Patents by Inventor Joseph P. McClurg

Joseph P. McClurg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
    Patent number: 9296699
    Abstract: The present invention provides compositions of 6-amino morphinan compounds and process for their synthesis. In particular, the processes provide for the reductive amination of 6-keto morphinans by catalytic transfer hydrogenation, to produce 6-amino morphinan compounds, which are epimerically and/or diastereomerically enriched.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: March 29, 2016
    Assignee: MALLINCKRODT LLC
    Inventors: Christopher W. Grote, Joseph P. McClurg, John E. Johnson, Jr., Sarah M. Farris
  • Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
    Patent number: 8519133
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: August 27, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
    Patent number: 8471023
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: June 25, 2013
    Assignee: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Reductive Amination of 6-Keto Morphinans by Catalytic Hydrogen Transfer
    Publication number: 20120316343
    Abstract: The present invention provides compositions of 6-amino morphinan compounds and process for their synthesis. In particular, the processes provide for the reductive amination of 6-keto morphinans by catalytic transfer hydrogenation, to produce 6-amino morphinan compounds, which are epimerically and/or diastereomerically enriched.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 13, 2012
    Applicant: Mallinckrodt LLC
    Inventors: Christopher W. Grote, Joseph P. McClurg, John E. Johnson, JR., Sarah M. Farris
  • Process and compounds for the production of (+)opiates
    Patent number: 8252808
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of (+)-opiates. Non-limiting examples of (+) opiates that may be derived from one or more compounds of the invention include (+)-noroxymorphone, (+)-naltrexone, (+)-naloxone, (+)-N-cyclopropylmethylnorhydrocodone, (+)-N-cycloproylmethylnorhydromorphone, (+)-N-allylnorhydrocodone, (+)-N-allylnorhydromorphone, (+)-noroxycodone, (+)-naltrexol, (+)-naloxol, and (+)-3-O-methyl-naltrexone.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: August 28, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Todd Osiek, Subo Liao, Frank W. Moser, Joseph P. McClurg
  • Remove Amination of 6-Keto Normorphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317861
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Preparation of 6-Alpha-Amino N-Substituted Morphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317683
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Process and compounds for the production of (+)opiates
    Publication number: 20090156818
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of (+)-opiates. Non-limiting examples of (+) opiates that may be derived from one or more compounds of the invention include (+)-noroxymorphone, (+)-naltrexone, (+)-naloxone, (+)-N-cyclopropylmethylnorhydrocodone, (+)-N-cycloproylmethylnorhydromorphone, (+)-N-allylnorhydrocodone, (+)-N-allylnorhydromorphone, (+)-noroxycodone, (+)-naltrexol, (+)-naloxol, and (+)-3-O-methyl-naltrexone.
    Type: Application
    Filed: December 17, 2008
    Publication date: June 18, 2009
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Todd Osiek, Subo Liao, Frank W. Moser, Joseph P. Mcclurg