Abstract: Self-sealing closure structures are provided for a pouch having first and second webs secured together partially around an interior portion. Each web has at least one generally straight end edge that defines a portion of the pouch opening and that is in registry with the end edge of the other web. An adhesive sealing strip is disposed on the first web parallel with and near the first web one end edge. Folding of the webs together about two or more fold lines orients the adhesive sealing strip against an adjacent region of the second web to form a closure seal in the pouch. A pharmacy fold may be provided in some of the closures.