Patents by Inventor Joseph Samuel Grimsby

Joseph Samuel Grimsby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENDOTHELIAL LIPASE ANTIBODIES FOR THE TREATMENT OF CARDIOVASCULAR DISEASES
    Publication number: 20230045712
    Abstract: The present disclosure provides methods of administering antibodies and antigen-binding fragments thereof that specifically bind to human endothelial lipase (EL) to a subject in need thereof, for example, a subject with cardiovascular disease.
    Type: Application
    Filed: November 6, 2020
    Publication date: February 9, 2023
    Inventors: Joseph Samuel GRIMSBY, Chao-Yu JIN, Judith FALLOON, Judith Ann HSIA, Sotirios K. KARATHANASIS, Richard Thomas GEORGE, Jr., John Edward LE LAY, Brian Timothy HUMMER, Yue HUANG, Anton I. ROSENBAUM
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Patent number: 7259166
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 10, 2006
    Date of Patent: August 21, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Patent number: 7105671
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: April 23, 2003
    Date of Patent: September 12, 2006
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators
    Publication number: 20030225283
    Abstract: 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: April 23, 2003
    Publication date: December 4, 2003
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Jagdish Kumar Racha, Ramakanth Sarabu, Ka Wang
  • Fused heteroaromatic glucokinase activators
    Patent number: 6545155
    Abstract: Glucokinase activating amides useful for increasing insulin secretion in the treatment of type II diabetes are disclosed.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: April 8, 2003
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6448399
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: September 10, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6441184
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 27, 2002
    Assignee: Hoffmann-LA Roche Inc.
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Patent number: 6433188
    Abstract: Glucokinase activating amides as herein disclosed are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: August 13, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • FUSED HETEROAROMATIC GLUCOKINASE ACTIVATORS
    Publication number: 20020107396
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 8, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu
  • Fused heteroaromatic glucokinase activators
    Publication number: 20020103199
    Abstract: Glucokinase activating amides are useful for increasing insulin secretion in the treatment of type II diabetes.
    Type: Application
    Filed: December 4, 2001
    Publication date: August 1, 2002
    Inventors: Wendy Lea Corbett, Joseph Samuel Grimsby, Nancy-Ellen Haynes, Robert Francis Kester, Paige Erin Mahaney, Ramakanth Sarabu