Abstract: A framed collectible for displaying a continuously-looping playback of a digital video file is provided, wherein a display panel is controlled by a display controller to play at least one video file in a continuous loop on the display panel only while an output signal from a magnet sensor indicates no proximity to a magnet proximal to the back side of the display panel. The display controller has a printed circuit board that incorporates at least one processor and at least one memory that contains at least one video file. The memory, which in an embodiment can be flash memory, is factory programmed and therefore the memory content cannot be changed by an end user. Packaging for storage and shipping of the framed collectible is also provided, which incorporates a magnet that is sensed by the magnet sensor to keep continuously-looping video playback switched off while the device is stored.

Abstract: A framed collectible for displaying a continuously-looping playback of a digital video file is provided, wherein a display panel is controlled by a display controller to play at least one video file in a continuous loop on the display panel only while an output signal from a magnet sensor indicates no proximity to a magnet proximal to the back side of the display panel. The display controller has a printed circuit board that incorporates at least one processor and at least one memory that contains at least one video file. The memory, which in an embodiment can be flash memory, is factory programmed and therefore the memory content cannot be changed by an end user. Packaging for storage and shipping of the framed collectible is also provided, which incorporates a magnet that is sensed by the magnet sensor to keep continuously-looping video playback switched off while the device is stored.

Abstract: Provided herein are the K-Ras inhibitors of the formulae: Also provided are compositions comprising thereof for treating cancer.

Abstract: A framed collectible for displaying a continuously-looping playback of a digital video file is provided, wherein a display panel is controlled by a display controller to play at least one video file in a continuous loop on the display panel only while an output signal from a magnet sensor indicates no proximity to a magnet proximal to the back side of the display panel. The display controller has a printed circuit board that incorporates at least one processor and at least one memory that contains at least one video file. The memory, which in an embodiment can be flash memory, is factory programmed and therefore the memory content cannot be changed by an end user. Packaging for storage and shipping of the framed collectible is also provided, which incorporates a magnet that is sensed by the magnet sensor to keep continuously-looping video playback switched off while the device is stored.

Abstract: A framed collectible for displaying a continuously-looping playback of a digital video file is provided, wherein a display panel is controlled by a display controller to play at least one video file in a continuous loop on the display panel only while an output signal from a magnet sensor indicates no proximity to a magnet proximal to the back side of the display panel. The display controller has a printed circuit board that incorporates at least one processor and at least one memory that contains at least one video file. The memory, which in an embodiment can be flash memory, is factory programmed and therefore the memory content cannot be changed by an end user. Packaging for storage and shipping of the framed collectible is also provided, which incorporates a magnet that is sensed by the magnet sensor to keep continuously-looping video playback switched off while the device is stored.

Abstract: A framed collectible for displaying a continuously-looping playback of a digital video file is provided, wherein a display panel is controlled by a display controller to play at least one video file in a continuous loop on the display panel only while an output signal from a magnet sensor indicates no proximity to a magnet proximal to the back side of the display panel. The display controller has a printed circuit board that incorporates at least one processor and at least one memory that contains at least one video file. The memory, which in an embodiment can be flash memory, is factory programmed and therefore the memory content cannot be changed by an end user. Packaging for storage and shipping of the framed collectible is also provided, which incorporates a magnet that is sensed by the magnet sensor to keep continuously-looping video playback switched off while the device is stored.

Abstract: Provided herein, inter alia, are methods and compounds for modulating K-Ras treating cancer.

Abstract: Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen-1-ium-1,2-diolates (O2-glycosylated diazeniumdiolates) and O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates (1-[(2-carboxylato)pyrrolidin-1-yl]diazeniumdiolates). The O2-aryl diazeniumdiolates are stable with respect to the hydrolytic generation of nitric oxide in neutral to acidic solutions and generate nitric oxide in basic or nucleophilic environments or microenvironments. Also provided are compositions, including pharmaceutical compositions, comprising such compounds and methods of using such compounds.

Abstract: Methods for enhancing detection by mass spectroscopy (MS) and/or chromatographic separability of carbonyl-containing compounds such as steroids are disclosed. Reaction of a carbonyl compound with a sulfonhydrazide compound provides a sulfonhydrazone with enhanced ionization efficiency during the electrospray ionization process. In a particularly disclosed embodiment, derivatization of catechol estrogens with p-toluenesulfonhydrazide enhances both detection by atmospheric pressure ionization-MS (API-MS), such as electron spray ionization-MS (ESI-MS) and separation by liquid chromatography (such as HPLC) under reverse phase conditions. In yet other embodiments, the sulfonhydrazone is further reacted with a sulfonyl halide under alkaline conditions to derivatize hydroxyl groups in the compound. Prior formation of the sulfonhydrazide derivative protects the carbonyl bond of the compound during subsequent alkaline reaction with the sulfonyl halide.

Abstract: Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.

Abstract: Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.

Abstract: Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.