Abstract: An airway management isolation enclosure and a method for protecting medical personnel from infectious agents when treating a patient having an infectious disease, comprising: (a) a frame that is positioned over the head and anterior thoracic region of the patient; (b) a transparent barrier supported by frame, which covers and forms a seal around the head and anterior thoracic region of the patient and allows medical personnel to create sealable entry ports; and (c) an air flow entry and a vacuum exit connection to direct the infectious agents in the form of respiratory droplets and particles produced by the patient to flow away from the head of the patient and out of the transparent covering while the medical personnel manages the airway and upper aerodigestive tract of the patient.