Patents by Inventor Joseph Semple

Joseph Semple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases
    Publication number: 20080070867
    Abstract: Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. The compounds for use in the compositions and methods provided herein have formulae (I) Protein tyrosine phosaphatase, including PTB-IB, mediated diseases and disorders include diabetes including Type 1 and Type 2 diabetes (and associated complications such as hypertension, ischemic diseases of the large and small blood vessels, blindness, circulatory problems, kidney failure and atherosclerosis), syndrome X, metabolic syndrome, glucose intolerance, insulin resistance, obesity, cancer, and neurodegenerative diseases.
    Type: Application
    Filed: January 17, 2006
    Publication date: March 20, 2008
    Applicant: Metabasis Therapeutics, Inc.
    Inventors: Zacharia Cheruvallath, Joseph Semple, Vasanthakumar Rajappan, Darryl Rideout, Venkatachalapathi Yalamoori, Chung-Ying Tsai, Feiyue Wu, Lars Thoresen, Mark Shenderovich
  • Thiazole and thiadiazole inhibitors of tyrosine phosphatases
    Publication number: 20060194768
    Abstract: Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.
    Type: Application
    Filed: September 2, 2005
    Publication date: August 31, 2006
    Inventors: Zacharia Cheruvallath, Colin Loweth, Ruth Nutt, Darryl Rideout, Joseph Semple, Jing Wang, Feiyue Wu, Shankari Mylvaganam, Hengyi Zhu, Jianzhong Sun
  • Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases
    Publication number: 20060135483
    Abstract: Compounds, pharmaceutical compositions, and methods for treating, preventing, or ameliorating symptoms associated with diseases such as diabetes, cancer, neurodegenerative diseases, and obesity are provided. The compounds and compositions inhibit protein tyrosine phosphatase enzymes, e.g., PTP-1B.
    Type: Application
    Filed: July 8, 2005
    Publication date: June 22, 2006
    Inventors: Zacharia Cheruvallath, Joseph Semple, Jing Wang, Ruth Nutt, Shankari Mylvaganam
  • Trisubstituted nitrogen modulators of tyrosine phosphatases
    Publication number: 20060135773
    Abstract: Compounds, compositions and methods are provided for modulating the activity of protein tyrosine phosphatases, including PTP-1B. In one embodiment, the compounds are N,N-dibenzylarylsulfonamides.
    Type: Application
    Filed: June 17, 2005
    Publication date: June 22, 2006
    Inventors: Joseph Semple, Darryl Rideout, Ruth Nutt, Mark Shenderovich, Jing Wang, Shankari Mylvaganam, Feiyue Wu, Chung Tsai, Venkatachalapathi Yalamoori, Colin Loweth