Abstract: Enterically-coated solid dosage forms containing a pharmaceutical agent which includes bacteria and/or microbial extracellular vesicles (mEVs) are provided. Methods of treatment using such solid dosage forms are also provided.

Abstract: The present disclosure relates to methods for reducing the oxidation level of cysteine residues in recombinant polypeptides such as anti-IL-17 antibodies during cell culture (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of recombinant polypeptides such as anti-IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab. Also provided are purified preparations of recombinant polypeptides produced by such methods wherein the level of active recombinant polypeptide in the preparation is high.

Abstract: Provided herein is a device (and associated method of using the device) to aid and educate a child in blowing their nose. The device comprises a pinwheel assembly, which is positioned under the child's nostrils such that air expelled from the nostrils will turn the blades of the pinwheel. The device optionally comprises a pacifier, which is configured such that when the nipple of the pacifier is in the child's mouth, the pinwheel assembly is positioned such that air expelled from the child's nostrils will turn the blades of the pinwheel assembly. Other configurations include cups, which encircle the child's mouth, and handles which aid in the proper positioning of the device.

Abstract: Provided herein is a device (and associated method of using the device) to aid and educate a child in blowing their nose. The device comprises a pinwheel assembly, which is positioned under the child's nostrils such that air expelled from the nostrils will turn the blades of the pinwheel. The device optionally comprises a pacifier, which is configured such that when the nipple of the pacifier is in the child's mouth, the pinwheel assembly is positioned such that air expelled from the child's nostrils will turn the blades of the pinwheel assembly. Other configurations include cups, which encircle the child's mouth, and handles which aid in the proper positioning of the device.