Patents by Inventor Joseph Shapiro
Joseph Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Methods for treatment and diagnosis of non-alcoholic steatohepatitis and/or hepatocellular carcinoma
Patent number: 11958915Abstract: Methods for treating non-alcoholic steatohepatitis and/or hepatocellular carcinoma include administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. Methods and assays for diagnosis or prognosis of non-alcoholic steatohepatitis and/or hepatocellular carcinoma in a subject are also provided and include the steps of providing a biological sample from the subject, determining an expression level or activity in the sample of at least one biomarker selected from Caveolin-1, Survivin, and SMAC; and comparing the expression level or activity of the at least one biomarker in the sample, if present, to a control expression level or activity of the at least one biomarker. Prophylaxis or treatment of the non-alcoholic steatohepatitis and/or hepatocellular carcinoma in a subject can then be initiated based on the expression level or activity of Caveolin-1, Survivin, and SMAC in the sample.Type: GrantFiled: April 6, 2021Date of Patent: April 16, 2024Assignee: MARSHALL UNIVERSITY RESEARCH CORPORATIONInventors: Juan Sanabria, Sandrine Pierre, Moumita Banerjee, Zijian Xie, Joseph Shapiro -
Patent number: 11952274Abstract: A method for producing hydrogen product having a low carbon intensity is provided. The method includes the steps of: (a) converting a hydrocarbon feedstock to a hydrogen product using a hydrocarbon reforming process; (b) providing at least some of the required energy for the hydrogen production process from a biomass power plant; and (c) processing one or more flue gas streams from the biomass power plant in a carbon capture unit to reduce CO2e emissions. The hydrogen product has a carbon intensity preferably less than about 1.0 kg CO2e/kg H2, more preferably less than 0.45 kg CO2e/kg H2, and most preferably less than 0.0 kg CO2e/kg H2.Type: GrantFiled: March 7, 2023Date of Patent: April 9, 2024Assignee: Kraken Technology Holdings, LLCInventors: Byron Gladus Best, III, Christopher Michael Miller, Anna Louise Buckley, John Edwin Plumlee, Bengt Arne Jarlsjo, Daniel Joseph Shapiro
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Patent number: 11952272Abstract: A method for producing hydrogen product having a low carbon intensity is provided. The method includes the steps of: (a) converting a hydrocarbon feedstock to a hydrogen product using a hydrocarbon reforming process; (b) providing at least some of the required energy for the hydrogen production process from a biomass power plant; and (c) processing one or more flue gas streams from the biomass power plant in a carbon capture unit to reduce CO2e emissions. The hydrogen product has a carbon intensity preferably less than about 1.0 kg CO2e/kg H2, more preferably less than 0.45 kg CO2e/kg H2, and most preferably less than 0.0 kg CO2e/kg H2.Type: GrantFiled: March 8, 2023Date of Patent: April 9, 2024Assignee: Kraken Technology Holdings, LLCInventors: Byron Gladus Best, III, Christopher Michael Miller, Anna Louise Buckley, John Edwin Plumlee, Bengt Arne Jarlsjo, Daniel Joseph Shapiro
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Patent number: 11952276Abstract: A method for producing hydrogen product having a low carbon intensity is provided. The method includes the steps of: (a) converting a hydrocarbon feedstock to a hydrogen product using a hydrocarbon reforming process; (b) providing at least some of the required energy for the hydrogen production process from a biomass power plant; and (c) processing one or more flue gas streams from the biomass power plant in a carbon capture unit to reduce CO2e emissions. The hydrogen product has a carbon intensity preferably less than about 1.0 kg CO2e/kg H2, more preferably less than 0.45 kg CO2e/kg H2, and most preferably less than 0.0 kg CO2e/kg H2.Type: GrantFiled: March 6, 2023Date of Patent: April 9, 2024Assignee: Kraken Technology Holdings, LLCInventors: Byron Gladus Best, III, Christopher Michael Miller, Anna Louise Buckley, John Edwin Plumlee, Bengt Arne Jarlsjo, Daniel Joseph Shapiro
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Publication number: 20240101416Abstract: A method for producing hydrogen product having a low carbon intensity is provided. The method includes the steps of: (a) converting a hydrocarbon feedstock to a hydrogen product using a hydrocarbon reforming process; (b) providing at least some of the required energy for the hydrogen production process from a biomass power plant; and (c) processing one or more flue gas streams from the biomass power plant in a carbon capture unit to reduce CO2e emissions. The hydrogen product has a carbon intensity preferably less than about 1.0 kg CO2e/kg H2, more preferably less than 0.45 kg CO2e/kg H2, and most preferably less than 0.0 kg CO2e/kg H2.Type: ApplicationFiled: March 7, 2023Publication date: March 28, 2024Inventors: Byron Gladus Best, III, Christopher Michael Miller, Anna Louise Buckley, John Edwin Plumlee, Bengt Arne Jarlsjo, Daniel Joseph Shapiro
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Publication number: 20240101497Abstract: A method for producing an olefin product, including the steps of converting a hydrocarbon feedstock to an unsaturated hydrocarbon stream through a steam cracking process in an olefins production plant; combusting hydrogen to provide at least some of the heating duty to the steam cracking process, wherein the hydrogen has a carbon intensity less than about 1.0 kg CO2e/kg H2, wherein the hydrogen is produced using a hydrogen production process; providing at least some of the required energy for the hydrogen production process from a biomass power plant; and processing the unsaturated hydrocarbon stream to recover the olefin product. The olefin product may comprise ethylene having a well-to-gate carbon intensity less than about 0.6 kg CO2e/kg C2H4, or may comprise propylene having a well-to-gate carbon intensity less than about 0.6 kg CO2e/kg C3H6.Type: ApplicationFiled: September 25, 2023Publication date: March 28, 2024Inventors: Christopher Michael MILLER, Gregory David SMITH, Anna Louise BUCKLEY, Byron Gladus BEST, III, Bengt Arne JARLSJO, Dainel Joseph SHAPIRO
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Publication number: 20240102403Abstract: A method for providing energy from waste heat from an electrolysis process to one or more commercial or industrial operations is provided. The method includes the steps of converting water to oxygen and a hydrogen product through an electrolysis process, wherein the hydrogen product has a carbon intensity less than about 0.45 kg CO2e/kg H2, and wherein at least some of the required energy for the electrolysis process is provided from a biomass power plant. The method further includes recovering waste heat from the electrolysis process, and then converting at least some of the waste heat to thermal energy for use in the one or more commercial or industrial operations. Examples of commercial and industrial operations includes, without limitation, greenhouses, algae farms, district cooling, and district heating.Type: ApplicationFiled: September 22, 2023Publication date: March 28, 2024Inventors: Christopher Michael MILLER, Anna Louis BUCKLEY, Byron Gladus BEST, III, Bengt Arne JARLSJO, Daniel Joseph SHAPIRO
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Publication number: 20240102179Abstract: Methods for producing a hydrogen product having a carbon intensity less than about 0.45 kg CO2e/kg H2 is provided. The method includes the steps of converting water to oxygen and the hydrogen product through an electrolysis process, providing at least some, and substantially all, of the required energy for the electrolysis process from a biomass power plant, and processing one or more flue gas streams from the biomass power plant in a carbon capture unit to reduce CO2e emissions. The energy produced from the biomass power plant may comprise one or more of electricity, steam used as process steam in the electrolysis process, steam used as thermal energy in the electrolysis process, and steam used to power a mechanical drive for one or more compressors, pumps, or other motors generating shaft torque in the electrolysis process.Type: ApplicationFiled: September 21, 2023Publication date: March 28, 2024Inventors: Christopher Michael MILLER, Anna Louise BUCKLEY, Byron Gladus BEST, III, Bengt Arne JARLSJO, Daniel Joseph SHAPIRO
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Publication number: 20240101414Abstract: A method for producing hydrogen product having a low carbon intensity is provided. The method includes the steps of: (a) converting a hydrocarbon feedstock to a hydrogen product using a hydrocarbon reforming process; (b) providing at least some of the required energy for the hydrogen production process from a biomass power plant; and (c) processing one or more flue gas streams from the biomass power plant in a carbon capture unit to reduce CO2e emissions. The hydrogen product has a carbon intensity preferably less than about 1.0 kg CO2e/kg H2, more preferably less than 0.45 kg CO2e/kg H2, and most preferably less than 0.0 kg CO2e/kg H2.Type: ApplicationFiled: March 8, 2023Publication date: March 28, 2024Inventors: Byron Gladus Best, III, Christopher Michael Miller, Anna Louise Buckley, John Edwin Plumlee, Bengt Arne Jarlsjo, Daniel Joseph Shapiro
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Publication number: 20240101419Abstract: A method for producing hydrogen product having a low carbon intensity is provided. The method includes the steps of: (a) converting a hydrocarbon feedstock to a hydrogen product using a hydrocarbon reforming process; (b) providing at least some of the required energy for the hydrogen production process from a biomass power plant; and (c) processing one or more flue gas streams from the biomass power plant in a carbon capture unit to reduce CO2e emissions. The hydrogen product has a carbon intensity preferably less than about 1.0 kg CO2e/kg H2, more preferably less than 0.45 kg CO2e/kg H2, and most preferably less than 0.0 kg CO2e/kg H2.Type: ApplicationFiled: March 6, 2023Publication date: March 28, 2024Inventors: Byron Gladus Best, III, Christopher Michael Miller, Anna Louise Buckley, John Edwin Plumlee, Bengt Arne Jarlsjo, Daniel Joseph Shapiro
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Publication number: 20230354846Abstract: An ice cream maker may comprise a sealed inner shell containing ice cream mixture; a sealed outer shell containing salt, ice, and the inner shell; and an insulated bag containing the sealed outer shell. Ice cream may be made by tumbling the insulated bag (containing the outer shell and inner shell) in a dryer.Type: ApplicationFiled: May 3, 2023Publication date: November 9, 2023Inventors: Joseph Shapiro, Kelly Browne
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Publication number: 20230130102Abstract: Na/K-ATPase ligands are provided that comprise a compound of formula (I) and are capable of binding to the ?1 Na/K-ATPase and decreasing the endocytosis of ?1 Na/K-ATPase, such that expression of the ?1 Na/K-ATPase is restored in the plasma membrane of cells and tumor growth and invasion is reduced. Pharmaceutical compositions are further provided that include a compound of formula (I) and a pharmaceutically-acceptable vehicle, carrier, or excipient. Methods of treating a cancer are further included and comprise administering to a subject an effective amount of a Na/K-ATPase ligand.Type: ApplicationFiled: October 8, 2020Publication date: April 27, 2023Inventors: Zijian XIE, Moumita BANERJEE, Joseph SHAPIRO, Yingnyu GAO, Maosheng DUAN, Xuchai TAN
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METHODS FOR TREATMENT AND DIAGNOSIS OF NON-ALCOHOLIC STEATOHEPATITIS AND/OR HEPATOCELLULAR CARCINOMA
Publication number: 20210309698Abstract: Methods for treating non-alcoholic steatohepatitis and/or hepatocellular carcinoma include administering a polypeptide antagonist of a Na/K ATPase/Src receptor complex to a subject in need thereof. Methods and assays for diagnosis or prognosis of non-alcoholic steatohepatitis and/or hepatocellular carcinoma in a subject are also provided and include the steps of providing a biological sample from the subject, determining an expression level or activity in the sample of at least one biomarker selected from Caveolin-1, Survivin, and SMAC; and comparing the expression level or activity of the at least one biomarker in the sample, if present, to a control expression level or activity of the at least one biomarker. Prophylaxis or treatment of the non-alcoholic steatohepatitis and/or hepatocellular carcinoma in a subject can then be initiated based on the expression level or activity of Caveolin-1, Survivin, and SMAC in the sample.Type: ApplicationFiled: April 6, 2021Publication date: October 7, 2021Inventors: Juan Sanabria, Sandrine Pierre, Moumita Banerjee, Zijian Xie, Joseph Shapiro -
Publication number: 20200157568Abstract: Expression vectors are provided that comprise a nucleic acid sequence encoding a polypeptide antagonist of a Na/K ATPase/Src receptor complex. The nucleic acid encoding the polypeptide antagonist is operatively linked to a promoter for expressing the polypeptide antagonist in a specific cell or tissue. Viral particles, target cells, and pharmaceutical compositions are also provided and include the expression vectors. Methods of treating a Src-associated disease is further provided and includes administering the expression vectors encoding the polypeptide antagonist of the Na/K ATPase/Src receptor complex to a subject in need thereof.Type: ApplicationFiled: May 25, 2018Publication date: May 21, 2020Inventors: Zijian XIE, Komal SODHI, Nader ABRAHAM, Rebecca MARTIN, Joseph SHAPIRO
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Patent number: 9686133Abstract: Embodiments relate to dynamically establishing and reconfiguring connection channels. More specifically, performance metrics for each agent may be quantitatively assessed, complementary agents may be identified based on the performance metrics, and connection channels may be established between the complementary agents. Performance metrics may continue to be monitored, and connection channels may be reconfigured so as to improve individual agents' metrics or a cluster of agents' metrics.Type: GrantFiled: March 7, 2016Date of Patent: June 20, 2017Assignee: PEARSON EDUCATION, INC.Inventors: Alec Anton Lazarescu, Mathew Joseph Shapiro
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Publication number: 20170078141Abstract: Embodiments relate to dynamically establishing and reconfiguring connection channels. More specifically, performance metrics for each agent may be quantitatively assessed, complementary agents may be identified based on the performance metrics, and connection channels may be established between the complementary agents. Performance metrics may continue to be monitored, and connection channels may be reconfigured so as to improve individual agents' metrics or a cluster of agents' metrics.Type: ApplicationFiled: March 7, 2016Publication date: March 16, 2017Inventors: Alec Anton Lazarescu, Mathew Joseph Shapiro
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Patent number: 9313098Abstract: Embodiments relate to dynamically establishing and reconfiguring connection channels. More specifically, performance metrics for each agent may be quantitatively assessed, complementary agents may be identified based on the performance metrics, and connection channels may be established between the complementary agents. Performance metrics may continue to be monitored, and connection channels may be reconfigured so as to improve individual agents' metrics or a cluster of agents' metrics.Type: GrantFiled: September 10, 2015Date of Patent: April 12, 2016Assignee: PEARSON EDUCATION, INC.Inventors: Alec Anton Lazarescu, Matthew Joseph Shapiro
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Patent number: 9264662Abstract: There is disclosed a system and a method of initiating a one-click video chat session. The method includes accessing a database to determine whether the target chat participant has pre-authorized the source chat participant to initiate a chat without requiring acceptance of the chat request, a source chat participant sending a chat request requesting a chat session with a target chat participant while a computing device associated with the target chat participant is not generating any audio component nor any video component, and causing the computing device associated with the target chat participant to begin providing at least one of an audio component and a video component to the source chat participant without any action on the part of the target chat participant.Type: GrantFiled: December 30, 2013Date of Patent: February 16, 2016Assignee: OnCam Inc.Inventor: Joseph Shapiro
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Publication number: 20150189230Abstract: There is disclosed a system and a method of initiating a one-click video chat session. The method includes accessing a database to determine whether the target chat participant has pre-authorized the source chat participant to initiate a chat without requiring acceptance of the chat request, a source chat participant sending a chat request requesting a chat session with a target chat participant while a computing device associated with the target chat participant is not generating any audio component nor any video component, and causing the computing device associated with the target chat participant to begin providing at least one of an audio component and a video component to the source chat participant without any action on the part of the target chat participant.Type: ApplicationFiled: December 30, 2013Publication date: July 2, 2015Applicant: OnCam, Inc.Inventor: Joseph Shapiro
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Publication number: 20150188928Abstract: There is disclosed a system and a method for public-private chat functionality. The method includes initiating a private chat between a first chat participant using a first computing device and a second chat participant using a second computing device and receiving a request to convert the private chat into a public chat available for viewing by a plurality of non-participating chat viewers, the request from the first computing device. The method further includes receiving an acceptance of the request to convert from the second computing device, automatically sending a notification to followers of at least one of the first chat participant and the second chat participant that the public chat is about to commence, and enabling access to the chat by the plurality of non-participating chat viewers.Type: ApplicationFiled: December 30, 2013Publication date: July 2, 2015Applicant: OnCam, Inc.Inventor: Joseph Shapiro