Patents by Inventor Joseph R. HOLTMAN

Joseph R. HOLTMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating neuropathic pain
    Patent number: 10071982
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: September 11, 2018
    Assignees: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R Holtman, Peter Anthony Crooks, Linda P Dwoskin, J Michael McIntosh, Elzbieta Pogonowska Wala
  • METHOD OF TREATING NEUROPATHIC PAIN
    Publication number: 20160340335
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 6, 2013
    Publication date: November 24, 2016
    Applicants: University of Utah, University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter Anthony CROOKS, Linda P. DWOSKIN, J. Michael MCINTOSH, Elzbieta Pogonowska WALA
  • Bis-quaternary ammonium salts as pain modulating agents
    Patent number: 9499518
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: November 22, 2016
    Assignees: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R. Holtman, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
    Publication number: 20160279119
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 13, 2010
    Publication date: September 29, 2016
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • Use of -quaternary ammonium salts as pain modulating agents
    Patent number: 9155733
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nociception and pain.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: October 13, 2015
    Assignees: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R. Holtman, Peter Anthony Crooks, Linda P. Dwoskin, J. Michael McIntosh
  • Opioid-nornicotine codrugs combinations for pain management
    Patent number: 8710069
    Abstract: The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic analgesic response to pain.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: April 29, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Joseph R. Holtman, Peter A. Crooks, Ujjwal Chakraborty
  • Opioid-ketamine and norketamine codrug combinations for pain management
    Patent number: 8710070
    Abstract: The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and ketamine or norketamine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic analgesic response to pain.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: April 29, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Joseph R. Holtman, Peter A. Crooks, Ujjwal Chakraborty
  • METHOD OF TREATING NEUROPATHIC PAIN
    Publication number: 20140011836
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 9, 2014
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter Anthony CROOKS, Linda P. DWOSKIN, J. Michael MCINTOSH, Elzbieta Pogonowska WALA
  • BIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
    Publication number: 20110166177
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 13, 2010
    Publication date: July 7, 2011
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • Opioid-Nornicotine Codrugs Combinations for Pain Management
    Publication number: 20110112130
    Abstract: The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic analgesic response to pain.
    Type: Application
    Filed: March 27, 2009
    Publication date: May 12, 2011
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. Holtman, Peter A. Crooks, Ujjwal Chakraborty
  • Opioid-Ketamine and Norketamine Codrug Combinations for Pain Management
    Publication number: 20110112131
    Abstract: The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and ketamine or norketamine which have been combined to form a single chemical codrug entity. When the codrug is administered it produces a synergistic analgesic response to pain.
    Type: Application
    Filed: March 27, 2009
    Publication date: May 12, 2011
    Applicant: University of Kentucky Research Foundation A144 ASTeCC Building
    Inventors: Joseph R. Holtman, Peter A. Crooks, Ujjwal Chakraborty
  • NORNICOTINE FOR THE TREATMENT OF PAIN
    Publication number: 20100216847
    Abstract: This invention relates to the use of R(+)-, S(?)- or racemic nornicotine for the treatment of pain.
    Type: Application
    Filed: November 16, 2007
    Publication date: August 26, 2010
    Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joseph R. Holtman, JR., Peter A. Crooks, Linda Dwoskin, Elzbieta P. Wala
  • USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
    Publication number: 20100173937
    Abstract: Provided are methods of modulating, treating, reversing and/or preventing pain using tetrakis quaternary ammonium compounds, especially regarding pain of central and/or peripheral origin and/or pain which is nociceptive, neuropathic, somatic, visceral, and/or inflammatory in nature.
    Type: Application
    Filed: December 7, 2009
    Publication date: July 8, 2010
    Applicants: University of Kentucky Research Foundation, University of Utah
    Inventors: Joseph R. HOLTMAN, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh
  • USE OF TRIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS
    Publication number: 20100120857
    Abstract: Provided are tris-quaternary ammonium compounds which are modulators of nociception and pain.
    Type: Application
    Filed: October 9, 2009
    Publication date: May 13, 2010
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter A. CROOKS, Linda P. DWOSKIN, J. Michael MCINTOSH
  • SYNERGISTIC EFFECTS OF COMBINATIONS OF NORNICOTINE AND OPIOIDS FOR THE TREATMENT OF PAIN
    Publication number: 20100048605
    Abstract: This invention relates to pharmaceutical compositions and methods where S(?)-nornicotine, R(+)-nornicotine, or racemic nornicotine are co-administered with an opioid analgesic in amounts effective to cause or enhance a synergistic analgesic response to treat pain (including acute, chronic, and cancer related pain). Preferably the coadministration of nornicotine with the opioid results in decreased dependence and tolerance potential as well as diminishing side effects, compared to conventional opioid therapy.
    Type: Application
    Filed: December 11, 2007
    Publication date: February 25, 2010
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. Holtman, JR., Peter A. Crooks
  • Novel synergistic opioid-cannabinoid codrug for pain management
    Publication number: 20080176885
    Abstract: Compounds including an opioid, and a cannabinoid covalently bound by a linker; pharmaceutical formulations including codrugs; methods of manufacture as well as methods of treatment are disclosed.
    Type: Application
    Filed: October 10, 2007
    Publication date: July 24, 2008
    Applicant: University of Kentucky
    Inventors: Joseph R. Holtman, Peter A. Crooks, Harpreet K. Dhooper
  • SYNERGISTIC COMBINATIONS OF NORKETAMINE AND OPIOID ANALGESICS
    Publication number: 20080132531
    Abstract: The present invention relates to methods of alleviating pain with the administration of norketamine with a narcotic. More particularly, the invention provides a method of alleviating pain through the administration of a dose of norketamine, which, if administered alone would provide sub-optimal analgesic relief, yet provides analgesic relief when combined with a narcotic. In some embodiments, the combination of norketamine with a narcotic, further allows for the administration of a dose narcotic, which would be sub-optimal if used alone, but provides adequate pain relief in combination with norketamine. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine/opioid compositions effective to alleviate pain to a subject suffering from pain.
    Type: Application
    Filed: November 10, 2006
    Publication date: June 5, 2008
    Inventors: Joseph R. Holtman, Peter A. Crooks