Patents by Inventor Joseph Nolfo
Joseph Nolfo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8353917Abstract: Provided are methods and apparatus including an injector system adapted for injecting a microchip comprising: an inserter comprising a rod or tube having a proximal and distal end and having a point at the distal end that defines a skin-piercing side of the inserter; a means for engaging the microchip near the distal end of the inserter, but removed in the proximal direction from the distal tip of the inserter, which means prevents rotation of an engaged microchip in two or three axes of rotation; and means for releasing the microchip from the inserter once the inserter has been inserted into a perforatable substrate.Type: GrantFiled: September 23, 2010Date of Patent: January 15, 2013Assignee: PharmaSeq, Inc.Inventors: Wlodek Mandecki, Hanan Davidowitz, Maryann Gruda, Edward Kuspiel, Joseph Nolfo, Ziye (Jay) Qian, Gary H. Reitnauer
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Publication number: 20110077659Abstract: Provided are methods and apparatus including an injector system adapted for injecting a microchip comprising: an inserter comprising a rod or tube having a proximal and distal end and having a point at the distal end that defines a skin-piercing side of the inserter; a means for engaging the microchip near the distal end of the inserter, but removed in the proximal direction from the distal tip of the inserter, which means prevents rotation of an engaged microchip in two or three axes of rotation; and means for releasing the microchip from the inserter once the inserter has been inserted into a perforatable substrate.Type: ApplicationFiled: September 23, 2010Publication date: March 31, 2011Applicant: Pharmaseq Inc.Inventors: Wlodek Mandecki, Hanan Davidowitz, Maryann Gruda, Edward Kuspiel, Joseph Nolfo, Ziye "Jay" Qian, Gary H. Reitnauer
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Patent number: 6968037Abstract: Multiple samples are prepared in slurry form and deposited through a funnel plate by a multiprobe liquid handler into an array of inserts situated in openings in a housing. Each insert has a recess that extends through the insert body and a filter disc situated in the recess to support the sample. The filter is held in place by an annular part which defines a channel providing access to the filter through the lower portion of the recess. A pressure differential is created across each of the filters by attaching a vacuum manifold to the bottom of the housing to simultaneously remove the liquid from each of the samples, leaving the samples in powder form. The housing is then placed in the X-ray diffractometer for sequential analysis of each of the samples, while the samples are situated in the inserts.Type: GrantFiled: April 10, 2003Date of Patent: November 22, 2005Assignee: Bristol-Myers Squibb Co.Inventors: Victor W. Rosso, Glen Young, Joseph Nolfo, Imre M. Vit z, John J. Venit
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Patent number: 6893613Abstract: The base of the modular reactor includes a frame which defines an opening into which one of a plurality of interchangeable reaction vessel carrying inserts can be removeably received. Each insert has an array of recesses adapted to receive a different number of reaction vessels of different sizes. The recesses are positioned such that all arrays are suitable for use with a standard automated liquid handier. The frame has fluid flow channels for regulating the temperature of the lower portions of the vessels. A temperature control module can be received over the base to regulate the temperature of the upper portions of the vessels for reflux reactions. The corner radii of the insert and frame opening cooperate to permit the insert to be received in the frame in only one orientation. The walls of the insert are inclined to facilitate removal by a friction fit tool.Type: GrantFiled: January 25, 2002Date of Patent: May 17, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Walter Ruediger, A. Erik Rubin, Alexander Bertok, Victor W. Rosso, Joseph Nolfo, Harold N. Weller
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Patent number: 6783737Abstract: Multiple parallel chemical reactions are performed under pressure in a reactor including a multi-row array of reaction vessels situated between a temperature control base and a fluid flow manifold. The manifold consists of an input portion connected to the fluid supply by a five-way valve and a distribution portion which includes separate parallel distribution channels, one for each row of reaction vessels. A control valve for each distribution channel is interposed between the manifold portions such that the fluid flow to each row of reaction vessels can be independently controlled. An explosion proof transparent shield can be situated between the base and manifold, surrounding the reaction vessels. The interior of the shield can be flooded with inert gas.Type: GrantFiled: January 25, 2002Date of Patent: August 31, 2004Assignee: Bristol-Myers Squibb CompanyInventors: Joseph Nolfo, Maxine Soumellant, Victor W. Rosso, Peter Lee, Mayra B. Reyes, John J. Venit
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Publication number: 20040028179Abstract: Multiple samples are prepared in slurry form and deposited through a funnel plate by a multiprobe liquid handler into an array of inserts situated in openings in a housing. Each insert has a recess that extends through the insert body and a filter disc situated in the recess to support the sample. The filter is held in place by an annular part which defines a channel providing access to the filter through the lower portion of the recess. A pressure differential is created across each of the filters by attaching a vacuum manifold to the bottom of the housing to simultaneously remove the liquid from each of the samples, leaving the samples in powder form. The housing is then placed in the X-ray diffractometer for sequential analysis of each of the samples, while the samples are situated in the inserts.Type: ApplicationFiled: April 10, 2003Publication date: February 12, 2004Inventors: Victor W. Rosso, Glen Young, Joseph Nolfo, Imre M. Vitez, John J. Venit
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Publication number: 20030143120Abstract: The base of the modular reactor includes a frame which defines an opening into which one of a plurality of interchangeable reaction vessel carrying inserts can be removeably received. Each insert has an array of recesses adapted to receive a different number of reaction vessels of different sizes. The recesses are positioned such that all arrays are suitable for use with a standard automated liquid handier. The frame has fluid flow channels for regulating the temperature of the lower portions of the vessels. A temperature control module can be received over the base to regulate the temperature of the upper portions of the vessels for reflux reactions. The corner radii of the insert and frame opening cooperate to permit the insert to be received in the frame in only one orientation. The walls of the insert are inclined to facilitate removal by a friction fit tool.Type: ApplicationFiled: January 25, 2002Publication date: July 31, 2003Inventors: Waldemar Ruediger, A. Erik Rubin, Alexander Bertok, Victor W. Rosso, Joseph Nolfo, Harold N. Weller
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Publication number: 20030143121Abstract: Multiple parallel chemical reactions are performed under pressure in a reactor including a multi-row array of reaction vessels situated between a temperature control base and a fluid flow manifold. The manifold consists of an input portion connected to the fluid supply by a five-way valve and a distribution portion which includes separate parallel distribution channels, one for each row of reaction vessels. A control valve for each distribution channel is interposed between the manifold portions such that the fluid flow to each row of reaction vessels can be independently controlled. An explosion proof transparent shield can be situated between the base and manifold, surrounding the reaction vessels. The interior of the shield can be flooded with inert gas.Type: ApplicationFiled: January 25, 2002Publication date: July 31, 2003Inventors: Joseph Nolfo, Maxine Soumellant, Victor W. Rosso, Peter Lee, Mayra B. Reyes, John J. Venit