Patents by Inventor Joseph Parrella
Joseph Parrella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11679349Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: GrantFiled: May 10, 2021Date of Patent: June 20, 2023Assignee: EMD Millipore CorporationInventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Patent number: 11617988Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.Type: GrantFiled: December 3, 2018Date of Patent: April 4, 2023Assignee: EMD Millipore CorporationInventors: Herbert Lutz, Joseph Parrella, Bala Raghunath
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Publication number: 20220176278Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: ApplicationFiled: February 28, 2022Publication date: June 9, 2022Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Patent number: 11278827Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: GrantFiled: May 31, 2019Date of Patent: March 22, 2022Assignee: EMD Millipore CorporationInventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Publication number: 20210324369Abstract: The present invention provides, among other things, methods for purifying high quality messenger (mRNA) suitable for clinical use. The present invention is, in part, based on surprising discovery that capping and tailing mRNA in reaction buffer having a pH lower than 8.0 and MgCl2 at a concentration of less than 1.25 mM can increase RNA integrity of final mRNA product. Thus, the present invention provides an effective, reliable, and efficient method of manufacturing high quality RNA at large scale for therapeutic use.Type: ApplicationFiled: February 10, 2021Publication date: October 21, 2021Inventors: Jonathan Abysalh, Jorel Vargas, Cameron M. Smith, Joseph Parrella, Frank DeRosa
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Publication number: 20210260504Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: ApplicationFiled: May 10, 2021Publication date: August 26, 2021Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Patent number: 11040310Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.Type: GrantFiled: December 3, 2018Date of Patent: June 22, 2021Assignee: EMD Millipore CorporationInventors: Herbert Lutz, Joseph Parrella, Bala Raghunath
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Patent number: 11033839Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: GrantFiled: December 3, 2018Date of Patent: June 15, 2021Assignee: EMD Millipore CorporationInventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Publication number: 20190282937Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: ApplicationFiled: May 31, 2019Publication date: September 19, 2019Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Patent number: 10350518Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: GrantFiled: August 28, 2015Date of Patent: July 16, 2019Assignee: EMD Millipore CorporationInventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Publication number: 20190099717Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.Type: ApplicationFiled: December 3, 2018Publication date: April 4, 2019Inventors: Herbert Lutz, Joseph Parrella, Bala Raghunath
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Publication number: 20190099716Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.Type: ApplicationFiled: December 3, 2018Publication date: April 4, 2019Inventors: Herbert Lutz, Joseph Parrella, Bala Raghunath
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Publication number: 20190099702Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: ApplicationFiled: December 3, 2018Publication date: April 4, 2019Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Patent number: 10207225Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.Type: GrantFiled: June 11, 2015Date of Patent: February 19, 2019Assignee: EMD Millipore CorporationInventors: Herbert Lutz, Joseph Parrella, Bala Raghunath
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Patent number: 10195550Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: GrantFiled: August 28, 2015Date of Patent: February 5, 2019Assignee: EMD Millipore CorporationInventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Publication number: 20160059160Abstract: Methods of filtering a liquid feed are disclosed. In one version, the method comprises passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system. In another version, the method of filtering a liquid feed, comprises passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: ApplicationFiled: August 28, 2015Publication date: March 3, 2016Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Publication number: 20160059159Abstract: A method of filtering a liquid feed is described, comprising passing a liquid feed through a single pass tangential flow filtration (SPTFF) system and recovering the retentate and permeate from the system in separate containers. A method of filtering a liquid feed is also described comprising passing a liquid feed through a tangential flow filtration (TFF) system, recovering permeate and a portion of the retentate from the system in separate containers without recirculation through the TFF system, and recirculating the remainder of the retentate through the TFF system at least once. The methods of the invention can be performed using an SPTFF or a TFF system that comprises manifold segments to serialize the flow path of the feed and retentate without requiring diverter plates.Type: ApplicationFiled: August 28, 2015Publication date: March 3, 2016Inventors: Jonathan Steen, Mikhail Kozlov, Herbert Lutz, Joseph Parrella, Elizabeth M. Goodrich, Bala Raghunath
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Publication number: 20150360180Abstract: The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.Type: ApplicationFiled: June 11, 2015Publication date: December 17, 2015Inventors: Herbert Lutz, Joseph Parrella