Patents by Inventor Joseph P. Steiner

Joseph P. Steiner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolidine derivative hair growth compositions and uses
    Patent number: 6177455
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: January 23, 2001
    Assignee: Gpi Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
    Patent number: 6172087
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using N-oxides of heterocyclic esters, amides, thioesters, or ketones.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: January 9, 2001
    Assignee: GPI NIL Holding, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Small molecule inhibitors of rotamase enzyme activity
    Patent number: 6140357
    Abstract: This invention relates to neurotrophic N-glyoxylprolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: April 8, 1997
    Date of Patent: October 31, 2000
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Stimulating nerve growth with immunophilins
    Patent number: 6080753
    Abstract: Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: June 27, 2000
    Assignee: Johns Hopkins University School of Medicine
    Inventors: W. Ernest Lyons, Edwin B. George, Ted M. Dawson, Joseph P. Steiner, Solomon H. Snyder
  • N-oxides of heterocyclic esters, amides, thioesters, and ketones
    Patent number: 6054452
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: July 9, 1998
    Date of Patent: April 25, 2000
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner, Eric S. Burak
  • Inhibitors of rotamase enzyme activity
    Patent number: 6022878
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: February 8, 2000
    Assignees: GPI NIL Holdings, Inc., John Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • N-linked sulfonamide of heterocyclic thioester hair growth compounds and uses
    Patent number: 6004993
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using N-linked sulfonamides of heterocyclic thioesters.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: December 21, 1999
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Method of using neurotrophic sulfonamide compounds
    Patent number: 5968957
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule piperidine and pyrrolidine sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 23, 1998
    Date of Patent: October 19, 1999
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Pyrrolidine carboxylate hair revitalizing agents
    Patent number: 5945441
    Abstract: This invention relates to methods of treating hair loss, through hair revitalization and germination, by administering non-immunosuppresive pyrrolidine carboxylate compounds.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: August 31, 1999
    Assignee: Gpi Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors
    Patent number: 5898029
    Abstract: Immunophilin ligands act by binding to receptor proteins, immunophilins, which in turn can bind to and regulate the Ca.sup.2+ dependent phosphatase, calcineurin, and the Ca.sup.2+ release channel, the ryanodine receptor. Immunophilin ligands have been discovered to enhance neurite outgrowth in neuronal cell systems by increasing sensitivity to neurotrophic factors. The effects of the immunophilin ligands are detected at subnanomolar concentrations indicating therapeutic application in diseases involving neural degeneration.
    Type: Grant
    Filed: April 12, 1994
    Date of Patent: April 27, 1999
    Assignee: The John Hopkins University
    Inventors: W. Ernest Lyons, Edwin B. George, Ted M. Dawson, Joseph P. Steiner, Solomon H. Snyder
  • Small molecule inhibitors of rotamase enzyme activity
    Patent number: 5859031
    Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: May 21, 1996
    Date of Patent: January 12, 1999
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity
    Patent number: 5846981
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: December 8, 1998
    Assignees: GPI NIL Holdings Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • N-oxides of heterocyclic esters, amides, thioesters, and ketones
    Patent number: 5846979
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters, amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: December 8, 1998
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner, Eric S. Burak
  • Inhibitors of rotamase enzyme activity
    Patent number: 5843960
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: December 1, 1998
    Assignees: GPI Nil Holdings, Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Rotamase enzyme activity inhibitors
    Patent number: 5801197
    Abstract: This invention relates to the method of using specially formulated neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: September 1, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Inhibitors of rotamase enzyme activity
    Patent number: 5798355
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 25, 1998
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Small molecule inhibitors of rotamase enzyme activity
    Patent number: 5795908
    Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: January 23, 1997
    Date of Patent: August 18, 1998
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Method of using neurotrophic sulfonamide compounds
    Patent number: 5721256
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: February 24, 1998
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
    Patent number: 5696135
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: December 9, 1997
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins Univ. School of Medicines
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton
  • Small molecule inhibitors of rotamase enzyme
    Patent number: 5614547
    Abstract: This invention relates to neurotrophic compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 25, 1997
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner