Abstract: Disclosed herein are improved assays, cartridges, kits, and methods of use thereof for detecting biomarkers, e.g., one or more biomarkers of brain injury, including, without limitation, biomarkers of acquired brain injury (ABI), such as, traumatic brain injury (TBI). The improved assays described herein may aid in the diagnosis and evaluation of a subject (e.g., a human subject) that has sustained or may have sustained an injury to the head (e.g., TBI) by detecting levels of a biomarker, such as UCH-L1, GFAP, or a combination thereof, in samples taken from a subject (e.g., a human subject).

Abstract: A drive assembly for driving an imaging catheter has a rotatable fiber and a rotatable drive shaft. The drive assembly includes a fiber optic rotating junction and a motor configured to rotate the rotatable portion of the fiber optic rotating junction. In some embodiments, the drive assembly includes a sensor configured to detect a rotational position of the fiber optic rotating junction and a processor configured to obtain the detected rotational position and stop the motor only when the fiber optic rotating junction is in a predetermined rotational position. In some embodiments, the motor includes a hollow shaft through which at least a portion of the fiber optic rotating junction extends.

Abstract: Systems, methods, and computer programs for providing a force opposed to inertial forces present on a patterning device during imaging operations of a photolithographic system include a means for providing coarse positioning of a pusher in combination with a short-stroke actuator and pushing tip configured to engage an edge of the patterning device. In an embodiment, the coarse positioning is provided by providing a guide along which the short-stroke actuator may be translated, and a locking mechanism is configured to selectively hold the actuator in place relative to the patterning device. In an embodiment, the coarse positioning is provided by a long-stroke actuator, for example an eccentric linear drive actuator.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to an electrosurgical surgical tip that includes a conductive and low-profile cutting surface to provide high current density radiofrequency energy with minimal thermal damage to surrounding tissues. For example, an electrosurgical tip of the present disclosure may include a ring of conductive material sputter-coated around a distal opening of a non-conductive base component and a strip of conductive material sputter-coated along a longitudinal axis of the non-conductive base component.

Abstract: A platform which provides a system and method for loan origination data validation and predictive analysis comprising a user interface which allows platform users to upload data, a data acquisition engine that leverages one or more machine and/or deep learning algorithms to classify, validate, and enforce compliance of the uploaded data, and an artificial intelligence engine that constructs and maintains the models developed from the machine and/or deep learning algorithms. The platform may utilize various bespoke APIs to integrate validated data with lender institution loan origination systems when a lender initiates the process. The platform can function as a system of record and central, secure repository for a borrower's documentation and information required to apply for a loan. In some embodiments, the platform utilizes a trained generative AI model to assist platform users and to provide predictive analysis responsive to user submitted queries.

Abstract: A paint brush having an integrated hanger assembly for hanging the paint brush on an object. The hanger assembly may be discrete with respect to at least the upper elongated portion of the handle, and may be provided as an insert assembly in a pocket of the handle. The hanger assembly includes a body part having a surface groove, and a hanger hinged to the body part for enabling the hanger to pivotably move between a retracted position stowed in the surface groove, and an extended position extending from the surface groove for hanging the paint brush from the object. A connection portion of the hanger may include laterally spaced apart arms and a pivot rod extending between the laterally spaced apart arms to form a connection loop. A connector may interloop with the connection loop to connect the hanger to the body part.

Abstract: Systems and methods for multiple device consumption of shared namespaces of ephemeral storage devices by a consumer of a virtual storage system are provided. In an example, multiple namespaces of respective ephemeral storage devices are shared among multiple of consumers of a virtual storage system by creating multiple partitions within each of the namespaces for use by respective consumers of the multiple consumers. Corresponding partitions of respective shared namespace may then be treated as a stripe set to facilitate multiple device consumption for a subsystem (e.g., operation log journaling) of the virtual storage system by striping data associated with input/output (I/O) requests of a consumer (e.g., a journaling driver) across one or more stripe units of one or more stripes within the stripe set.

Abstract: A step assembly for a work vehicle includes a top portion configured to engage a base portion of the step assembly while in an engaged state. The top portion is configured to be disposed above the base portion while in the engaged state. The top portion is also configured to cover an operational component of the work vehicle while in the engaged state. The top portion is also configured to be disposed on a ground surface while in a disengaged state to support a standing operator in a stable configuration and to elevate the standing operator relative to the ground surface.

Abstract: Systems and methods for sharing a namespace of an ephemeral storage device by multiple consumers are provided. In an example, an NVMe driver of a virtual storage system deployed within a compute instance of a cloud environment facilitates sharing of the namespace by exposing an API through which the multiple consumers access an ephemeral storage device associated with the compute instance. During initialization processing performed by each consumer, for example, during boot processing of the virtual storage system, the consumers may share the namespace by reserving for their own use respective partitions within the namespace via the API and thereafter restrict their usage of the namespace to their respective partitions, thereby retaining the functionality provided by the multiple consumers when the host on which the compute instance is deployed has fewer ephemeral storage devices than consumers that rely on the availability of vNVRAM backed by ephemeral storage.

Abstract: Provided is a method of transportation information exchange that includes receiving first data from a first aviation data source, such that the first data is provided in a first data format type and determining, based on a set of routing rules, a first aviation consumer of at least a first portion of the first data. The method further includes processing the first portion of the first data into a second data format type associated with the first aviation consumer and providing the first portion of the first data in the second data format type to the first aviation consumer.

Abstract: A patient support may be adjustable in height, width, length or a combination thereof. The patient support may be useable with normal sized patients or with bariatric patients. The patient support has a variety of features to enhance operability and/or functionality, including a width adjustable caster frame, width adjustable deck portions, a width adjustable headboard and an extendible foot board to provide extra length. An enhanced lift mechanism can accommodate bariatric patients and alternative functionality in achieving deck positions improves patient comfort. Various parts of the patient support including deck panels and the footboard may be removed and replaced with ease without complicated connectors.

Abstract: An apparatus for use in manufacturing a component of an implantable medical device comprises a fixture comprising a first fixture member having a plurality of semi-circular recesses in a lower surface thereof, and a second fixture member having a plurality of semi-circular recesses in an upper surface thereof, the first and second fixture members being configured to be selectively fastened together via a plurality of fasteners, wherein in an assembled state of the fixture, each of the semi-circular recesses of the first fixture member lower surface is aligned with an opposing semi-circular recess in the second fixture member upper surface to define a plurality of workpiece openings each dimensioned to receive and secure a respective work piece to be machined to the fixture.

Abstract: Various embodiments are directed to processing conversions of digital assets to other digital assets. An example method includes determining a source exchange rate for a source digital asset and a fiat currency, determining a target exchange rate for a target digital asset and a fiat currency, and generating an aggregated conversion rate for the source digital asset and the target digital asset using the source exchange rate and the target exchange rate. The method further includes executing a digital asset conversion, which includes causing source digital asset units to be debited from a source digital asset user account and causing target digital asset units to be credited to a target digital asset user account, and subsequently executing fiat currency transactions (e.g., settlements) with a first digital asset exchange system associated with the source digital asset and a second digital asset exchange system associated with the target digital asset.

Abstract: A paint brush having an integrated hanger assembly for hanging the paint brush on an object. The hanger assembly may be discrete with respect to at least the upper elongated portion of the handle, and may be provided as an insert assembly in a pocket of the handle. The hanger assembly includes a body part having a surface groove, and a hanger hinged to the body part for enabling the hanger to pivotably move between a retracted position stowed in the surface groove, and an extended position extending from the surface groove for hanging the paint brush from the object. A connection portion of the hanger may include laterally spaced apart arms and a pivot rod extending between the laterally spaced apart arms to form a connection loop. A connector may interloop with the connection loop to connect the hanger to the body part.

Abstract: A method for predicting a property of a sample molecule involves, for each of a multitude of reference molecules, obtaining a multitude of fingerprints and at least one property, and obtaining the multitude of fingerprints of the sample molecule. The method further involves for each of the multitude of reference molecules, using each of the multitude of fingerprints, calculating distances to the sample molecule, and for each of the multitude of reference molecules, determining a relative predictive dominance, based on the distances to the sample molecule. The method also involves, for each of the multitude of reference molecules, determining a fitness value based on the relative predictive dominance, and predicting the at least one property of the sample molecule based on the at least one property of the multitude of reference molecules and the fitness values obtained for the reference molecules.

Abstract: Techniques for analyzing driving simulations and determining simulation stability metrics are discussed herein. Various techniques may include receiving a driving simulation and determining a number of perturbed simulations based on the driving simulation. The perturbed simulations may include, for example, one or more perturbed object attributes, perturbed simulation failure conditions, and/or perturbed behaviors of the vehicle system on which the simulation is executed. The perturbed simulations may be executed, and the results may be analyzed to determine a stability score associated with the driving simulation. Stability scores for driving simulations may be determined and maintained based on different simulation data perturbations received based on perturbation models, and the stability scores may be used in various implementations to generate simulation batteries for regression testing and for analyzing and routing simulation failures.

Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

Abstract: A laser weapon system is described. Particularly, embodiments describe subsystems of a laser weapon system including those necessary for laser generation, operational control, optical emission, and heat dissipation configured to provide a lightweight unit of reduced dimensions.