Abstract: The present invention relates to prostate cancer (PC), in particular the identification of certain bacteria in prostate cancer tissues or liquid biopsies and the use of such identification as a prognostic indicator of cancer progression. The present invention also relates to cultures of newly identified bacteria and means for identifying such bacteria in biological samples.

Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

Abstract: The present invention provides a method for depleting host nucleic acid in a biological sample, said sample having been previously obtained from an animal host and having been subjected to treatment to lyse host cells present in the sample, and optionally having been subjected to a treatment to deplete nucleic acid released from host cells within said sample or otherwise to render such nucleic acid unidentifiable, the method comprising: (a) depleting host mitochondria or host mitochondrial NA (mtDNA and/or mtRNA) present in the treated sample; and (b) extracting and/or analysing remaining nucleic acid from the treated sample. Also provided is a related kit comprising reagents for performing the method.

Abstract: Presented herein are techniques associated with replicating an OpenRoaming™ policy federation in a Third Generation Partnership Project (3GPP) network environment. For example, techniques herein provide a roaming policy federation architecture for a 3GPP network environment.

Abstract: A method of dicing a wafer includes positioning the wafer with its top side on a tape material. The wafer includes a plurality of die separated by scribe streets. A first pass being a first infrared (IR) laser beam is directed at the bottom side with a point of entry within the scribe streets. The first IR laser beam is focused with a focus point embedded within a thickness of the wafer, and has parameters selected to form an embedded crack line within the wafer. The embedded crack line does not reach the top side surface. A second pass being a second IR laser beam is directed at the bottom side having parameters selected to form a second crack line that that has a spacing relative to the embedded crack line, and the second IR laser beam causes the embedded crack line to be extended to the top side surface.

Abstract: Systems and methods for improved radiation treatment planning can employ hierarchical constrained optimization with relaxed constraints also referred to herein after as expedited hierarchical constrained optimization (ECHO). The systems and methods described herein employ a combination of constrained optimization and a correction loop involving unconstrained optimization to enhance the speed and efficiency of the radiation treatment planning process and improve the accuracy and quality of resulting radiation treatment plans. The use of a hierarchical constrained optimization approach leads to less complex and faster to solve optimization problems. The correction loop allows for compensating for optimization error associated with the sequence of constrained optimizations by incorporating such error in an unconstrained optimization. Hard and soft dose volume constraints can be efficiently incorporated.

Abstract: The present invention provides a method for depleting host nucleic acid in a biological sample, said sample having been previously obtained from an animal host and having been subjected to treatment to lyse host cells present in the sample, and having been subjected to a treatment to deplete nucleic acid released from host cells within said sample or otherwise to render such nucleic acid unidentifiable, the method comprising: (a) depleting host mitochondria or host mitochondrial DNA (mtDNA) present in the treated sample; and (b) extracting and/or analysing remaining nucleic acid from the treated sample. Also provided is a related kit comprising reagents for performing the method. Further claimed is a method for isolating mitochondrial DNA after host cells have been lysed and host cell nucleic acids have been removed from the sample.

Abstract: A computer-program product, computer-implemented method, and computer-implemented system includes obtaining a raw dataset; executing an outlier filtration process based on obtaining the raw dataset; training a model using a refined outlier-reduced dataset; and predicting, via the trained model, a value of the target entity at a future time.

Abstract: The embodiments presented within provide methods, devices, and computer readable medium involving generation of power within a device, using this power to activate the device, measuring a physical characteristic of the power indicative of an external event, and then waking the device fully based on the external event. The device remains in a low-power sleep state until being woken based on the external event.

Abstract: In examples, a method for manufacturing a semiconductor die comprises, prior to forming circuitry on a semiconductor wafer, forming a horizontal array of cracks in an interior of the wafer using a laser. The method also includes, after forming the horizontal array of cracks, forming circuitry on a device side of the wafer. The method includes forming conductive bumps on the device side of the wafer.

Abstract: The present embodiments relate to establishing secure data communication using an Elliptic-curve Diffie-Hellman ephemeral (ECDHE) key agreement procedure. Devices in a network environment can utilize a key agreement procedure to establish secure communication between multiple application layers in a micro service architecture. Particularly, a tunnel can be established between a mobile device and an encryption service by transmitting key information between the mobile device and the encryption service. This can allow for encryption keys to only be accurately generated by the mobile device and encryption service. Accordingly, intermediary nodes may be unable to decrypt the data, allowing for safe and secure transport of sensitive data.

Abstract: Systems and methods for implementing Soft-duplex functionality in an amplifier in a HFC network.

Abstract: The present technology is directed to providing enhanced capacity for tenants in a neutral host network (NHN) via multi-connectivity such as dual connectivity or carrier aggregation. The present technology can identify, at a small cell gateway, signaling traffic passing from an access network to a respective core network of an NHN operating at mid-band frequencies and add an interface between the small cell gateway of the NHN and a base station of a tenant network operating at low-band frequencies to establish dual connectivity. Furthermore, the present technology can establish a radio resource control (RRC) connection in a primary cell residing in a macro network operating at low-band frequencies and add, at a fronthaul gateway, one or more secondary cells in a small cell network operating at mid-band frequencies to enable carrier aggregation of the one or more secondary cells with the primary cell the small cell network.

Abstract: The present invention comprises a variety of embodiments which all provide an apparatus, either standalone or attached to a piece of furniture, that enables a pet to sit or lay down next to its owner, and includes safe and accommodating ascending and descending structures for the pet's mobility and comfort.

Abstract: Systems and methods for multi-modal, multi-resolution deep learning neural networks for segmentation, outcomes prediction and longitudinal response monitoring to immunotherapy and radiotherapy are detailed herein. A structure-specific Generational Adversarial Network (SSGAN) is used to synthesize realistic and structure-preserving images not produced using state-of-the art GANs and simultaneously incorporate constraints to produce synthetic images. A deeply supervised, Multi-modality, Multi-Resolution Residual Networks (DeepMMRRN) for tumor and organs-at-risk (OAR) segmentation may be used for tumor and OAR segmentation. The DeepMMRRN may combine multiple modalities for tumor and OAR segmentation. Accurate segmentation may be realized by maximizing network capacity by simultaneously using features at multiple scales and resolutions and feature selection through deep supervision. DeepMMRRN Radiomics may be used for predicting and longitudinal monitoring response to immunotherapy.

Abstract: A monitoring system of the present disclosure has at least one voltage sensor or current sensor in a housing that is directly coupled to a bushing or a secondary side cable of a distribution transformer within an electrical grid and that detects a voltage or current in the bushing or a secondary side cable of a distribution transformer. Further, the monitoring system has at least one environmental sensor that detects information in an environment of the distribution transformer and a processor that monitors the detected information and determines if the information indicates a scenario in the environment or the electricity grid for which an alert to personnel may be warranted thereby transmitting a message to a central computing device regarding condition awareness so that remedial action may be taken by the personnel.

Abstract: An apparatus operating as a certificate authority (CA) is described. The apparatus can perform operations including receiving, from a plurality of requesting devices, a request to join a group. The request can include identification information for the group and attestation evidence for the plurality of requesting devices. Responsive to receiving the request, the apparatus can provide a group certificate for the group to the plurality of requesting devices.

Abstract: In a described example, a method includes thinning a first side of a semiconductor substrate, in which a plurality of dies are formed on a second side of the substrate opposite the first side and separated from each other by scribe streets of the substrate. The method also includes directing a laser beam at the first side with an entry point along a scribe street thereof, in which the laser beam is focused inside the substrate to form at least one modified region within the substrate at a location spaced apart from the first side and at least one crack propagates from the modified region toward the first side. The method also includes electrically testing the dies on the substrate, in which the dies being tested are located between the modified regions of respective scribe streets of the substrate.

Abstract: A bioprinter for fabricating three-dimensional (3D) cell constructs, the bioprinter comprising one or more holding reservoirs for holding a fluid sample; a printstage for holding a sample container and supporting a substrate on which a 3D cell construct is to be printed; a sample loading system in fluid communication with the one or more holding reservoirs, the sample loading system configured to load a sample from a sample container into the one or more holding reservoirs; a pump in fluid communication with the sample loading system, the pump configured to draw the sample out of a sample container and pump the sample into the one or more holding reservoirs; and a droplet dispensing system in fluid communication with the one or more reservoirs, the droplet dispensing system configured to print sample droplets from the one or more reservoirs onto a substrate supported by the printstage.