Patents by Inventor Joseph N. Bernadino

Joseph N. Bernadino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof via a dicarboxylate intermediate
    Patent number: 7411084
    Abstract: The present invention relates to a method of preparing a phenoxy alkanoic, alkenoic, or alkynoic acid or a salt thereof from a phenoxy containing compound via a dicarboxylate intermediate. The phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof prepared by this method are suitable for use in composition for delivering active agents via oral or other routes of administration to animals. Furthermore, the present invention relates to phenoxy dicarboxylic acids and their salts for delivering active agents, such as biologically or chemically active agents, to a target.
    Type: Grant
    Filed: September 26, 2002
    Date of Patent: August 12, 2008
    Assignee: Emisphere Technologies, Inc.
    Inventor: Joseph N. Bernadino
  • Method of preparing alkylated salicylamides via a dicarboxylate intermediate
    Patent number: 7169776
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
    Type: Grant
    Filed: January 19, 2005
    Date of Patent: January 30, 2007
    Assignee: Emisphere Technologies, Inc.
    Inventors: Joseph N. Bernadino, Doris C. O'Toole, William E. Bay
  • Method of preparing alkylated salicylamides via a dicarboxylate intermediate
    Patent number: 6900344
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
    Type: Grant
    Filed: March 21, 2001
    Date of Patent: May 31, 2005
    Assignee: Emisphere Technologies, Inc.
    Inventors: Joseph N. Bernadino, Doris C. O'Toole, William E. Bay
  • Method of preparing phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof via a dicarboxylate intermediate
    Publication number: 20040171865
    Abstract: The present invention relates to a method of preparing a phenoxy alkanoic, alkenoic, or alkynoic acid or a salt thereof from a phenoxy containing compound via a dicarboxylate intermediate. The phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof prepared by this method are suitable for use in composition for delivering active agents via oral or other routes of administration to animals. Furthermore, the present invention relates to phenoxy dicarboxylic acids and their salts for delivering active agents, such as biologically or chemically active agents, to a target.
    Type: Application
    Filed: April 7, 2004
    Publication date: September 2, 2004
    Inventor: Joseph N. Bernadino
  • Method of preparing alkylated salicylamides via a dicarboxylate intermediate
    Publication number: 20030096992
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide via a dicarboxylated salicylamide intermediate. The present invention also relates to dicarboxylic salicylamide delivery agent compounds for the delivery of active agents. Methods of administration are provided as well.
    Type: Application
    Filed: September 20, 2002
    Publication date: May 22, 2003
    Inventors: Joseph N. Bernadino, Doris C. O'Toole, William E. Bay
  • Method of preparing alkylated salicylamides
    Patent number: 6399798
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide (hereinafter referred to as a “protected/activated salicylamide”). The method comprises the steps of (a) alkylating the protected/activated salicylamide with an alkylating agent to form a protected/activated alkylated salicylamide, and (b) deprotecting and deactivating the protected/activated alkylated salicylamide, simultaneously or in any order, to form the alkylated salicylamide. The alkylated salicylamides prepared by this method are suitable for use in compositions for delivering active agents via oral or other routes of administration to animals.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: June 4, 2002
    Assignee: Emisphere Technologies, Inc.
    Inventors: David Gschneidner, Joseph N. Bernadino, William E. Bay
  • Method of preparing alkylated salicylamides
    Publication number: 20020013497
    Abstract: The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide (hereinafter referred to as a “protected/activated salicylamide”). The method comprises the steps of (a) alkylating the protected/activated salicylamide with an alkylating agent to form a protected/activated alkylated salicylamide, and (b) deprotecting and deactivating the protected/activated alkylated salicylamide, simultaneously or in any order, to form the alkylated salicylamide. The alkylated salicylamides prepared by this method are suitable for use in compositions for delivering active agents via oral or other routes of administration to animals.
    Type: Application
    Filed: August 3, 2001
    Publication date: January 31, 2002
    Applicant: EMISPHERE TECHNOLOGIES, INC.
    Inventors: David Gschneidner, Joseph N. Bernadino, William E. Bay