Abstract: The present invention relates to a shaping tool (10B) for keratin fibers comprising a gripping member (12) and a shaping member (14) comprising a base body (18) and ribs (20). The base body (18) is integral with the gripping member (12), and has two lateral edges (24) and a free distal edge (26) opposite the gripping member (12). Each rib (20) protruding from the base body (18), the ribs (20) also extending parallel to one another and to a transverse axis (Y) and defining grooves (22) between them, each rib (20) having a constant height along the transverse axis (Y) between the two lateral edges (24), the free distal edge (26) of the base body (18) extending parallel to the transverse axis (Y).

Abstract: A device for picking up and applying a cosmetic composition, in particular makeup, having a flexible support defining an, in particular continuous, application surface intended to receive the cosmetic composition, and at least two elements that are movable with respect to one another and are connected to the support, such that a relative movement of these two elements brings about a mechanical stress on the support and causes the latter to deform between a configuration for picking up cosmetic composition and an application configuration.

Abstract: An applicator for applying at least one fibre to human keratin materials, and in particular for filling out and/or lengthening the eyelashes or eyebrows. The applicator includes at least one channel into which a fibre is inserted, and this channel is defined by at least one portion that, in section, entirely surrounds the fibre and has at least one end-of-travel stop that limits the insertion of the fibre.

Abstract: Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first arm and second arm, wherein the first arm is linked to a first ligand that includes a first saccharide and the second arm is linked to a second ligand that includes a second saccharide and wherein the first saccharide is fucose. The formulation is suitable for subcutaneous administration and provides a basal pharmacodynamic profile for the insulin oligosaccharide conjugate.

Abstract: Disclosed is a pharmaceutical formulation comprising an insulin or insulin analog molecule covalently attached to at least one branched linker having a first arm and second arm, wherein the first arm is linked to a first ligand that includes a first saccharide and the second arm is linked to a second ligand that includes a second saccharide and wherein the first saccharide is fucose suitable for parenteral or subcutaneous administration and which is suitable for use in controlling post-prandial glucose levels in an individual.

Abstract: A new and useful device for assisting and training the hyperextension of plantar flexion of the ankle which can be operated by a single user, is easy to use, allows for variable adjustment of the angle of plantar flexion, is handheld, and can be used in a variety of applications and physical disciplines. This device is believed to be useful in the athletic and physical arts disciplines such as ballet. The device comprises a handle that is rotationally connected to a plantar attachment by way of a central axis rod. When connected together, the plantar attachment rotates around the central axis rod, thereby creating angles relative to the handle. The device can be locked into a desired angle by the insertion of a locking pin prior to use. The user places her foot on the sole portion of the plantar attachment, fixes an attaching means around her foot, and places her heel into a calcaneal well on the handle.

Abstract: A support system for the mounting/suspension/elevation of a commercial projector is disclosed. The projector support grasps the projector to be mounted at one of its surfaces (typically, the bottom surface) through the use of two support arms. The support arms are affixed to the projector surface though mounting screws or other equivalent fastening mechanisms. The support arms each feature an adjustment slot which runs substantially the entire length of the arms. The presence of the two slotted arms allows for a countless array of scissoring arrangements for the support arms. This allows for interconnection with/mounting of the vast majority of commercial projectors (which invariably feature differing constellations of mounting holes). The projector support also employs a primary mount to facilitate swiveling/positioning of the projector so that the unit is effectually oriented for projection.

Abstract: Circuitry for and method of power efficient operation of, and energy recovery from, tissue-stimulating electrodes having high charge capacities. Post-stimulation energy is recovered from the electrodes through a variety of techniques into circuit elements such as other electrodes, an intermediate distribution system, a power supply or any other elements, through the use of sequential switching. Energy is also recoverable from the intermediate distribution system, which preferably is comprised of one or more storage capacitors operating a different voltages. Efficient power transfer among circuit elements is effected by transferring energy while limiting element-element voltage differences and/or voltage differences between the elements and the capacitances of the electrodes.

Abstract: A system and method are provided for generating, maintaining and rendering landing pages. The system may include a user interface configured to allow input of an identification of a plurality of fields and rendering criteria. A template defines a look and feel of a web page. A landing page generating facility is configured to receive an identification of a plurality of fields and rendering criteria from the user interface and to generate a landing page based on the template and the rendering criteria. The landing page includes the plurality of fields.

Abstract: Circuitry for and method of power efficient operation of, and energy recovery from, tissue-stimulating electrodes having high charge capacities. Post-stimulation energy is recovered from the electrodes through a variety of techniques into circuit elements such as other electrodes, an intermediate distribution system, a power supply or any other elements, through the use of sequential switching. Energy is also recoverable from the intermediate distribution system, which preferably is comprised of one or more storage capacitors operating a different voltages. Efficient power transfer among circuit elements is effected by transferring energy while limiting element-element voltage differences and/or voltage differences between the elements and the capacitances of the electrodes.

Abstract: Neural prosthesis for implantation within an eye. The prosthesis includes a foldable substrate and at least one electronic component supported by the substrate. At least one microchannel is disposed within the substrate. Upon inflation, the foldable substrate will unfold to provide for close contact of the electronic component with neural tissue, thus facilitating surgical implantation through a narrow incision, yet allowing the unfolded device to cover a sufficiently large portion of the patient's retina to provide useful vision.

Abstract: A combination of silicon processing technology advances and increased understanding of the mechanisms underlying phosphene generation in human retinas by surface electrical stimulation has now made it possible to conceive of a chronically implantable retinal prosthesis for the blind which will restore some useful vision to patients over at least several degrees of their former field of view. These thin, strong, and flexible epiretinal devices are constructed of or encapsulated in known biocompatible materials which will have a long working life in the eye's saline environment. The function of the implants is to electrically stimulate the ganglion cell layer at the surface of the retina using controlled current sources. Due to the exceptionally low mass of the implant and its flexible, nearly planar form, patient discomfort and fluid drag caused by the implant minimized.

Abstract: Dynamically functional intra-ocular prosthesis. The prosthesis includes an implantable intra-ocular lens and microelectronic components mounted on the lens. One embodiment is a variable focal length implantable intra-ocular lens system for adjusting the focal length of the implantable lens. In one embodiment, a micromotor changes the tension in a band encircling the peripheral portion of the deformable lens changing its shape to vary its focal length. Another embodiment is an artificial intra-ocular lens which serves as a holding substrate for microelectronic components that form part of a prosthesis to stimulate the neural elements of the eye to restore vision to patients who are blind from retinal disease.

Abstract: Dynamically functional intra-ocular prosthesis. The prosthesis includes an implantable intra-ocular lens and microelectronic components mounted on the lens. One embodiment is a variable focal length implantable intra-ocular lens system for adjusting the focal length of the implantable lens. In one embodiment, a micromotor changes the tension in a band encircling the peripheral portion of the deformable lens changing its shape to vary its focal length. Another embodiment is an artificial intra-ocular lens which serves as a holding substrate for microelectronic components that form part of a prosthesis to stimulate the neural elements of the eye to restore vision to patients who are blind from retinal disease.

Abstract: A method for epi-retinal implantation of an object into a subject is disclosed. The method includes rendering the normally transparent cortical vitreous visible and separating at least a portion of a cortical vitreous of the subject away from an adherent retinal surface to form an epi-retinal space between the retina and the separated cortical vitreous material. An object to be implanted may be introduced into the epi-retinal space and the object engaged with a surface of the retina. In preferred embodiments, the object may then be adhered to the surface of the retina. A method for implantation of a neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated is also described.

Abstract: A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.

Abstract: Medication dispensing intra-ocular lens system for implantation into an eye. An implantable intra-ocular lens includes a carrier medium disposed on a surface of the lens. A biologically active material is embedded in the carrier medium for controlled release into the eye. Contemplated biologically active materials include antibiotics, anti-inflammatory agents and cell growth inhibitors. The controlled release of biologically active materials within the eye is more effective than conventional topical applications of the same substances.

Abstract: A low-pressure neural contact structure for contact with neural tissue, for example, neural tissue of the retina within which are ganglion cells to be electrically stimulated. The contact structure comprises a first portion for attachment to a first bodily location, such as the inner surface of the retina, and a second portion interconnected with the first portion via an interconnection and being held in contact with the neural tissue. The interconnection exhibits a weak restoring force which in conjunction with the geometry of said second portion provides a preselected desired pressure of contact against the neural tissue. As adapted for the retina, the interconnection exhibits a weak restoring force developed in response to curvature of the interconnection along the inner radius of the retina.

Abstract: The invention provides a method for preferentially stimulating neural somas over neural axons located around the somas but not integral with the somas. In the invention, a positive electrical pulse is applied to a region of neural tissue consisting of one or more neural somas to be stimulated and neural axons, and due to the physiology of the somas, they are preferentially stimulated by the electrical pulse over the neural axons not integral with the somas to be stimulated. The preferential soma stimulation provided by the invention achieves the advantage of locally focusing external stimulation such that it may be directed to particular soma locations for indicating location-dependent sensory information. Thus the pulse scheme of the invention may be employed in prosthetic applications directed to, for example, the retinal ganglia neural tissue.

Abstract: A lottery ticket scraper has a body and a resilient scraper element supported in cantilever position on the body. The body and scraper element cooperate to define a ticket receiving slot through which a ticket may pass. A scraping edge on the scraper element and disposed within the slot is movable into scraping engagement with the surface of a lottery ticket inserted into the slot in response to squeezing pressure applied to the body and the scraper element so that a removable coating may be scraped from the surface of the ticket by pulling the ticket through the ticket scraper.