Patents by Inventor Joseph R. Lennox

Joseph R. Lennox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
    Patent number: 8883758
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: November 11, 2014
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Gregory J. Haley, Joseph R. Lennox, Alan Xin Xiang, Erik J. Rueden
  • 3,5-Disubstituted and 3,5,7-Trisubstituted-3H-Oxazolo and 3H-Thiazolo[4,5-d]pyrimidin-2-one Compounds and Prodrugs Thereof
    Publication number: 20130259831
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Application
    Filed: May 22, 2013
    Publication date: October 3, 2013
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Gregory J. Haley, Joseph R. Lennox, Alan Xin Xiang, Erik J. Rueden
  • 3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO[4,5-D]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
    Publication number: 20120121541
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Application
    Filed: January 13, 2012
    Publication date: May 17, 2012
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Gregory J. Haley, Joseph R. Lennox, Alan X. Xiang, Erik J. Rueden
  • 3,5-disubstituted and 3,5,7-trisubstituted-3-oxazolo and 3-thiazolo[4,5-]pyrimidin-2-one compounds and prodrugs thereof
    Patent number: 8097718
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: January 17, 2012
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Gregory J. Haley, Joseph R. Lennox, Alan X. Xiang, Erik J. Rueden
  • 3,5-DISUBSTITUTED AND 3,5,7-TRISUBSTITUTED-3H-OXAZOLO AND 3H-THIAZOLO[4,5-d]PYRIMIDIN-2-ONE COMPOUNDS AND PRODRUGS THEREOF
    Publication number: 20110275589
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Application
    Filed: July 1, 2009
    Publication date: November 10, 2011
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Gregory J. Haley, Joseph R. Lennox, Alan X. Xiang, Erik J. Rueden
  • 3-?-D-ribofuranosylthiazolo[4-5-d]pyrimidine nucleosides and uses thereof
    Patent number: 7943759
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: May 17, 2011
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden, David Louis Clark, Alan Xin Xiang
  • 3-ß-D-RIBOFURANOSYLTHIAZOLO[4-5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF
    Publication number: 20100261667
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: June 25, 2010
    Publication date: October 14, 2010
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden, David Louis Clark, Alan X. Xiang
  • 3-?-D-ribofuranosylthiazolo[4,5-]pyrimidine nucleosides and uses thereof
    Patent number: 7745415
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Grant
    Filed: January 17, 2008
    Date of Patent: June 29, 2010
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden
  • Prodrugs of 5-amino-3-(3?-deoxy-?-D-ribofuranosyl)-thiazolo[4,5-]pyrimidin-2,7-dione
    Patent number: 7709448
    Abstract: The invention is directed to 5-amino-3-(3?-deoxy-?-D-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione prodrugs, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: May 4, 2010
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Gregory J. Haley, Joseph R. Lennox, Alan X. Xiang, Stephen E. Webber
  • 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
    Patent number: 7560544
    Abstract: The invention is directed to 3,5-disubstituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions containing them, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds and prodrugs.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: July 14, 2009
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Stephen E. Webber, Gregory J. Haley, Joseph R. Lennox, Alan X. Xiang, Erik J. Rueden
  • Carbonate and carbamate prodrugs of thiazolo[4,5-]pyrimidines
    Patent number: 7528115
    Abstract: The invention is directed to carbonate and carbamate prodrugs of thiazolo[4,5-d]pyrimidine compounds, whose metabolized parent compound has immunomodulatory activity. The invention also relates to the therapeutic use of such prodrugs and pharmaceutical compositions thereof in treating disease states associated with abnormal cell growth, such as cancer.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: May 5, 2009
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Gregory J. Haley, Joseph R. Lennox, Alan X. Xiang, Stephen E. Webber
  • 3-B-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIMIDINE NUCLEOSIDES AND USES THEREOF
    Publication number: 20080255063
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: January 17, 2008
    Publication date: October 16, 2008
    Applicant: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averet, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden, David Louis Clark, Alan X. Xiang
  • 3-Beta-D-Ribofuranosylthiazolo[ 4,5-D] Pyridimine Nucleosides and Uses Thereof
    Publication number: 20080070852
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyrimidine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: June 7, 2004
    Publication date: March 20, 2008
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden, David Louis Clark, Alan X. Xiang
  • 3-B-D-ribofuranosylthiazolo [4,5-] pyrimidine nucleosides and uses thereof
    Patent number: 7321033
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: January 22, 2008
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden, David Louis Clark, Alan Xin Xiang
  • 1,3-disubstituted-2-thioxo-imidazolidine-4,5-diones as potassium channel openers
    Patent number: 7115620
    Abstract: Compounds of Formula I are provided: wherein: R is lower alkyl or branched lower alkyl; and Ar is phenyl, phenyl substituted with one or more of halogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylamino, cyano, or perfluoroalkoxy, or a heteroaromatic moiety; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: October 3, 2006
    Assignee: Wyeth
    Inventors: John A Butera, Hassan M Elokdah, Theodore S Sulkowski, John L Primeau, Joseph R Lennox, Russell F Graceffa
  • 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
    Patent number: 7008636
    Abstract: This invention provides compounds of Formula I having the structure or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: March 7, 2006
    Assignee: Wyeth
    Inventors: John A. Butera, Craig E. Caufield, Russell F. Graceffa, Alexander Greenfield, Eric G. Gundersen, Lisa Marie Havran, Alan H. Katz, Joseph R. Lennox, Scott C. Mayer, Robert E. McDevitt
  • 3-?-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof
    Patent number: 6924271
    Abstract: The invention is directed to 3-?-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: August 2, 2005
    Assignee: Anadys Pharmaceuticals, Inc.
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden
  • 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
    Publication number: 20040214869
    Abstract: This invention provides compounds of Formula I having the structure 1
    Type: Application
    Filed: May 11, 2004
    Publication date: October 28, 2004
    Applicant: Wyeth
    Inventors: John A. Butera, Craig E. Caufield, Russell F. Graceffa, Alexander Greenfield, Eric G. Gundersen, Lisa Marie Havran, Alan H. Katz, Joseph R. Lennox, Scott C. Mayer, Robert E. McDevitt
  • 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
    Patent number: 6765021
    Abstract: This invention provides compounds of formula I having the structure wherein: B, D, C, and R1 as defined herein.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: July 20, 2004
    Assignee: Wyeth
    Inventors: John A. Butera, Craig E. Caufield, Russell F. Graceffa, Alexander Greenfield, Eric G. Gundersen, Lisa Marie Havran, Alan H. Katz, Joseph R. Lennox, Scott C. Mayer, Robert E. McDevitt
  • 3-beta-D-ribofuranosylthiazolo[4-5-d]pyridimine nucleosides and uses thereof
    Publication number: 20030199461
    Abstract: The invention is directed to 3-&bgr;-D-ribofuranosylthiazolo[4,5-d]pyridimine nucleosides and pharmaceutical compositions containing such compounds that have immunomodulatory activity. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
    Type: Application
    Filed: November 27, 2002
    Publication date: October 23, 2003
    Inventors: Devron R. Averett, Stephen E. Webber, Joseph R. Lennox, Erik J. Rueden