Abstract: Provided herein are compounds of formula (II): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, p, R1, R2, R3, L1, L2, L3, R4, X1, X2, X3, and X4 are as defined herein. Also provided are methods of preparing compounds of formula (II), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.

Abstract: A water treatment device for purifying process water by filtration comprising a housing containing a filter media, having a bottom gravel bed and an upper silica bed, and a fluidizer for backwashing the filter media. Process water is tangentially introduced and caused to swirl in the housing above a filter media, before passing downwards through silica and gravel beds. The swirling increases the through capacity of the treatment device and reduces the amount of particles that would otherwise become imbedded in the filter media. Backwashing is accomplished by forcing fluid, through first and second components of the fluidizer, into the filter media. The first component is a channel formed in the manifold which provides backwash fluid to the bottom of the gravel bed. The second component provides backwash fluid at the gravel bed—silica bed interface by a series of radially spaced fluidizer arms.

Abstract: A stacking dolly system where each dolly comprises a central platform with outwardly projecting legs having downwardly depending rollers. Through the use of mating protrusions and indentations, successive dollies are brought to an engagement position with one another. Large numbers of dollies can be stacked to aid in warehousing, trucking and handling functions.

Abstract: An extruded aluminum sill member is supported by and attached to a wood base member which also supports a longitudinally extending inner wood trim member. The sill, base and trim members define a longitudinally extending cavity which receives a vertically adjustable rail member. The rail member has longitudinally spaced captive screws which are threaded into inverted T-nuts confined within laterally extending slots formed within the wood base member, and the trim member covers the slots. The sill member also extends under a jamb or mullion and a fixed side panel, and a snap-in extruded plastic cap covers the cavity under the panel and has an upwardly projecting and inwardly curved flange with a flexible lip for engaging the outer surface of the panel to form a water-tight seal.

Abstract: An extruded aluminum sill member is supported by and attached to a wood base member which also supports a longitudinally extending inner wood trim member. The sill, base and trim members define a longitudinally extending cavity which receives a vertically adjustable rail member. The rail member has longitudinally spaced captive screws which are threaded into inverted T-nuts confined within laterally extending slots formed within the wood base member, and the trim member covers the slots. The sill member also extends under a jamb or mullion and a fixed side panel, and a snap-in extruded plastic cap covers the cavity under the panel and has an upwardly projecting and inwardly curved flange with a flexible lip for engaging the outer surface of the panel to form a water-tight seal.