Patents by Inventor Joseph Nti-Gyabaah

Joseph Nti-Gyabaah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of fusion proteins
    Patent number: 9556258
    Abstract: The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: January 31, 2017
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Joseph Nti-Gyabaah, Ijeoma Ikechukwu, Matthew Pettroff, Christine Cho Lee
  • CHROMATOGRAPHY PROCESS FOR RESOLVING HETEROGENEOUS ANTIBODY AGGREGATES
    Publication number: 20140288278
    Abstract: Disclosed are methods and processes utilizing multi-modal chromatography as a polishing step to separate heterogeneously charged (basic and acidic) aggregates and other impurities from partially a partially purified bulk product monoclonal antibody product. The resulting chromatographic process provides a scaleable production process that is cost effective and increases the productivity of the purification process over a platform utilizing a combination of anion and cation exchange chromatography to resolve heterogeneous aggregates.
    Type: Application
    Filed: October 25, 2012
    Publication date: September 25, 2014
    Inventors: Joseph Nti-gyabaah, Sandra Meissner, Rebecca Chmielowski, Janelle Konietzko
  • PURIFICATION OF FUSION PROTEINS
    Publication number: 20140187751
    Abstract: The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode.
    Type: Application
    Filed: July 3, 2012
    Publication date: July 3, 2014
    Applicant: MERCK
    Inventors: Joseph Nti-Gyabaah, Ijeoma Ikechukwu, Matthew Pettroff, Christine Cho Lee
  • Process for the Preparation of (R)-4,4-Dialkoxy-Pyran-3-Ols Such as (R)-4,4-Dimethoxy-Pyran-3-Ol
    Publication number: 20080138866
    Abstract: The present invention is concerned with novel processes for the preparation of (R)-4,4-dimethoxy-pyran-3-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity including CCR2 antagonists.
    Type: Application
    Filed: March 7, 2006
    Publication date: June 12, 2008
    Inventors: Jeffrey C. Moore, Birgit Kosjek, Joseph Nti-Gyabaah
  • Using amines or amino acids as mobile phase modifiers in chromatography
    Patent number: 7241866
    Abstract: This invention relates to the use of amine, amino acid and amino acid ester mobile modifiers in normal phase chromatography to improve the resolution and or productivity of peptide and lipopeptide purification. This chromatographic method can be sued for either analytical or preparative scale purification.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: July 10, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Kent E. Goklen, Joseph Nti-Gyabaah, Firoz D. Antia, Mary Ellen Dahlgren
  • Using amines or amino acids as mobile phase modifiers in chromatography
    Publication number: 20060014933
    Abstract: This invention relates to the use of amine, amino acid or amino acid ester mobile phase modifiers in normal phase chromatography to improve the resolution and/or productivity of peptide and lipopeptide purification. This chromatographic method can be used for either on analytical or preparative scale purification.
    Type: Application
    Filed: October 24, 2003
    Publication date: January 19, 2006
    Inventors: Kent Goklen, Joseph Nti-Gyabaah, Firorz Antia, Mary Dahlgren
  • Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
    Patent number: 6764842
    Abstract: The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin &agr;v&bgr;3 receptor antagonists.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: July 20, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Michael G. Sturr, Russell Fieldon Boyd, Kodzo Gbewonyo, Joseph Nti-Gyabaah, David J. Pollard, James Christopher McWilliams, Kathleen A. Telari
  • Enantioselective bioreduction for the preparation of integrin receptor antagonist intermediates
    Publication number: 20020187988
    Abstract: The present invention relates to a novel enantioselective bioreduction using a yeast microorganism for the preparation of the chiral allylic alcohols of structural formula I (R is hydrogen or methyl) which are useful in the asymmetric synthesis of integrin &agr;v&bgr;3 receptor antagonists.
    Type: Application
    Filed: March 27, 2002
    Publication date: December 12, 2002
    Inventors: Michael G. Sturr, Russell Fieldon Boyd, Kodzo Gbewonyo, Joseph Nti-Gyabaah, David J. Pollard, James Christopher McWilliams, Kathleen A. Telari