Abstract: A tissue processing system includes a tray and a processing component. The processing component has teeth configured to dice, mince, and mix the tissue in the tray. In some versions, teeth of a rotary member mesh with teeth of a stationary member, such that the tissue is ground between the meshing teeth. The rotary member may be moved in an orbital path relative to the stationary member. In some versions, the teeth of two rotary members mesh together, and the rotary members are rotated in opposite directions to grind the tissue. The rotary members may also be alternatingly moved up and down to perform initial dicing on the tissue. Once the tissue has been processed, the tissue may then be used in a therapeutic manner, such as by being incorporated with a scaffold and then implanted in the same patient from whom the tissue was originally harvested.

Abstract: A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice.

Abstract: A tissue dicing and separation device comprises a housing having an interior that receives tissue for dicing and separation. The device includes a blade assembly connected to a motor and solenoid. The solenoid reciprocates the blade assembly while the motor clocks the blade assembly during each reciprocation cycle. This reciprocating and clocking action of the blade assembly dices and/or minces the tissue. The housing is filled with a fluid and then the blade assembly is continuously rotated to create a vortex within the housing. The vortex causes the diced tissue particles to separate by particle size. Outlets at different positions along the housing permit withdrawal of a slurry of fluid and tissue particles with the tissue particles having a desired size range. The obtained slurry may be used in conjunction with a fistula plug treatment device and method.