Abstract: An electronic tracking tag that attaches a battery to the tag's circuitry by folding over a portion of the flexible PCB on top of the battery to secure it between two conductive pads. This configuration eliminates the need for a battery holder, thereby reducing weight, cost, and thickness and enabling a label containing the electronics to be fed through a printer without damaging the circuit. The battery may be attached to conductive pads using a conductive adhesive such as a conductive tape, avoiding the use of rigid or brittle tabs or epoxies that may break under the stress of going through the printer. An illustrative configuration with the electronic components, the battery, the fold-over battery attachment, and a label front and liner backing may be less than 2100 micrometers thick.

Abstract: An item tracking system that uses smart tracking labels to track an item's position, and that switches between short-range tracking within a local area using short-range interfaces like Bluetooth and long-range tracking within a global or regional area using long-range interfaces like GPS. Long-range communication interfaces may be disabled when the tracking label comes within range of a short-range network such as a Bluetooth network within a warehouse. Switching to short-range services when they are available may significantly reduce the total power requirement for a tracking label. In an illustrative embodiment a tracking label may periodically broadcast an advertising message over Bluetooth; when a Bluetooth gateway in a warehouse or other local area responds to this message, the label disables long-range interfaces and switches position tracking to use short-range services. When the label loses communication with a short-range network, it re-enables the long-range interfaces.

Abstract: A process for activating tracking labels of an item tracking system that uses a printer to activate labels as they are printed for use. Electronic tracking labels may have a removable portion that breaks an electrical circuit when removed; breaking the circuit activates the label. A printer with a label cutter may be used when labels are prepared for use, and the printer may be configured to cut off the removable portion of the label during label printing. This method automates label activation as part of the label preparation process. The printer may be programmed to position the boundary between the removable portion of the label and the rest of the label under the cutter, for example using knowledge of the label's layout. A printed, activated label output from the printer may be placed directly on an item to be tracked.

Abstract: A routing system that can receive, decode, and route messages from electronic tracking tags made by different manufacturers and issued by different tag issuers. Tracking tags may be placed on items that are shipped or stored, and wireless messages from the tags may be used to track the items and their status. The system enables a site to use a single gateway that obtain messages from heterogeneous tracking tags; the gateway forwards messages to the routing system for processing. The system may access a tag manufacturers database that contains a descriptor of the messages from each manufacturer's tags, and a tag registrations database that lists tags associated with each tag issuer. The system supports tag messages with encrypted contents and with tag identifiers that are rotated to prevent malicious tracking, and it may check message integrity to detect modification of the message after it is sent from the tag.

Abstract: A hierarchical aggregation tracking and monitoring system using “smart” tracking labels on packages and on the items contained in the packages. The labels may have printed information on the top and electronics and sensors embedded in thin, flexible layers underneath. Multiple levels of packaging may be tracked, such as boxes aggregated into pallets, which are in turn aggregated into larger containers. Smart labels on packages may communicate with smart labels on the contained items to retrieve item-level sensor data and forward this data to a central server. By using the package labels as gateways, item labels may be made simpler and less expensive. Package labels may detect when an item label does not respond and may notify a server that an item may be missing. Sensors and communications interfaces on labels may be used to automate generation and confirmation of containment data that indicates which items are in which packages.

Abstract: A tracking and monitoring system that uses “smart” tracking labels with printed label information on the top and electronics and sensors embedded in thin, flexible layers underneath. Labels may be used to track the location of items, and to monitor item parameters such as temperature, shock, weight, or tampering. Tracking labels may have communications interfaces to transmit label location and sensor data to a centralized server for monitoring and analysis; interfaces may include for example Bluetooth, Wi-Fi, cellular, or Amazon Sidewalk. Label location may be determined from an integrated GPS, by triangulation using received signals from cellular or other networks, or from the location of nearby connected devices. Labels may be battery powered and may use energy harvesting to obtain power from the environment. To conserve battery life, manufactured labels may be put into a hibernation state, and activated when they are placed on an item.

Abstract: Handoff of (i) a mobile wirelessly communicating device—a mobile—between (ii) as plurality of stationary base stations within cells within a domain of (iii) a stationary gateway router all within (iv) a communications network based on the Internet Protocol (IP) is without interchange of control and responsive to the mobile, only. The gateway router assigns to the mobile at a time before the handoff IP addresses suitable for the mobile to connect to the gateway router through all the plurality of base stations of the domain. Unilaterally deriving a handoff decision to switch base stations, the mobile directs its wireless communications link to a new base station where signal level registration is performed. Responsive to a link layer trigger at the new base station, the gateway router is informed of the handoff, and both the router and the mobile independently construct the mobile's new IP address.

Abstract: The invention describes a vitamin receptor binding drug delivery conjugate, and preparations therefor. The drug delivery conjugate consists of a vitamin receptor binding moiety, a bivalent linker (L), and a drug. The vitamin receptor binding moiety includes vitamins, and vitamin receptor binding analogs and derivatives thereof, and the drug includes analogs and derivatives thereof. The vitamin receptor binding moiety is covalently linked to the bivalent linker, and the drug, or the analog or the derivative thereof, is covalently linked to the bivalent linker, wherein the bivalent linker (L) includes components such as spacer linkers, releasable linkers, and heteroatom linkers, and combinations thereof. Methods and pharmaceutical compositions for eliminating pathogenic cell populations using the drug delivery conjugate are also described.