Patents by Inventor Joseph Melinger

Joseph Melinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indodicarbocyanine phosphoramidites with bathochromically shifted absorption and emission, and tunable hydrophobicity
    Patent number: 12595281
    Abstract: New phosphoramidite Cy5 derivatives can be used in automated DNA synthesis, allowing the labeling of DNA sequences with a wider array of chromophores than are presently commercially available. In addition to varying dye hydrophobicity/hydrophilicity, the 5,5?-substituents (including hexyloxy, triethyleneglycol monomethyl ether, tert-butyl, and chloro groups) can modulate electron donating/withdrawing character while also tuning resulting absorption and emission properties. Modification of the Cy5 periphery enables the tuning of photophysical properties, such as absorption and emission maxima, fluorescence quantum yield, and fluorescence lifetime.
    Type: Grant
    Filed: January 27, 2023
    Date of Patent: April 7, 2026
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Igor L. Medintz, Joseph Melinger, William B. Knowlton, Bernard Yurke, Kimihiro Susumu, Sang Ho Lee, Adam Meares, Divita Mathur, Olga A. Mass, Jeunghoon Lee, Ryan D. Pensack
  • Indodicarbocyanine Phosphoramidites with Bathochromically Shifted Absorption and Emission, and Tunable Hydrophobicity
    Publication number: 20230250126
    Abstract: New phosphoramidite Cy5 derivatives can be used in automated DNA synthesis, allowing the labeling of DNA sequences with a wider array of chromophores than are presently commercially available. In addition to varying dye hydrophobicity/hydrophilicity, the 5,5?-substituents (including hexyloxy, triethyleneglycol monomethyl ether, tert-butyl, and chloro groups) can modulate electron donating/withdrawing character while also tuning resulting absorption and emission properties. Modification of the Cy5 periphery enables the tuning of photophysical properties, such as absorption and emission maxima, fluorescence quantum yield, and fluorescence lifetime.
    Type: Application
    Filed: January 27, 2023
    Publication date: August 10, 2023
    Inventors: Igor L. Medintz, Joseph Melinger, William B. Knowlton, Bernard Yurke, Kimihiro Susumu, Sang Ho Lee, Adam Meares, Divita Mathur, Olga A. Mass, Jeunghoon Lee, Ryan D. Pensack