Abstract: A method delivers fuel gas to a furnace combustion chamber from a premix burner having a reaction zone with an outlet to the furnace combustion chamber. This includes the steps of injecting a premix of primary fuel gas and combustion air into the reaction zone, and combusting the premix to provide combustion products including vitiated combustion air in the reaction zone. Further steps include injecting staged fuel gas into the reaction zone separately from the premix, discharging the staged fuel gas and vitiated combustion air from the reaction zone through the outlet to the furnace combustion chamber, and combusting the staged fuel gas and vitiated combustion air in the furnace combustion chamber. This enables low NOx combustion in the furnace combustion chamber to be achieved as a result of interacting the staged fuel gas with the vitiated combustion air in the reaction zone.

Abstract: Systems, methods, compositions, and the like, such as diagnostics, medicaments, and therapeutics, etc., relating to Neuropeptide FF2 Receptor, also known as GPR74. Such diagnostics and therapeutics, etc., include for example the nucleic acids, peptides, proteins, etc., of GPR74, as well as antibody and nucleic acid based compositions, treatments, assays, agonists, antagonists, probes, antisense, and gene therapies. The diagnosis, treatment, inhibition, etc., can be, for example, of Alzheimer's disease, of diseases of myocytes, such as myocardial infarct and diabetes-related conditions and congestive heart failure, and of Parkinson's disease.

Abstract: This invention relates to the discovery of nucleic acids and proteins associated with aging processes. The identification of these aging-associated nucleic acids and proteins have diagnostic uses in detecting the aging status of a cell population as well as application for treating or delaying cellular and physiological changes that occur with aging or the onset of diseases typically associated with aging.

Abstract: The present invention comprises systems, methods, compositions and the like, such as diagnostics, medicaments and therapeutics, relating to GPR 38 and Alzheimer's disease and Parkinson's disease, inflammatory bowel diseases including ulcerative colitis and Crohn's disease, Hodgkin's disease, glioblastoma and carcinomas including breast, colon, lung (small cell and adenocarcinoma) pancreatic (small cell and adenocarcinoma), ovarian, and prostate. Such diagnostics and therapeutics include peptide, protein, antibody and nucleic acid based compositions, including agonists, antagonists, probes, antisense and gene therapy compositions.

Abstract: Diagnostics, therapeutics and the like based on anaphylatoxin C3a receptor directed against Alzheimer's disease and Parkinson's disease. The compositions and methods and the like can include one or more of peptide, protein, antibody, and nucleic acid components, and can be useful, for example, as agonists, antagonists, probes, antisense and gene therapy compositions and otherwise as may be desired.

Abstract: Systems, methods, compositions, and the like, such as diagnostics, medicaments, and therapeutics relating to CCXCR1 and allergic rhinitis, rheumatoid arthritis, cancers including ovarian, colonic, pancreatic, and prostatic carcinoma, and wound healing. Such diagnostics and therapeutics include peptide, protein, antibody, and nucleic acid based compositions, including agonists, antagonists, probes, antisense, and gene therapy compositions.

Abstract: The present invention provides antigenic peptides for GPCRs and antibodies relating thereto, and related systems, methods, compositions, and the like, such as diagnostics and medicaments. Where antibodies against a given GPCR are not known, the present invention provides such antibodies, and preferred antigenic sequences for producing such antibodies. Where antibodies against a given GPCR are known, the present invention provides preferred antigenic peptides for producing antibodies that exhibit improved specificity, affinity or capacity to perform antibody-related actions relative to the known antibodies.

Abstract: This invention relates to the discovery of nucleic acids associated with cell proliferation, cell cycle arrest, cell death and premature aging and uses therefor.

Abstract: This invention relates to the discovery of the association of certain nucleic acid sequences and proteins with breast cancer, the use of such sequences as a diagnostic indicator and treatments based on the association.

Abstract: The present invention relates to the discovery of nucleic acids and proteins that are markers for specific normal or cancerous tissues. The identification of these markers has diagnostic uses in detecting cancer in a subject, as well as in determining the tissue of origin for a cancerous cell. These tissue-specific molecules further allow the tissue specific expression of a polynucleotide or protein of interest. In addition, the tissue-specific molecules of the invention have therapeutic applications for targeting compounds to a tissue of interest.

Abstract: This invention relates to the discovery of nucleic acids and proteins associated with the aging processes, such as cell proliferation and senescence. The identification of these aging-associated nucleic acids and proteins have diagnostic uses in detecting the aging status of a cell population as well as applications for gene therapy and the delaying of the aging process.

Abstract: This invention relates to the discovery of nucleic acids and proteins associated with the aging processes, such as cell proliferation and senescence, and in particular with skin aging. The identification of these aging-associated nucleic acids and proteins have diagnostic uses in detecting the aging status of a cell population as well as application for gene therapy and the delaying of the aging process.

Abstract: A flow control valve arrests fluid flow from a primary line to a branch line when flow into the branch line exceeds a predetermined flow rate. In one embodiment for use with an irrigation system, the valve includes a T-fitting. The fitting defines a primary passage, which communicates with irrigation pipes, and a branch passage, which communicates with a riser and sprinkler assembly. A valve seat is located within a housing that couples with the fitting. The valve seat is located within the T-fitting when the valve is assembled. The location of the valve seat within the fitting allows the valve to function even when the riser and/or a portion of the housing is sheared off. A stopper selectively engages a valve seat to inhibit water flow through the branch passage when the flow rate through the branch passage exceeds the predetermined flow rate.

Abstract: A fluid flow control valve within a pop-up sprinkler arrests fluid flow through a riser of the pop-up sprinkler under abnormal flow conditions, such as when the riser is broken or a sprinkler head is removed from the riser. The riser, which is movable relative to a housing of the pop-up sprinkler, is attached to a sprinkler head which distributes water to the surrounding area. A valve seat device is disposed within the riser. A stopper is positioned within a valve passageway defined by the valve seat device. The stopper selectively engages the valve seat to inhibit water flow through the riser under abnormal flow conditions. A biasing device prevents the stopper from engaging with the valve seat under normal flow conditions. A fluid flow control valve assembly within a swing joint of an irrigation system includes a first within a first elbow fitting and a second valve within a second elbow fitting. The first and second elbow fittings are movable relative to each other and together form the swing joint.

Abstract: A flow control valve arrests fluid flow from a primary line to a branch line when flow into the branch line exceeds a predetermined flow rate. In one embodiment for use with an irrigation system, the valve includes a T-fitting. The fitting defines a primary passage, which communicates with irrigation pipes, and a branch passage, which communicates with a riser and sprinkler assembly. A valve seat is located within a housing that couples with the fitting. The valve seat is located within the T-fitting when the valve is assembled. The location of the valve seat within the fitting allows the valve to function even when the riser and/or a portion of the housing is sheared off. A stopper selectively engages a valve seat to inhibit water flow through the branch passage when the flow rate through the branch passage exceeds the predetermined flow rate.

Abstract: A flow control valve arrests fluid flow from a primary line to a branch line when flow into the branch line exceeds a predetermined flow rate. In one embodiment for use with an irrigation system, the valve includes a T-fitting. The fitting defines a primary passage, which communicates with irrigation pipes, and a branch passage, which communicates with a riser and sprinkler assembly. A valve seat is located within a housing that couples with the fitting. The valve seat is located within the T-fitting when the valve is assembled. The location of the valve seat within the fitting allows the valve to function even when the riser and/or a portion of the housing is sheared off. A stopper selectively engages a valve seat to inhibit water flow through the branch passage when the flow rate through the branch passage exceeds the predetermined flow rate.

Abstract: This invention provides methods for the isolation of complete representation of cellular messenger ribonucleic acid from wax-embedded tissue samples. Expression of genes of interest can thus be fortuitously determined and cDNA probes can be readily developed.

Abstract: A disposable cover for an infrared thermometer provides IR window isolation of handling and usage generated forces. The cover comprises a thin sidewall linked to the film window with a collar structure. The collar structure includes one or more characteristics that either isolate the film window from externally applied forces, or develops counter forces in a way that precludes film stretching and other transmission distorting effects. In a preferred embodiment, the probe includes retention ears and the cover includes a rim that cooperatively engages the retention ears. This combination of retention ears and an interlocking rim decreases movement of the cover along the probe axis. The cover of the present invention permits sanitary application of an infrared clinical thermometer without hindering reading accuracy or patient comfort.

Abstract: Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.

Abstract: The present invention provides gene subtraction methods that can be used to identify and isolate from hybridization mixtures differentially expressed nucleic acid and/or commonly expressed nucleic acid between two populations of nucleic acid. The methods of the present invention employ a restriction endonuclease recognition site that is also recognized in whole or in part by a second restriction endonuclease (e.g., HinPI and BssHII or HhaI and HinP1I) to create different ends (e.g., sticky ends) between the first and second nucleic acid populations. In addition, the methods of the present invention use a selective ligation step, a biotinylated nucleotide extension step, or both to differentiate between homoduplexes, which allow for the identification of sequences that are different between the two nucleic acid populations, and heteroduplexes, which allow for the identification of sequences that are common to the two nucleic acid populations.