly in skeletal muscle cells, by supporting heat shock protein function. The compositions comprise glutamine and additional components directed at enhancing the activity of heat shock proteins.Type: ApplicationFiled: December 18, 2008Publication date: August 6, 2009Inventors: Marvin A. Heuer, Ken Clement, Michele Molino, Joseph MacDougall, Philip Apong, Jason Peters
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Publication number: 20090162458Abstract: A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and/or paeoniflorin or derivative of paeoniflorin and an effective amount of Schisandrin B, wherein the ingredients act substantially simultaneously, via differing mechanism, to enhance the expression of heat shock protein in cells, particularly heat shock protein 72 in skeletal muscle. A method of same is also provided.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Applicant: H3 FORMULATIONS LTD.Inventors: Michele Molino, Joseph MacDougall, Phil Apong
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Publication number: 20090163573Abstract: A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and an effective amount of glutamine or derivative of glutamine, wherein the ingredients act substantially simultaneously to increase protein synthesis and inhibit protein degradation in skeletal muscle, via enhanced expression of heat shock proteins in cells, particularly heat shock protein 72. A method of same is also provided.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Applicant: MULTI FORMULATIONS LTD.Inventors: Marvin A. Heuer, Ken Clement, Michele Molino, Joseph MacDougall
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Publication number: 20090156676Abstract: The present invention relates to stable salts of ?-alanine and an organic acid endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.Type: ApplicationFiled: December 12, 2007Publication date: June 18, 2009Applicant: IOVATE T. & P. INC.Inventors: Michele Molino, Joseph MacDougall
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Publication number: 20090156648Abstract: The present invention relates to stable salts of pyridoxine and ?-hydroxyisocaproic acid (HICA) endowed with enhanced nutritional and/or therapeutical efficacy in respect to their individual effects and to solid compositions containing such salts, particularly suited to oral administration. A method of preparation is also provided.Type: ApplicationFiled: December 12, 2007Publication date: June 18, 2009Applicant: IOVATE T. & P. INC.Inventors: Michele Molino, Joseph MacDougall
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Publication number: 20090156812Abstract: The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide linkage and produced by one of two disclosed methods; 1) reacting orotic acid or derivatives thereof with a thionyl halide, and then combining the acyl halide with an amino acid in the presence of dichloromethane and a DMAP catalyst; or 2) protecting the carboxylic acid of an amino acid and then combining the amino acid with a DCC activated orotic acid, followed by removal of the carboxylic acid protecting group. The resulting amino acid orotate amide has an enhanced stability in solution as compared to a related ester. In addition, specific benefits are conferred by the particular amino acid used to form the compounds in addition to, and separate from, the orotate substituent.Type: ApplicationFiled: December 18, 2007Publication date: June 18, 2009Applicant: IOVATE T. & P. INC.Inventors: Joseph MacDougall, Shan Chaudhuri
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Publication number: 20090156647Abstract: A nutritional supplement comprising at least a therapeutically effective amount of pyridoxine ?-hydroxyisocaproate is provided by the present invention. The ingredients of the present nutritional supplement act substantially simultaneously to maintain physiological blood and muscular pH and increase the time to muscular fatigue in a mammal during periods of repetitive forceful muscular exercise. A method of use is provided by the present disclosure.Type: ApplicationFiled: December 12, 2007Publication date: June 18, 2009Applicant: IOVATE T. & P. INC.Inventors: Michele Molino, Joseph MacDougall
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Publication number: 20090156634Abstract: A nutritional composition comprising at least an effective amount of trigonelline or derivative of trigonelline and an effective amount of tropane alkaloids, wherein the ingredients act substantially simultaneously improve the consistency of muscular contractions with respect to applied force and relaxation cycles over time and reduce the onset of central fatigue. A method of same is also provided.Type: ApplicationFiled: December 12, 2007Publication date: June 18, 2009Applicant: Iovate T. & P. Inc.Inventors: Michele Molino, Joseph MacDougall
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Patent number: 7511162Abstract: The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.Type: GrantFiled: May 10, 2007Date of Patent: March 31, 2009Assignee: Multi Formulations Ltd.Inventor: Joseph MacDougall
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Patent number: 7511164Abstract: The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.Type: GrantFiled: September 17, 2007Date of Patent: March 31, 2009Assignee: Multi Formulations LtdInventors: Shan Chaudhuri, Joseph MacDougall, Jason Peters, James Ramsbottom