Patents by Inventor Joseph S. Podolski

Joseph S. Podolski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10328022
    Abstract: The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active agents. Embodiments of the instant invention disclose methods for treating a variety of progesterone related disorders by vaginal administration of a pullulan capsule comprising one or more antiprogestins.
    Type: Grant
    Filed: May 30, 2013
    Date of Patent: June 25, 2019
    Assignee: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. Podolski, Kuang Hsu
  • Publication number: 20190127413
    Abstract: The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. New compounds and methods for treating these conditions are disclosed. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.
    Type: Application
    Filed: May 14, 2018
    Publication date: May 2, 2019
    Inventors: Joseph S. Podolski, Ronald D. Wiehle
  • Publication number: 20190008804
    Abstract: The present invention pertains to a combination for simultaneous, separate, or sequential use which comprises (a) trans-clomiphene or a salt or analogue thereof and (b) a progesterone receptor antagonist and to its use for the treatment of hormone-dependent conditions.
    Type: Application
    Filed: January 11, 2017
    Publication date: January 10, 2019
    Inventors: Joseph S. Podolski, Greg Fontenot
  • Publication number: 20180325810
    Abstract: The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active agents. Embodiments of the instant invention disclose methods for treating a variety of progesterone related disorders by vaginal administration of a pullulan capsule and a fill formulation comprising one or more antiprogestins dispersed in a mixture of isopropyl palmitate or isopropyl myristate and a polyethylene glycol.
    Type: Application
    Filed: July 20, 2018
    Publication date: November 15, 2018
    Inventors: Joseph S. Podolski, Kuang Hsu
  • Patent number: 10064815
    Abstract: The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active agents. Embodiments of the instant invention disclose methods for treating a variety of progesterone related disorders by vaginal administration of a pullulan capsule and a fill formulation comprising one or more antiprogestins dispersed in a mixture of isopropyl palmitate or isopropyl myristate and a polyethylene glycol.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: September 4, 2018
    Inventors: Joseph S. Podolski, Kuang Hsu
  • Patent number: 9981906
    Abstract: The present invention relates to substantially pure metabolites of irara-clomiphene. The invention is also directed to pharmaceutical compositions comprising these metabolites and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: May 29, 2018
    Assignee: Repros Therapeutics Inc.
    Inventors: Joseph S. Podolski, Ronald D. Wiehle
  • Patent number: 9914696
    Abstract: The present invention provides a one-pot method for synthesizing clomiphene (a mixture of the isomers cis-clomiphene and trans-clomiphene) utilizing a single solvent. In a preferred embodiment, the single solvent is dichloromethane (DCM, also known as methylene chloride). The present invention provides an improved method for synthesizing clomiphene and purifying clomiphene isomers.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: March 13, 2018
    Assignee: Repros Therapeutics Inc.
    Inventors: Joseph S. Podolski, Kuang Hsu
  • Publication number: 20170189421
    Abstract: The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (SERM) therapy. The instant invention is also relevant to the suppression of endometrial proliferation. The instant invention is also relevant to the treatment of pain associated with endometriosis. The compositions for practicing the methods, comprising progesterone antagonists are also disclosed. Embodiments of the instant invention also disclose methods for identifying new selective progesterone receptor modulators for practicing disclosed methods of treatment.
    Type: Application
    Filed: March 21, 2017
    Publication date: July 6, 2017
    Applicant: REPROS THERAPEUTICS INC.
    Inventor: Joseph S. Podolski
  • Publication number: 20170181965
    Abstract: The subject matter of the present invention is pertinent to the field of vaginal delivery of pharmaceutically active agents. Embodiments of the instant invention disclose methods for treating a variety of progesterone related disorders by vaginal administration of a pullulan capsule and a fill formulation comprising one or more antiprogestins dispersed in a mixture of isopropyl palmitate or isopropyl myristate and a polyethylene glycol.
    Type: Application
    Filed: April 22, 2015
    Publication date: June 29, 2017
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. PODOLSKI, Kuang HSU
  • Patent number: 9687458
    Abstract: The present invention relates to the administration of compositions comprising an antiestrogen, preferably a selective estrogen receptor modulator (SERM) such as trans-clomiphene, for treating cancer and associated diseases. The invention is also directed to methods for reducing IGF-1 levels in a subject in need thereof by administering a composition comprising an antiestrogen, preferably a SERM such as trans-clomiphene.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: June 27, 2017
    Assignee: Repros Therapeutics Inc.
    Inventors: Joseph S. Podolski, Ronald D. Wiehle, Kuang Hsu, Greg Fontenot
  • Patent number: 9616034
    Abstract: The present invention relates to the administration of compositions comprising trans-clomiphene or an analog or salt thereof, for inhibiting bone resorption and bone turnover in a subject. The invention is also directed to methods for increasing bone mineral density in a subject and preventing or treating a bone related disorder in a subject comprising administering to the subject an effective amount of trans-clomiphene or an analog or salt thereof.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: April 11, 2017
    Assignee: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. Podolski, Kuang Hsu, Ronald D. Wiehle, Greg Fontenot, Jaye Thompson
  • Patent number: 9616074
    Abstract: The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (SERM) therapy. The instant invention is also relevant to the suppression of endometrial proliferation. The instant invention is also relevant to the treatment of pain associated with endometriosis. The compositions for practicing the methods, comprising progesterone antagonists are also disclosed. Embodiments of the instant invention also disclose methods for identifying new selective progesterone receptor modulators for practicing disclosed methods of treatment.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: April 11, 2017
    Assignee: REPROS THERAPEUTICS INC.
    Inventor: Joseph S. Podolski
  • Publication number: 20170073302
    Abstract: The present invention provides a one-pot method for synthesizing clomiphene (a mixture of the isomers cis-clomiphene and trans-clomiphene) utilizing a single solvent. In a preferred embodiment, the single solvent is dichloromethane (DCM, also known as methylene chloride). The present invention provides an improved method for synthesizing clomiphene and purifying clomiphene isomers.
    Type: Application
    Filed: March 9, 2015
    Publication date: March 16, 2017
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. PODOLSKI, Kuang HSU
  • Patent number: 9545411
    Abstract: The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. Methods for treating these conditions are provided comprising systemically administering an antiprogestin and contemporaneously locally administering an antiprogestin. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: January 17, 2017
    Assignee: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. Podolski, Ronald D. Wiehle
  • Publication number: 20160354325
    Abstract: The present invention relates to the use of compositions comprising trans-clomiphene for treating men with hypogonadism. The invention is also directed to methods for treating males with hypogonadism.
    Type: Application
    Filed: August 17, 2016
    Publication date: December 8, 2016
    Applicant: REPROS THERAPEUTICS INC.
    Inventor: Joseph S. PODOLSKI
  • Publication number: 20160346295
    Abstract: The present invention relates to the long-term administration of a selective estrogen receptor modulator (SERM) with a short half-life for the treatment of a variety of estrogen receptor-mediated conditions. The SERM may be administered at a concentration at or below that of a SERM with a long half-life in order to achieve an equivalent therapeutic effect.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 1, 2016
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. PODOLSKI, Ronald D. WIEHLE
  • Publication number: 20160128953
    Abstract: The present invention relates to the administration of compositions comprising trans-clomiphene or an analogue or salt thereof, for inhibiting bone resorption and bone turnover in a subject. The invention is also directed to methods for increasing bone mineral density in a subject and preventing or treating a bone related disorder in a subject comprising administering to the subject an effective amount of trans-clomiphene or an analogue or salt thereof.
    Type: Application
    Filed: June 3, 2014
    Publication date: May 12, 2016
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. PODOLSKI, Kuang HSU, Ronald D. WIEHLE, Greg FONTENOT, Jaye THOMPSON
  • Patent number: 9283234
    Abstract: The subject matter of the instant invention is pertinent to the field of hormone therapy. More specifically, the subject matter of the instant invention concerns methods of treating estrogen-dependent conditions such as endometrial hyperplasia and endometrial cancer in a female undergoing estrogen and/or selective estrogen receptor modulator (SERM) therapy. The instant invention is also relevant to the suppression of endometrial proliferation. The instant invention is also relevant to the treatment of pain associated with endometriosis. The compositions for practicing the methods, comprising progesterone antagonists are also disclosed. Embodiments of the instant invention also disclose methods for identifying new selective progesterone receptor modulators for practicing disclosed methods of treatment.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: March 15, 2016
    Assignee: REPROS THERAPEUTICS INC.
    Inventor: Joseph S. Podolski
  • Publication number: 20160038506
    Abstract: The present invention relates to the long-term administration of a selective estrogen receptor modulator (SERM) with a short half-life for the treatment of a variety of estrogen receptor-mediated conditions. The SERM may be administered at a concentration at or below that of a SERM with a long half-life in order to achieve an equivalent therapeutic effect.
    Type: Application
    Filed: October 19, 2015
    Publication date: February 11, 2016
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. Podolski, Ronald D. Wiehle
  • Publication number: 20150297612
    Abstract: The subject matter of the instant invention is pertinent to the field of treatment of hormone-dependent conditions. Methods for treating these conditions are provided comprising systemically administering an antiprogestin and contemporaneously locally administering an antiprogestin. Embodiments of the instant invention disclose methods for treating endometriosis, dysmenorrhea, breast cancer, uterine fibroids and endometrial hyperproliferation.
    Type: Application
    Filed: October 22, 2013
    Publication date: October 22, 2015
    Applicant: REPROS THERAPEUTICS INC.
    Inventors: Joseph S. PODOLSKI, Ronald D. WIEHLE