Abstract: The present invention relates to compounds that modify low density lipoprotein receptor (LDLR) expression. The compounds have the structural formula I shown below: wherein m, R1, n, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with elevated levels of low density lipoprotein cholesterol (LDL-C).

Abstract: Tissue compression devices having pressure indicators and methods of using the same. The tissue compression devices provide feedback to a user with respect to the pressure being applied to selected tissue at a selected location such as a radial artery to assist the user in applying the desired amount of pressure to the tissue (such as the pressure needed to achieve hemostasis at an access site). The pressure indication may be provided by a ring indicator that moves between two configurations (e.g., a concave configuration and a convex configuration), a bellow chamber in a housing, a bladder located below a bladder window, etc.

Abstract: Tissue compression devices having pressure indicators and methods of using the same. The tissue compression devices provide feedback to a user with respect to the pressure being applied to selected tissue at a selected location such as a radial artery to assist the user in applying the desired amount of pressure to the tissue (such as the pressure needed to achieve hemostasis at an access site). The pressure indication may be provided by a ring indicator that moves between two configurations (e.g., a concave configuration and a convex configuration), a bellow chamber in a housing, a bladder located below a bladder window, etc.

Abstract: Tissue compression devices with deflecting pressure elements and methods of using the same are described herein. The tissue compression devices include a pressure element and a retention structure attached to the pressure element. The retention structure may be configured to retain the intermediate portion of the pressure element over selected tissue in a selected location on a patient (such as, e.g., over a radial artery access site). Movement of first and second end portions of the pressure element towards each other along an actuation axis causes the intermediate portion of the pressure element to deflect away from the actuation axis towards the selected tissue.

Abstract: Tissue compression devices with a combination of fixation and tension straps and methods of using the same are described herein. The tissue compression devices include a combination of fixation and tension straps that are used together to fix or attach the tissue compression device over selected tissue at a selected location on a patient and to apply pressure to the selected tissue. In one or more embodiments, the fixation straps are sued to fix or attach the tissue compression device and the tension straps are used to provide tension that is converted to pressure on the selected tissue.

Abstract: A pharmaceutical delivery apparatus with an automatic syringe retraction following a manually controlled injection. The apparatus includes a housing (28), a syringe carriage (90), a medication-filled syringe (70) held within the carriage, the syringe needle tip being disposed within the housing in a first position and projecting from the housing beyond the housing proximal end for insertion into an injection site in a second position, a manually shiftable plunger (130), means on the carriage and the housing and the plunger for causing the carriage to advance from the first position to the second position and for injecting medicine from the syringe when the plunger is manually plunged proximally toward the housing, and means on the carriage and the plunger for causing the carriage to retract from the second position to a position at which the needle tip is disposed within the housing when the plunger shifts distally.

Abstract: Tissue compression devices including a multi-chamber bladder that is retained within the tissue compression device, with the multi-chamber bladder being positioned in a bladder orifice in a base of a compression device body. The multi-chamber bladder includes at least one upper chamber located above the base and at least one lower chamber located below the base. The lower chamber is located between the base and a selected location on a patient when the compression device is positioned over selected tissue such as, e.g., a radial artery, as described herein.

Abstract: Tissue compression devices having pressure indicators and methods of using the same. The tissue compression devices provide feedback to a user with respect to the pressure being applied to selected tissue at a selected location such as a radial artery to assist the user in applying the desired amount of pressure to the tissue (such as the pressure needed to achieve hemostasis at an access site). The pressure indication may be provided by a ring indicator that moves between two configurations (e.g., a concave configuration and a convex configuration), a bellow chamber in a housing, a bladder located below a bladder window, etc.

Abstract: Tissue compression devices having a tension limiting strap retainer and methods of using the same. The tissue compression devices described herein may include a strap retainer that is attached to a base by an elastic member that is configured to draw the strap retainer towards the base. The tissue compression devices described herein may also include a tension indicator that extends between the base of the tissue compression device and strap retainer. The tension indicator may be configured to limit the travel distance of the strap retainer away from the base in response to forces acting on the strap retainer. The tension indicator may also provide visual feedback to a user of the tension force in a strap to attach the tissue compression device to a patient.

Abstract: A delay mechanism for staging the operation of an automatic injection apparatus (20) to ensure medication contents are properly delivered prior to the needled syringe (32) of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (50), a follower (110), a locking member, a damping compound, and a driver and a driver biasing element (44). The shuttle is for a needled syringe of the apparatus and includes a first latching element. The follower includes a second latching element and a cammable surface, which second latching element is for cooperating with the first latching element to limit motion of the shuttle relative to the follower in a second direction opposite the first direction.

Abstract: A pharmaceutical delivery apparatus with an automatic syringe retraction following a manually controlled injection. The apparatus includes a housing (28), a syringe carriage (90), a medication-filled syringe (70) held within the carriage, the syringe needle tip being disposed within the housing in a first position and projecting from the housing beyond the housing proximal end for insertion into an injection site in a second position, a manually shiftable plunger (130), means on the carriage and the housing and the plunger for causing the carriage to advance from the first position to the second position and for injecting medicine from the syringe when the plunger is manually plunged proximally toward the housing, and means on the carriage and the plunger for causing the carriage to retract from the second position to a position at which the needle tip is disposed within the housing when the plunger shifts distally.

Abstract: A conferencing assembly for use with at least one computer, the assembly including a table top forming a table top opening, a leg support structure, a display screen supported adjacent the top surface, a switcher for controlling input to the display screen, a plurality of handsets, each hand set including a selector button usable to send a signal to the switcher thereby causing the switcher to link a computer associated with the selector button to the display, a plurality of handset cables, each handset cable having first and second ends linked to the switcher and an associated selector button, respectively, for passing signals from the selector buttons to the switcher, a take up assembly including a separate weight for each of the handset cables, the take up assembly disposed below the top member and aligned with the top opening, each handset cable linked to an associated weight, each weight applying a force tending to pull the second end of the associated handset cable into the opening.

Abstract: A delay mechanism for staging the operation of an automatic injection apparatus (20) to ensure medication contents are properly delivered prior to the needled syringe (32) of the apparatus being retracted. In one form, the delay mechanism includes a shuttle (50), a follower (110), a locking member, a damping compound, and a driver and a driver biasing element (44). The shuttle is for a needled syringe of the apparatus and includes a first latching element. The follower includes a second latching element and a cammable surface, which second latching element is for cooperating with the first latching element to limit motion of the shuttle relative to the follower in a second direction opposite the first direction.

Abstract: A conferencing assembly for use with at least one computer, the assembly including a table top forming a table top opening, a leg support structure, a display screen supported adjacent the top surface, a switcher for controlling input to the display screen, a plurality of handsets, each hand set including a selector button usable to send a signal to the switcher thereby causing the switcher to link a computer associated with the selector button to the display, a plurality of handset cables, each handset cable having first and second ends linked to the switcher and an associated selector button, respectively, for passing signals from the selector buttons to the switcher, a take up assembly including a separate weight for each of the handset cables, the take up assembly disposed below the top member and aligned with the top opening, each handset cable linked to an associated weight, each weight applying a force tending to pull the second end of the associated handset cable into the opening.

Abstract: A flexible sign board for blade signs is provided. The sign board has a frame with a mounting bracket that is connected to a resilient support. The resilient support is a plurality of springs connected to a shelf or the wall bracket according to the desired application. The springs support and maintain the sign frame perpendicular to the wall or shelf the sign is attached to and thereby provides a "swing away" effect of the sign when bumped into or pushed out of the consumers way. The flexible sign frame and mounting thereof will not obstruct the consumer aisle, and thereby enables the increased visibility of the displayed items from a further distance. The flexible sign board system provides the ability to adapt the sign board to an infinite variety of varying shelf depths without using or taking away valuable retail shelf space.

Abstract: A flexible sign board for blade signs is provided. The sign board has a frame with a mounting bracket that is connected to a resilient support. The resilient support is a plurality of springs connected to a shelf or the wall bracket according to the desired application. The springs support and maintain the sign frame perpendicular to the wall or shelf it the sign is attached to and thereby provides a "swing away" effect of the sign when bumped into or pushed out of the consumers way. The flexible sign frame and mounting thereof will not obstruct the consumer aisle, and thereby enables the increased visibility of the displayed items from a further distance. The Flexible sign board system provides the ability to adapt the sign board to an infinite variety of varying shelf depths without using or taking away valuable retail shelf space.

Abstract: A display rack for dispensing packaged items from a vertical stack of items contained within magazines which are interchangeably received and retained by columns within a housing. The leading item within each magazine may be withdrawn through the discharge opening of the housing and upon withdrawal, a next leading item will be placed in a position for withdrawal as a result of the positive gravity feed of the magazine. A guard is provided which covers the discharge opening of the housing thereby preventing access to the packaged items within the magazines. The display rack also includes a means for locking the guard in first and second positions.