Patents by Inventor Joseph P. Noel

Joseph P. Noel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of making modified polypeptides
    Patent number: 6468772
    Abstract: Novel polypeptides and the corresponding nucleic acids encoding such polypeptides are disclosed herein. The invention provides methods of making modified polypeptides by altering one or more amino acid residues involved in the active site of a preselected polypeptide.
    Type: Grant
    Filed: September 17, 1999
    Date of Patent: October 22, 2002
    Assignees: The Salk Institute for Biological Studies, The University of Kentucky Research Foundation
    Inventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
  • Synthases
    Publication number: 20020094556
    Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase with or without a substrate bound in the active site.
    Type: Application
    Filed: June 22, 2001
    Publication date: July 18, 2002
    Applicant: The University of Kentucky Research Foundation
    Inventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
  • Synthases
    Publication number: 20020094557
    Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase. with or without a substrate bound in the active site.
    Type: Application
    Filed: July 11, 2001
    Publication date: July 18, 2002
    Applicant: The University of Kentucky Research Foundation
    Inventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
  • Synthases
    Publication number: 20020040488
    Abstract: Novel synthases and the corresponding nucleic acids encoding such synthases are disclosed herein. Such synthases possess an active site pocket that includes key amino acid residues that are modified to generate desired terpenoid reaction intermediates and products. Synthase modifications are designed based on, e.g., the three-dimensional coordinates of tobacco 5-epi-aristolochene synthase, with or without a substrate bound in the active site.
    Type: Application
    Filed: June 29, 2001
    Publication date: April 4, 2002
    Applicant: The University of Kentucky Research Foundation, Kentucky corporation
    Inventors: Joseph Chappell, Kathleen R. Manna, Joseph P. Noel, Courtney M. Starks
  • PEDTIDYL-PROLYL CIS-TRANS ISOMERASE INHIBITORS AND USES THEREFORE
    Publication number: 20010016346
    Abstract: The invention relates to inhibitors of PPIase activity and pharmaceutical compositions containing such inhibitors. Such compounds are useful for treatment of disorders characterized by inappropriate cell proliferation. In particular the compounds disclosed herein inhibit the activity of members of the Pinl/parvulin class of PPIases. These compounds have been designed based on the high resolution X-Ray derived crystal structure of the human enzyme Pin1.
    Type: Application
    Filed: June 9, 1998
    Publication date: August 23, 2001
    Inventors: JOSEPH P. NOEL, TONY R. HUNTER