Abstract: The present disclosure relates to heterobifunctional molecules, referred to as cytotoxicity targeting chimeras (CyTaCs) or antibody recruiting molecules (ARMs) that are able to simultaneously bind a target cell-surface protein as well as an exogenous antibody protein. The present disclosure also relates to agents capable of binding to a receptor on a surface of a pathogenic cell and inducing the depletion of the pathogenic cell in a subject for use in the treatment of cancer, inflammatory diseases, autoimmune diseases, viral infection, or bacterial infection.

Abstract: A control system provides automated control of gas washout of a patient interface, such as a mask or nasal prongs. A gas washout vent assembly of the system may include a variable exhaust area such as one defined by overlapping apertures of the assembly or a conduit having a variable gas passage channel. The vent assembly may be formed by nested structures, such as conic or cylindrical members, each having an opening of the overlapping apertures. The vent assembly may be attached substantially near or included with the patient interface. An actuator of the assembly, such as a solenoid or voice coil, manipulates an aperture of the vent assembly. The actuator may be configured for control by a controller to change the exhaust area of the vent assembly based on various methodologies including, for example, sleep detection, disordered breathing event detection, rebreathing volume calculation and/or leak detection.

Abstract: Devices, methods and techniques related to the use of a photoconductive semiconductor switch (PCSS) to drive a high-power laser diode for a wide range of pulse widths are disclosed. In one example aspect, a circuit for driving one or more laser diodes includes an input port configured to be coupled to a voltage input, one or more inductors that are configured to be in series with the one or more laser diodes, a photoconductive switch coupled with the one or more inductors, and an output port configured to be coupled to the one or more laser diodes.

Abstract: A piezoelectric device manufactured using a substrate with a piezoelectric moldable layer. A stamp comprising a repeating pattern of unit cells formed by a grid of interconnected sidewalls separating respective apertures is used in a molding process comprising pushing the stamp into the moldable layer causing the piezoelectric material to be pushed into the respective apertures and form an array of pillars. In the stamp, the fraction of open area, formed by a respective aperture, is more than the fraction of solid area, formed by the surrounding sidewalls. In the resulting pillar structure the fraction of active area, formed by the pillars is more than the fraction of inactive area between the pillars. The stamp can be adapted to improve structural integrity while using relatively thin sidewalls.

Abstract: Systems and methods are directed toward a platform resiliency authority that may be used to identify a component capability to manage one or more update requests using on-component structures. When an update request is received, a component capability level may be determined and, if the component is unable to perform each of a protection, a detection, and a recovery operation on-component, additional update information may be identified and used to cause the update to be installed for the component.

Abstract: An aerosol generating component including a plurality of elongate heating portions extending between terminal portions, wherein an elongate aperture is provided between adjacent heating portions, wherein the at least one elongate aperture tapers longitudinally.

Abstract: The factor Xia inhibitor milvexian has therapeutic properties useful in the treatment and/or prevention of thrombotic and thromboembolic disorders.

Abstract: An aerosol generating component including at least two substantially planar portions, wherein at least two of the substantially planar portions lie in a different plane from each other.

Abstract: An aerosol provision system 1 comprises a battery 16 for providing power to an aerosol generator 40 and a sensor for generating sensor data over a predetermined period of time. Control circuitry 18 is configured to process the sensor data and charge level data relating to the charge level in the battery 16 to determine whether a notification should be generated. In response to determining that the notification should be generated, the control circuitry 18 generates a notification signal for output from an output device 200, which may be a suggestion to recharge the battery 16 in a predetermined different way to improve the performance of the battery 16 in the longer term. The sensor may comprise a temperature sensor, and the notification may suggest to recharge the battery in a warmer or a cooler location. Alternatively, the suggestion may be not to recharge the battery for so long or not to interrupt charging until the battery is fully charged.

Abstract: Systems and methods are presented herein for a hinge assembly for adjusting, removing, and reinstalling a panel on a vehicle. The hinge assembly comprises a mount fixedly attached to a surface. A hinge body is affixed to the mount by a first hinge. A bracket is fixedly attached to a panel coupled to the hinge body by a second hinge. A release lever is configured to release the bracket from the hinge body.

Abstract: The invention relates to a method for producing an antimicrobially effective composite material (10), in which at least one molybdenum and/or tungsten containing inorganic compound is bound to at least one further material. Furthermore, the invention relates to an antimicrobially effective composite material (10), which includes at least one molybdenum and/or tungsten containing compound, which is bound to at least one further material.

Abstract: An article for use as part of a non-combustible aerosol provision system, the article including an aerosol generating component; and an aerosol generating material transfer component configured to transfer aerosol generating material to the aerosol generating component, wherein the aerosol generating component and the aerosol generating material transfer component are magnetically connected to each other.

Abstract: An aerosol generating component including a material having a grain, wherein the orientation of the grain of the material is substantially orthogonal to an axis upon which electrical connectors of the aerosol generating component are located.

Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.

Abstract: A cloud security control platform and method enforces security controls across multiple cloud environments, services and disparate teams while providing a frictionless “Permissions on Demand” mechanism for approvals and exceptions. In contrast to the prior art, security is evaluated on a permission by permission basis, with the default being that all permissions are denied and then only given to a particular identity on an as-needed basis. This approach reduces the security risks associated with the vast capabilities available in Public Cloud environments and permits an organization that uses the platform to grant access, approve exceptions and delegate approvals with the appropriate compliance.

Abstract: An aerosol provision system (1) for generating an aerosol, wherein the aerosol provision system (1) comprises a sensor (95), comprising a microphone (97), for detecting the voice of a user of the aerosol provision system (1). The aerosol provision system further comprises control circuitry (16) which is configured to receive sensor data from the sensor; determine from the sensor data whether the sensor data satisfies a predetermined criterion; and perform an operation of the aerosol provision system (1) in response to determining that both i) the sensor data satisfies the predetermined criterion and ii) an actuator 98 from the aerosol provision system (1) is being operated.

Abstract: An assembly for a dual-walled component of a gas turbine engine and methods of forming and repairing a dual-walled component. The assembly includes a cold section part having an outer surface that defines a plurality of impingement apertures, a hot section part including a pre-sintered preform, the hot section part positioned over the outer surface of the cold section part, and a plurality of support structures including the pre-sintered preform, the plurality of support structures positioned between the hot section part and the cold section part, the plurality of support structures separating the hot section part from the cold section part to define at least one cooling channel therebetween.

Abstract: According to some embodiments, an automated scoring analysis computer may access information in a historical data store, including sets of attribute values and prior results for a plurality of prior associations, to create a scoring model. An indication of a selected potential association from a potential association data store may be received, including a set of attribute values. The scoring analysis computer may then calculate a risk score for the selected potential association based on the scoring model. A front-end application computer server may automatically select a workflow path from a plurality of potential workflow paths.

Abstract: An aerosol provision system 1 for generating an aerosol, wherein the aerosol provision system 1 comprises a sensor 95, comprising a microphone 97, for detecting the voice of a user of the aerosol provision system 1. The aerosol provision system further comprises control circuitry 16 which is configured to receive sensor data from the sensor; determine from the sensor data whether the sensor data satisfies a predetermined criterion; and perform an operation of the aerosol provision system 1 in response to determining that the sensor data satisfies the predetermined criterion. A voice controlled or voice activated aerosol provision system 1 may thus be provided. The aerosol provision system 1 is further configured to operate in an initial or setup mode of operation, prior to performing the operation of the aerosol provision system 1, for allowing the predetermined criterion to be specified in advance.

Abstract: Various examples are provided related to low pressure delivery, e.g., less than 250 psi at the point of application, of plural component system from unpressurized parts A and B material supplies. In one example, a system includes a polyurethane spray foam (“SPF”) raw material supply including parts A and B and a fluid handling system that can deliver the SPF raw material at low pressure to a metal spray gun in metered amounts through separate material fluid paths/conduits via a heated hose length and a whip hose. The fluid handling system can also deliver air at low pressure to the spray gun through separate air stream paths so that the air is communicated to the part A and B material conduits forward of the part A and B material input locations, where they are supplied separately to a mixing nozzle that is engaged at an end of the spray gun.