Patents by Inventor Joseph R. Arron

Joseph R. Arron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isoform-selective anti-TGF? antibodies and methods of use
    Patent number: 11919948
    Abstract: The invention provides isoform-selective anti-TGF? antibodies and methods of using the same. In particular, isoform-selective anti-TGF?2, anti-TGF?3, and anti-TGF?2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGF?-related disorders.
    Type: Grant
    Filed: March 18, 2021
    Date of Patent: March 5, 2024
    Assignee: GENENTECH, INC.
    Inventors: Wei-Ching Liang, Joseph R. Arron, Daryle Depianto, Wendy Green Halpern, WeiYu Lin, Patrick J. Lupardus, Thirumalai Rajan Ramalingam, Dhaya Seshasayee, Tianhe Sun, Tulika Tyagi, Jia Wu, Yan Wu, Jian Ping Yin
  • USE OF KLK5 ANTAGONISTS FOR THE TREATMENT OF A DISEASE
    Publication number: 20230416825
    Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Sydrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.
    Type: Application
    Filed: March 29, 2023
    Publication date: December 28, 2023
    Applicant: Genentech, Inc.
    Inventors: Amy Dressen, David B. Iaea, Moulay Hicham Alaoui Ismaili, Janet K. Jackman, Robert A. Lazarus, Kelly Michele Loyet, Henry R. Maun, Brian Louis Yaspan, Tangsheng Yi, Joseph R. Arron, Hilda Y Hernandez-Barry
  • Method of treating asthma using an IL-13 antibody
    Patent number: 11226341
    Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: January 18, 2022
    Assignee: Genentech, Inc.
    Inventors: Joseph R. Arron, Richard W. Erickson, Michelle Freemer, Meredith Hazen, Guiquan Jia, John G. Matthews, Wendy Putnam, Heleen Scheerens, Yanan Zheng
  • ISOFORM-SELECTIVE ANTI-TGF-BETA ANTIBODIES AND METHODS OF USE
    Publication number: 20210301005
    Abstract: The invention provides isoform-selective anti-TGF? antibodies and methods of using the same. In particular, isoform-selective anti-TGF?2, anti-TGF?3, and anti-TGF?2/3 monoclonal antibodies are provided, e.g., for the treatment of fibrosis and other TGF?-related disorders.
    Type: Application
    Filed: March 18, 2021
    Publication date: September 30, 2021
    Applicant: Genentech, Inc.
    Inventors: Wei-Ching LIANG, Joseph R. ARRON, Daryle DEPIANTO, Wendy Green HALPERN, WeiYu LIN, Patrick J. LUPARDUS, Thirumalai Rajan RAMALINGAM, Dhaya SESHASAYEE, Tianhe SUN, Tulika TYAGI, Jia WU, Yan WU, Jian Ping YIN
  • METHODS OF DIAGNOSING AND TREATING EOSINOPHILIC DISORDERS
    Publication number: 20200165679
    Abstract: Methods of diagnosing and treating disorders related to excess eosinophil numbers or activity, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Application
    Filed: November 1, 2019
    Publication date: May 28, 2020
    Applicant: Genentech, Inc.
    Inventors: ALEXANDER R. ABBAS, JOSEPH R. ARRON, DAVID F. CHOY, GUIQUAN JIA, NICHOLAS J.I. LEWIN-KOH, KATRINA B. MORSHEAD
  • DIAGNOSIS AND TREATMENTS RELATING TO TH2 INHIBITION
    Publication number: 20190120854
    Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Application
    Filed: May 29, 2018
    Publication date: April 25, 2019
    Inventors: Joseph R. Arron, Richard W. Erickson, Michelle Freemer, Meredith Hazen, Guiquan Jia, John G. Matthews, Wendy Putnam, Heleen Scheerens, Yanan Zheng
  • USE OF KLK5 ANTAGONISTS FOR TREATMENT OF A DISEASE
    Publication number: 20190078160
    Abstract: Provided herein are methods of treating a subject, methods of predicting the response of a subject and selecting a subject suffering from a disease associated with KLK5, such as asthma or Netherton Syndrome. In particular, provided herein are uses of KLK5 antagonists for the treatment or diagnosis of asthma or Netherton Syndrome, such as an antibody or an Fc fusion polypeptide as well as pharmaceutical formulations comprising the same.
    Type: Application
    Filed: April 20, 2018
    Publication date: March 14, 2019
    Applicant: Genentech, Inc.
    Inventors: Amy Dressen, David B. Iaea, Moulay Hicham Alaoui Ismaili, Janet K. Jackman, Robert A. Lazarus, Kelly Loyet, Henry R. Maun, Brian L. Yaspan, Tangsheng Yi, Joseph R. Arron, Hilda Y. Hernandez-Barry
  • METHODS OF PROGNOSING, DIAGNOSING AND TREATING IDIOPATHIC PULMONARY FIBROSIS
    Publication number: 20190062836
    Abstract: Compositions, kits and methods for assessing the prognosis of idiopathic pulmonary fibrosis in patients are provided. In addition, compositions, kits and methods for diagnosing subtypes of idiopathic pulmonary fibrosis are provided. Also provided are methods for treating idiopathic pulmonary fibrosis.
    Type: Application
    Filed: March 16, 2018
    Publication date: February 28, 2019
    Inventors: Alexander R. ABBAS, Joseph R. ARRON, Sanjay CHANDRIANI, Guiquan JIA, Nicholas J.I. LEWIN-KOH, Daryle DEPIANTO
  • METHODS OF DIAGNOSING AND TREATING EOSINOPHILIC DISORDERS
    Publication number: 20190024178
    Abstract: Methods of diagnosing and treating disorders related to excess eosinophil numbers or activity, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Application
    Filed: October 9, 2018
    Publication date: January 24, 2019
    Applicant: Genentech, Inc.
    Inventors: ALEXANDER R. ABBAS, JOSEPH R. ARRON, DAVID F. CHOY, GUIQUAN JIA, NICHOLAS J.I. LEWIN-KOH, KATRINA B. MORSHEAD
  • Diagnosis and treatments relating to TH2 inhibition
    Patent number: 9995755
    Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: June 12, 2018
    Assignee: GENENTECH, INC.
    Inventors: Joseph R. Arron, Richard W. Erickson, Michelle Freemer, Meredith Hazen, Guiquan Jia, John G. Matthews, Wendy Putnam, Heleen Scheerens, Yanan Zheng
  • ANTI-IL-13/IL-17 BISPECIFIC ANTIBODIES AND USES THEREOF
    Publication number: 20170334985
    Abstract: The invention provides anti-IL-13/IL-17 bispecific antibodies, in particular, anti-IL13/IL17 AA, AF and FF antibodies and methods of using the same, including without limitation, methods of using the anti-IL-13/IL-17 bispecific antibodies for treating moderate to severe asthma and/or eosinophilic asthma.
    Type: Application
    Filed: February 23, 2017
    Publication date: November 23, 2017
    Applicant: Genentech, Inc.
    Inventors: LAWREN WU, JOSEPH R. ARRON, MICHAEL DILLON, DAVID F. CHOY, SUE SOHN, CHRISTOPH SPIESS, WHITNEY SHATZ
  • Diagnosis and treatments relating to TH2 inhibition
    Patent number: 9684000
    Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: June 20, 2017
    Assignee: GENENTECH, INC.
    Inventors: Joseph R. Arron, Richard W. Erickson, Michelle Freemer, Meredith Hazen, Guiquan Jia, John G. Matthews, Wendy Putnam, Heleen Scheerens, Yanan Zheng
  • METHODS OF DIAGNOSING AND TREATING EOSINOPHILIC DISORDERS
    Publication number: 20170067108
    Abstract: Methods of diagnosing and treating disorders related to excess eosinophil numbers or activity, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Application
    Filed: April 22, 2016
    Publication date: March 9, 2017
    Applicant: Genentech, Inc.
    Inventors: ALEXANDER R. ABBAS, JOSEPH R. ARRON, DAVID F. CHOY, GUIQUAN JIA, NICHOLAS J.I. LEWIN-KOH, KATRINA B. MORSHEAD
  • METHODS OF PROGNOSING, DIAGNOSING AND TREATING IDIOPATHIC PULMONARY FIBROSIS
    Publication number: 20160230226
    Abstract: Compositions, kits and methods for assessing the prognosis of idiopathic pulmonary fibrosis in patients are provided. In addition, compositions, kits and methods for diagnosing subtypes of idiopathic pulmonary fibrosis are provided. Also provided are methods for treating idiopathic pulmonary fibrosis.
    Type: Application
    Filed: September 23, 2014
    Publication date: August 11, 2016
    Applicant: GENENTECH, INC.
    Inventors: Alexander R. Abbas, Joseph R. Arron, Sanjay Chandriani, Guiquan Jia, Nicholas J.I. Lewin-Koh, Daryle DePianto
  • DIAGNOSIS AND TREATMENTS RELATING TO TH2 INHIBITION
    Publication number: 20140044645
    Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Application
    Filed: September 9, 2013
    Publication date: February 13, 2014
    Applicant: Genentech, Inc.
    Inventors: Joseph R. Arron, Richard W. Erickson, Michelle Freemer, Meredith Hazen, Guiquan Jia, John G. Matthews, Wendy Putnam, Heleen Scheerens, Yanan Zheng
  • DIAGNOSIS AND TREATMENTS RELATING TO TH2 INHIBITION
    Publication number: 20140044702
    Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Application
    Filed: September 9, 2013
    Publication date: February 13, 2014
    Applicant: Genentech, Inc.
    Inventors: Joseph R. Arron, Richard W. Erickson, Michelle Freemer, Meredith Hazen, Guiquan Jia, John G. Matthews, Wendy Putnam, Heleen Scheerens, Yanan Zheng
  • DIAGNOSIS AND TREATMENTS RELATING TO TH2 INHIBITION
    Publication number: 20120156194
    Abstract: Methods of diagnosing and treating disorders related to TH2 inhibition, including but not limited to asthma, are provided. Also provided are methods of selecting or identifying patients for treatment with certain therapeutic agents that are TH2 pathway inhibitors.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 21, 2012
    Applicant: Genentech, Inc.
    Inventors: Joseph R. Arron, Richard W. Erickson, Michelle Freemer, Meredith Hazen, Guiquan Jia, John G. Matthews, Wendy Putnam, Heleen Scheerens, Yanan Zheng
  • COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING ASTHMA
    Publication number: 20110123530
    Abstract: Compositions, kits and methods for treating and diagnosing subtypes of asthma patients are provided. Also provided are methods for identifying effective asthma therapeutic agents and predicting responsiveness to asthma therapeutic agents.
    Type: Application
    Filed: March 31, 2009
    Publication date: May 26, 2011
    Inventors: Joseph R. Arron, John V. Fahy, Barmak Modrek, Prescott Woodruff