Patents by Inventor Joseph McNamara
Joseph McNamara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11114183Abstract: In one embodiment, a method for identifying and forming a simulant includes identifying a composition, identifying a plurality of ingredients, the simulant being a combination of the ingredients, identifying for evaluation one or more metrics of the simulant, determining proportions of each of the ingredients by optimizing a quadratic function based on the one or more metrics of the simulant, rendering, via a GUI, a 3D plot that depicts the metrics and a target point specified by the target values of the composition, when the target point is contained within a convex set defined by the identified ingredients, outputting the determined proportions of each of the identified ingredients and, otherwise, receiving user input to adjust the convex set by user selecting and moving the data points of the 3D plot to modify the metrics of the simulant to produce a new 3D plot, and identifying alternative ingredients and/or alternative proportions.Type: GrantFiled: March 22, 2021Date of Patent: September 7, 2021Assignee: The Government of the United States of America, as represented by the Secretary of Homeland SecurityInventors: Joseph McNamara, Alexander DeMasi, Michael Brogden, Ronald Krauss
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Publication number: 20210210172Abstract: In one embodiment, a method for identifying and forming a simulant includes identifying a composition, identifying a plurality of ingredients, the simulant being a combination of the ingredients, identifying for evaluation one or more metrics of the simulant, determining proportions of each of the ingredients by optimizing a quadratic function based on the one or more metrics of the simulant, rendering, via a GUI, a 3D plot that depicts the metrics and a target point specified by the target values of the composition, when the target point is contained within a convex set defined by the identified ingredients, outputting the determined proportions of each of the identified ingredients and, otherwise, receiving user input to adjust the convex set by user selecting and moving the data points of the 3D plot to modify the metrics of the simulant to produce a new 3D plot, and identifying alternative ingredients and/or alternative proportions.Type: ApplicationFiled: March 22, 2021Publication date: July 8, 2021Applicant: The Government of the United States of America, as represented by the Secretary of Homeland SecurityInventors: Joseph McNamara, Alexander DeMasi, Michael Brogden, Ronald Krauss
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Patent number: 10998087Abstract: Systems and methods are provided for forming a simulant. In accordance with one embodiment, a method is provided for identifying and forming a simulant. The method identifies, using processing circuitry, a compound. The method further identifies, using the processing circuitry, a plurality of ingredients, wherein the simulant is a combination of the plurality of ingredients. The method further identifies for evaluation, using the processing circuitry, one or more metrics of the simulant. The method further determines, using the processing circuitry, proportions of each of the plurality of ingredients by optimizing a quadratic function based on the one or more metrics of the simulant. The method further outputs the proportions of each of the plurality of ingredients, and forms a mixture of the plurality of ingredients based on the proportions of each of the plurality of ingredients.Type: GrantFiled: August 25, 2016Date of Patent: May 4, 2021Assignee: The Government of the United States of Amercia as represented by the Secretary of Homeland SecurityInventors: Joseph McNamara, Alexander DeMasi, Michael Brogden, Ronald Krauss
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Publication number: 20190195988Abstract: Various embodiments of the present invention are directed towards a simulant and method relating to producing a simulant. For example, a simulant of a target threat includes at least one component ingredient characterized by a corresponding component loss factor that is essentially zero. The simulant is configured to exhibit a simulant dielectric constant corresponding to a simulant reflectivity substantially equivalent to a threat reflectivity. A method of producing a simulant of a target threat includes generating an ellipse-like curved solution space corresponding to a plurality of candidate threat reflectivities, identifying a threat dielectric constant, from among respective threat dielectric constants of the candidate threat reflectivities forming the curved solution space, and identifying at least one weight proportion of at least one corresponding simulant ingredient.Type: ApplicationFiled: December 21, 2018Publication date: June 27, 2019Applicant: The Government of the United States of America, as represented by the Secretary of Homeland SecurityInventors: Ronald Krauss, Michael Brogden, Joseph McNamara
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Publication number: 20180060450Abstract: Systems and methods are provided for forming a simulant. In accordance with one embodiment, a method is provided for identifying and forming a simulant. The method identifies, using processing circuitry, a compound. The method further identifies, using the processing circuitry, a plurality of ingredients, wherein the simulant is a combination of the plurality of ingredients. The method further identifies for evaluation, using the processing circuitry, one or more metrics of the simulant. The method further determines, using the processing circuitry, proportions of each of the plurality of ingredients by optimizing a quadratic function based on the one or more metrics of the simulant. The method further outputs the proportions of each of the plurality of ingredients, and forms a mixture of the plurality of ingredients based on the proportions of each of the plurality of ingredients.Type: ApplicationFiled: August 25, 2016Publication date: March 1, 2018Applicant: The Government of the United States of America, as represented by the Secretary of Homeland SecurityInventors: Joseph McNamara, Alexander DeMasi, Michael Brogden, Ronald Krauss
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Patent number: 8420646Abstract: The present invention is directed to tricyclic tetrahydroquinoline compounds of formula I, and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R5, R20 and X are as described herein and to pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: GrantFiled: December 20, 2010Date of Patent: April 16, 2013Assignee: PAH P&U LLCInventors: Michael Robert Barbachyn, Paul Joseph Dobrowolski, Alexander Ross Hurd, Dennis Joseph McNamara, John Raymond Palmer, Arthur Glenn Romero, J. Craig Ruble, Debra Ann Sherry, Lisa Marie Thomasco, Peter Laurence Toogood
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Publication number: 20110092494Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: ApplicationFiled: December 20, 2010Publication date: April 21, 2011Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
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Patent number: 7786131Abstract: The present invention relates to pyrimido [5,4-d] pyrimidine compounds of Formula II or a pharmaceutically acceptable salt thereof, wherein Q is and X, E1, E2, E3, R6 and p are as defined herein. The compounds of this invention are irreversible inhibitors of tyrosine kinases and are useful in the treatment of cancer, atherosclerosis, restenosis, endometriosis and psoriasis.Type: GrantFiled: May 20, 2003Date of Patent: August 31, 2010Assignee: Warner-Lambert CompanyInventors: Alexander James Bridges, William Alexander Denny, Ellen Myra Dobrusin, Annette Marian Doherty, David William Fry, Dennis Joseph McNamara, Howard Daniel Hollis Showalter, Jeffrey B. Smaill, Hairong Zhou
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Publication number: 20100022524Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: ApplicationFiled: August 28, 2009Publication date: January 28, 2010Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
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Patent number: 7605157Abstract: The invention includes tetrahydroquinoline and related compounds of formula I and pharmaceutical compositions thereof, that exhibit useful antibacterial activity again a wide range of human and veterinary pathogensType: GrantFiled: March 7, 2007Date of Patent: October 20, 2009Assignee: Pharmacia & Upjohn Company LLCInventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
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Patent number: 7208490Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogensType: GrantFiled: October 2, 2003Date of Patent: April 24, 2007Assignee: Pharmacia & Upjohn Company LLCInventors: Michael Robert Barbachyn, Gordan L. Bundy, Paul Joseph Dobrowolski, Alexander Ross Hurd, Gary E. Martin, Dennis Joseph McNamara, John Raymond Palmer, Donna L. Romero, Arthur Glenn Romero, J. Craig Ruble, Debra Ann Sherry, Lisa Marie Thomasco, Peter Laurence Toogood
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Patent number: 7169778Abstract: Disclosed are compounds of Formulae (Ia), (Ib), (Ic), (Id) wherein: W is NH, S, SO, or SO2; R2 is (un)substituted aryl, (un)substituted heteroaryl, or (un)substituted carbocycle or heterocycle; Q is hydrogen or lower alkyl; R4 and R6 are the same or different and represent hydrogen, halogen, lower alkyl, lower alkoxy, (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl; and R8 is hydrogen, lower alkyl or an (un)substituted carbocyclic group containing from 3–7 members, up to two of which members are optionally hetero atoms selected from oxygen and nitrogen; or R8 is (un)substituted aryl, (un)substituted heteroaryl, (un)substituted arylalkyl or (un)substituted heteroarylalkyl. These compounds are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cyclin-dependent kinases (cdks) and growth factor-mediated kinases.Type: GrantFiled: June 21, 2000Date of Patent: January 30, 2007Assignee: Warner-Lambert CompanyInventors: William Alexander Denny, Gordon William Rewcastle, Ellen Dobrusin, James Bernard Kramer, Dennis Joseph McNamara, Howard Daniel Hollis Showalter, Peter Laurence Toogood
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Patent number: 6862437Abstract: A dual band RF tuning circuit (1) has a first impedance element (4) and a second impedance element (5) between an RF input port (2) and an RF output port (3), tuning being provided by the impedance elements (4, 5) to a first RF signal, and a switching transistor (9) connected to the second impedance element (5) to open circuit the second impedance element (5) for tuning to a second RF signal by the first impedance element (4) alone.Type: GrantFiled: November 29, 1999Date of Patent: March 1, 2005Assignee: Tyco Electronics CorporationInventor: Brian Joseph McNamara
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Publication number: 20050037908Abstract: In a booklet maker or sheet folder wherein one or more sheets are pushed through a nip formed by a pair of crease rolls, and wherein the crease rolls are driven by gears, a slip clutch is operatively disposed between one of the crease rolls and the gear driving the crease roll. The slip clutch compensates for the abrupt change in frictional coefficient experienced by the crease rolls when one or more sheets enter the nip.Type: ApplicationFiled: August 15, 2003Publication date: February 17, 2005Inventors: Raymond Ruthenberg, Joseph McNamara, David Van Wyngaarden, Steven Siu
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Publication number: 20040236084Abstract: The present invention provides substituted 2-aminopyridines of formula I, wherein R1, A1, W, X, and Y are as defined in the specification, useful in treating cell proliferative disorders.Type: ApplicationFiled: January 16, 2004Publication date: November 25, 2004Applicant: Pfizer IncInventors: Cathlin Marie Biwersi, Dennis Joseph McNamara, Joseph Thomas Repine, Peter Laurence Toogood, Scott Norman Vanderwel, Joseph Scott Warmus
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Publication number: 20040162279Abstract: The invention includes tetrahydroquinoline and related compounds of formula I, and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: ApplicationFiled: October 2, 2003Publication date: August 19, 2004Inventors: Michael Robert Barbachyn, J. Craig Ruble, Arthur Glenn Romero, Lisa Marie Thomasco, Alexander Ross Hurd, John Raymond Palmer, Peter Laurence Toogood, Dennis Joseph McNamara, Debra Ann Sherry, Paul Joseph Dobrowolski
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Publication number: 20040158065Abstract: Methods and materials for preparing irreversible inhibitors of tyrosine kinases of general Formula 1 are disclosed. Such inhibitors, which include N-[4-(3-chloro-4-floro-phenylamino)-7-(3-morpholin-4-yl-propoxy)-quinazolin-6-yl]-acrylamide, are useful for treating cancer, restenosis, atherosclerosis, endometriosis and psoriasis. The disclosed methods employ protecting schemes to minimize undesirable diacryloylamino-quinazoline side products.Type: ApplicationFiled: February 4, 2004Publication date: August 12, 2004Inventors: Hubert Barth, Alexander James Bridges, Ronald J. Heemstra, Nicole Marcia Horne, Robert Craig Hughes, Thomas Elliott Jacks, Dennis Joseph McNamara, Simon Schneider, Klaus Steiner, Peter Laurence Toogood, Roy Thomas Winters
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Patent number: 6737410Abstract: The present invention provides compounds having the structure represented by Formula I: and methods of treating cancer, restenosis, atherosclerosis, or psoriasis or preventing restenosis, and a pharmaceutical composition comprising a compound of Formula I and a pharmaceutically acceptable carrier.Type: GrantFiled: October 4, 2000Date of Patent: May 18, 2004Assignee: Warner-Lambert CompanyInventors: Annette Marian Doherty, Daniele Marie Leonard, Dennis Joseph McNamara, Kevon Ray Shuler
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Publication number: 20040006042Abstract: The present invention provides compounds of Formula II: 1Type: ApplicationFiled: May 28, 2003Publication date: January 8, 2004Inventors: David Allen Berry, Ellen Myra Dobrusin, Judith Lynne Johnson-Philipsen, Wayne Daniel Klohs, Dennis Joseph McNamara, Leslie Morton Werbel
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Patent number: D720424Type: GrantFiled: February 5, 2014Date of Patent: December 30, 2014Inventors: Daniel Joseph McNamara, Matthew Francis McNamara