Patents by Inventor Joseph Matthew WATTS

Joseph Matthew WATTS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for RNA-encoded DNA-replacement of alleles
    Patent number: 11926834
    Abstract: This invention relates to recombinant nucleic constructs comprising Type V CRISPR-Cas effector proteins, reverse transcriptases and extended guide nucleic acids and methods of use thereof for modifying nucleic acids in plants.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: March 12, 2024
    Assignee: Pairwise Plants Services, Inc.
    Inventors: Joseph Matthew Watts, Aaron Hummel, Yongjoo Kim, Shai Joshua Lawit, David Schwark
  • VARIANTS OF CAS12A NUCLEASES AND METHODS OF MAKING AND USE THEREOF
    Publication number: 20240076639
    Abstract: This invention relates to variants of Cas12a nucleases having altered protospacer adjacent motif recognition specificity. The invention further relates to methods of making CRISPR-CAS nuclease variants and methods of modifying nucleic acids using the variants.
    Type: Application
    Filed: November 6, 2023
    Publication date: March 7, 2024
    Inventor: Joseph Matthew Watts
  • Variants of CAS12A nucleases and methods of making and use thereof
    Patent number: 11866745
    Abstract: This invention relates to variants of Cas12a nucleases having altered protospacer adjacent motif recognition specificity. The invention further relates to methods of making CRISPR-CAS nuclease variants and methods of modifying nucleic acids using the variants.
    Type: Grant
    Filed: October 15, 2020
    Date of Patent: January 9, 2024
    Assignee: Pairwise Plants Services, Inc.
    Inventor: Joseph Matthew Watts
  • OPTIMIZED PROTEIN LINKERS AND METHODS OF USE
    Publication number: 20240002821
    Abstract: The invention relates to peptide linkers and fusion proteins comprising linkers designed for optimizing the activity of the proteins comprised therein, and methods for using the same. The invention further relates to newly designed Cas12a-based adenine base editors.
    Type: Application
    Filed: June 14, 2023
    Publication date: January 4, 2024
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • ENGINEERED PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20230383271
    Abstract: Described herein are engineered proteins and methods of use of such proteins. Also described herein are complexes, compositions, and systems including engineered proteins of the present invention, each of which may be used for modifying and/or editing a target nucleic acid. An engineered protein of the present invention may be an enzyme and/or may be an RNA-guided DNA-binding protein.
    Type: Application
    Filed: February 28, 2023
    Publication date: November 30, 2023
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • SUPPRESSION OF SHADE AVOIDANCE RESPONSE IN PLANTS
    Publication number: 20230284577
    Abstract: This invention relates to compositions and methods for modifying an endogenous nucleic acid encoding a Phytochrome A (PHYA) polypeptide for suppression of the shade avoidance response in plants. The invention further relates to plants produced using the methods and compositions of the invention.
    Type: Application
    Filed: January 30, 2023
    Publication date: September 14, 2023
    Inventors: Julius Mojica, Joseph Matthew Watts, Molian Deng, Thomas Louis Slewinski
  • Optimized protein linkers and methods of use
    Patent number: 11718838
    Abstract: The invention relates to peptide linkers and fusion proteins comprising linkers designed for optimizing the activity of the proteins comprised therein, and methods for using the same. The invention further relates to newly designed Cas12a-based adenine base editors.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: August 8, 2023
    Assignee: Pairwise Plants Services. Inc.
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • Optimized protein linkers and methods of use
    Patent number: 11708568
    Abstract: The invention relates to peptide linkers and fusion proteins comprising linkers designed for optimizing the activity of the proteins comprised therein, and methods for using the same. The invention further relates to newly designed Cas12a-based cytosine base editors.
    Type: Grant
    Filed: June 22, 2021
    Date of Patent: July 25, 2023
    Assignee: Pairwise Plants Services, Inc.
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • OPTIMIZED CRISPR-CAS NUCLEASES AND BASE EDITORS AND METHODS OF USE THEREOF
    Publication number: 20230183726
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Application
    Filed: February 6, 2023
    Publication date: June 15, 2023
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • OPTIMIZED CRISPR-CAS NUCLEASES AND BASE EDITORS AND METHODS OF USE THEREOF
    Publication number: 20230114342
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Application
    Filed: October 20, 2022
    Publication date: April 13, 2023
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • Optimized CRISPR-Cas nucleases and base editors and methods of use thereof
    Patent number: 11591607
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: February 28, 2023
    Assignee: Pairwise Plants Services, Inc.
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • COMPOSITIONS AND METHODS FOR RNA-ENCODED DNA-REPLACEMENT OF ALLELES
    Publication number: 20220145334
    Abstract: This invention relates to recombinant nucleic constructs comprising CRISPR-Cas effector proteins, reverse transcriptases and extended guide nucleic acids and methods of use thereof for modifying nucleic acids in plants.
    Type: Application
    Filed: November 5, 2021
    Publication date: May 12, 2022
    Inventors: Yongjoo Kim, Joseph Matthew Watts, Aaron Hummel, Shai Joshua Lawit, David Schwark
  • ENGINEERED PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20220112473
    Abstract: Described herein are engineered proteins and methods of use of such proteins. Also described herein are complexes, compositions, and systems including engineered proteins of the present invention, each of which may be used for modifying or editing a target nucleic acid. An engineered protein of the present invention may be an enzyme and/or may be an RNA-guided DNA-binding protein.
    Type: Application
    Filed: August 27, 2021
    Publication date: April 14, 2022
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • OPTIMIZED PROTEIN LINKERS AND METHODS OF USE
    Publication number: 20220025346
    Abstract: The invention relates to peptide linkers and fusion proteins comprising linkers designed for optimizing the activity of the proteins comprised therein, and methods for using the same. The invention further relates to newly designed Cas12a-based adenine base editors.
    Type: Application
    Filed: July 21, 2021
    Publication date: January 27, 2022
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • OPTIMIZED PROTEIN LINKERS AND METHODS OF USE
    Publication number: 20210355466
    Abstract: The invention relates to peptide linkers and fusion proteins comprising linkers designed for optimizing the activity of the proteins comprised therein, and methods for using the same. The invention further relates to newly designed Cas12a-based cytosine base editors.
    Type: Application
    Filed: June 22, 2021
    Publication date: November 18, 2021
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • Optimized protein linkers and methods of use
    Patent number: 11072785
    Abstract: The invention relates to peptide linkers and fusion proteins comprising linkers designed for optimizing the activity of the proteins comprised therein, and methods for using the same. The invention further relates to newly designed Cas12a-based cytosine base editors.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: July 27, 2021
    Assignee: PAIRWISE PLANTS SERVICES, INC.
    Inventors: Sharon Leigh Guffy, Joseph Matthew Watts
  • COMPOSITIONS AND METHODS FOR RNA-TEMPLATED EDITING IN PLANTS
    Publication number: 20210147862
    Abstract: This invention relates to recombinant nucleic constructs comprising a DNA binding domain, an endonuclease and a reverse transcriptase and methods of use thereof for modifying nucleic acids in plants.
    Type: Application
    Filed: October 23, 2020
    Publication date: May 20, 2021
    Inventors: Aaron Hummel, Joseph Matthew Watts, Shai Joshua Lawit, Nathaniel Graham, Larry Gilbertson, Ervin Nagy, Linda Rymarquis
  • OPTIMIZED CRISPR-CAS NUCLEASES AND BASE EDITORS AND METHODS OF USE THEREOF
    Publication number: 20210147861
    Abstract: This invention relates to CRISPR-Cas nucleases codon optimized for expression in plants and nucleic acid constructs encoding base editors comprising a CRISPR-Cas nuclease and a deaminase domain, wherein the nucleic acid constructs are optimized for expression in a plant. The invention further relates to methods of modifying nucleic acids using the nucleic acid constructs.
    Type: Application
    Filed: October 23, 2020
    Publication date: May 20, 2021
    Inventors: Nathaniel Graham, Aaron Hummel, Yongjoo Kim, Joseph Matthew Watts
  • COMPOSITIONS AND METHODS FOR RNA-ENCODED DNA-REPLACEMENT OF ALLELES
    Publication number: 20210130835
    Abstract: This invention relates to recombinant nucleic constructs comprising Type V CRISPR-Cas effector proteins, reverse transcriptases and extended guide nucleic acids and methods of use thereof for modifying nucleic acids in plants.
    Type: Application
    Filed: November 5, 2020
    Publication date: May 6, 2021
    Inventors: Joseph Matthew Watts, Aaron Hummel, Yongjoo Kim, Shai Joshua Lawit, David Schwark
  • VARIANTS OF CAS12A NUCLEASES AND METHODS OF MAKING AND USE THEREOF
    Publication number: 20210115421
    Abstract: This invention relates to variants of Cas12a nucleases having altered protospacer adjacent motif recognition specificity. The invention further relates to methods of making CRISPR-CAS nuclease variants and methods of modifying nucleic acids using the variants.
    Type: Application
    Filed: October 15, 2020
    Publication date: April 22, 2021
    Inventors: Joseph Matthew Watts, Sathya Sheela Jali