Abstract: A Transcranial Magnetic Stimulator (TMS) is used by a patient to treat a variety of human disorders including migraine headaches. The device has an electronic device to charge a capacitor to a high voltage which creates a high current in a magnetic coil which produces an intense magnetic pulse applied to the patient's head for treatment of migraine headaches or to other patient body parts to treat other disorders. The TMS may be reprogrammed remotely over the Internet to add additional pulses or additional time that the patient may use the TMS, during which time the TMS would continue to function. The data in the TMS may be sent over the Internet to the patient's physician and/or to a monitor to send the data to the company that manufactured the TMS.

Abstract: A transcranial magnetic stimulation (TMS) device has at least one capacitor. A charging circuit charges the capacitor. The TMS device includes a magnetic coil for delivering magnetic pulses to a person's body. A bleed resistor is within the TMS device to minimize forces applied to the bleed resistor where the bleed resistor is aligned with magnetic field lines generated by the magnetic pulses.

Abstract: A transcranial magnetic stimulation (TMS) device for the treatment of migraine headaches which includes at least one capacitor as well as a charging circuit for charging the capacitor contained in the TMS device. A magnetic coil delivers a magnetic pulse upon discharge of the capacitor. Inner and outer end wire segments of the magnetic coil are oriented parallel to a direction of magnetic field lines of the magnetic pulse.

Abstract: A Transcranial Magnetic Stimulator (TMS) is used by a patient to treat a variety of human disorders including migraine headaches. The device has an electronic device to charge a capacitor to a high voltage which creates a high current in a magnetic coil which produces an intense magnetic pulse applied to the patient's head for treatment of migraine headaches or to other patient body parts to treat other disorders. The TMS has a geometric shape where each one of the patient's thumbs passes through a hole formed into the cover of the TMS and as many as the four fingers of each hand may be placed into a groove in the cover to accommodate the patients fingers and provide a secure holding mechanism.

Abstract: Devices, apparatus and methods are disclosed for carrying out processing steps involved in chemical reactions such as hybridization reactions conducted on the surface of a substrate comprising chemical compounds such as biopolymer features. A device comprises a housing comprising a housing chamber. The housing comprises an opening through which a substrate may be inserted into the housing chamber. The device may also comprise a lift mechanism for moving the substrate in and out of the housing chamber in a controlled manner. At least one inlet may be in fluid communication with the housing chamber and at least one outlet may be in fluid communication with the housing chamber. Also disclosed are methods wherein the surface is brought into contact with a processing fluid; and, then, the surface is removed from contact with the fluid in a controlled manner at a rate that substantially eliminates droplet formation of the fluid on the surface of the substrate.

Abstract: Methods and compositions for detecting cross-contamination between samples contacted with different arrays of a multi-array substrate are provided. The methods involve contacting sample to arrays of a multi-array substrate that contains cross-contamination probes in each of its arrays, and evaluating the resultant sample contacted arrays for cross-contamination between the samples. In many embodiments, the arrays of the multi-array substrate contain a set of cross-contamination probes for a corresponding set of cross-contamination targets in the sample(s). Kits and systems are provided for performing the invention. The subject methods may be used in a variety of different applications, such as gene expression analysis, DNA sequencing, mutation detection, as well as other genomics and proteomics applications.

Abstract: Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed.

Abstract: Apparatus and methods are disclosed for conducting chemical reactions. The apparatus comprises a plurality of wells in a housing and a channel in the housing. The channel surrounds the plurality of wells and is adapted for filling with an amount of a fluid to form a convex meniscus extending above the top of the channel. In the method one or more liquid samples are placed in separate wells in a housing surface comprising a plurality of the wells. The volume of the liquid sample in each of the wells is sufficient to form a convex meniscus at the surface of each of the wells. The liquid samples are contacted with a plurality of arrays of chemical compounds. In one approach, the liquid samples are contacted with a substrate surface having a plurality of arrays of chemical compounds arranged on the substrate surface. Each of the arrays corresponds to a respective well in the housing.

Abstract: Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed.