Patents by Inventor Joseph Reginald Osborne

Joseph Reginald Osborne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and methods for determining optimum patient-specific antibody dose for tumor targeting
    Patent number: 10806808
    Abstract: The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: October 20, 2020
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Pat B. Zanzonico, Sarah M. Cheal, Steven M. Larson, Joseph Reginald Osborne, Edward Komin Fung, David Ulmert
  • SYSTEMS AND METHODS FOR DETERMINING OPTIMUM PATIENT-SPECIFIC ANTIBODY DOSE FOR TUMOR TARGETING
    Publication number: 20180133350
    Abstract: The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.
    Type: Application
    Filed: May 19, 2016
    Publication date: May 17, 2018
    Inventors: Pat B. Zanzonico, Sarah M. Cheal, Steven M. Larson, Joseph Reginald Osborne, Edward Komin Fung, David Ulmert