Abstract: The present invention is directed to beneficially directing the bidirectional communication that exists between the brain and the gut so as to influence brain physiology, psychological responses and ultimately behavior in a positive manner by regulating an individual's mood, psychological symptoms, such as anxiety and depression and stress-related changes in brain function, by modifying the gut microbiome of an individual. An various embodiments, an individual's microbiome is modified in a manner to reduce the likelihood of stress, to reduce or treat symptoms affecting mental health and to promote the mental health of the individual. In certain embodiments, administration to an individual of at least three different bacteria species are combined to modify an individual's microbiome, selected from the group of Lacticaseibacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L.

Abstract: The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.

Abstract: The present invention relates to a wheel for motor vehicles that incorporates a planetary gear system within the wheel assembly. The wheel aims to increase the mechanical advantage of the wheel by providing additional rotation to the wheel axis of the vehicle, thus reducing the amount of fuel exhausted by the vehicle during transit. By utilizing an internal and planetary gear system with integrated motors housed within the wheel, the tire of the wheel is able to rotate independently from the axel of the vehicle in the same direction, thus providing an increased power output.

Abstract: This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.

Abstract: This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation. The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.

Abstract: A patient immobilization device for radiotherapy includes a one-piece composite body having a core and a carbon fiber reinforced skin encapsulating the core. The composite body further includes a posterior surface configured for mounting the composite body upon a radiotherapy support table, and an anterior surface defining a cradle. Positioning a patient upon the immobilization device and supporting the patient with the cradle enables emitting therapeutic radiation towards a craniospinal treatment site of the patient from a posterior side of the immobilization device while the patient is supported in a supine position. The emitted radiation may include proton beam radiation.

Abstract: A system and method for designing an HVAC system using a database to manage values of properties corresponding to design elements. Elements include substantially all physical components and connections available for creating an HVAC system design. A user interface represents design elements arbitrarily selectable by a user and connectable to one another in a schematic to establish the HVAC system design. The system may provide, automatically, default values corresponding to the properties corresponding to the design elements. A user may select arbitrarily, from the design elements, an arbitrary number of selected design elements to be interconnected in the HVAC system design. A user may place and interconnect each arbitrary design element, while the system calculates, automatically, values of properties characterizing the arbitrary design elements; validating correctness of the interconnections and properties, calculating performance parameters, and providing drawings.

Abstract: A cord holding device and method of use. An embodiment of the device includes a sheet of material having a turned end. The turned end is selectively positionable between a closed orientation and an open orientation. In the open orientation, an opening is formed between the turned end and the sheet to allow for the cord to be inserted within an interior section. In the closed orientation, the turned end wraps around the cord to retain it within the device. A method of using the device comprises mounting the device to a position to receive the cord. A holding section is unturned an amount to allow for the cord to be inserted within the interior section of the holding section. After cord insertion, the holding section re-turns and wraps around the cord.

Abstract: A disc brake caliper for conversion of a motorcycle with a linked braking system to a trike integrates two or more separate sets of opposed braking cylinders and pads within a single housing. Braking cylinder sets are not connected to other braking cylinder sets within the housing. Each set of braking cylinders is connected to and actuated independently by a different master cylinder. At least two braking cylinder sets within a housing have different diameters, the diameters of each set being chosen to produce a desired amount of braking pressure in response to an expected amount of hydraulic pressure from a master cylinder actuating the set. Both the diameter of each braking cylinder set and ratio of diameters between different braking cylinder sets are chosen to produce the optimum rear wheel braking pressure allocation for a given braking control system and vehicle configuration with no changes to the master cylinders or the front wheel braking system.

Abstract: A cord holding device and method of use. An embodiment of the device includes a sheet of material having a turned end. The turned end is selectively positionable between a closed orientation and an open orientation. In the open orientation, an opening is formed between the turned end and the sheet to allow for the cord to be inserted within an interior section. In the closed orientation, the turned end wraps around the cord to retain it within the device. A method of using the device comprises mounting the device to a position to receive the cord. A holding section is unturned an amount to allow for the cord to be inserted within the interior section of the holding section. After cord insertion, the holding section re-turns and wraps around the cord.

Abstract: A foot support structure of the type used with a stilt includes a foot platform, a side wall, and first and second adjustable retaining members. The foot platform includes opposed first and second primary surfaces, a toe end, a heel end, and first and second sides. The side wall extends in a substantially normal direction from the first primary surface and extends along at least a portion of the first and second sides and a portion of the heel end of the base member. The front and rear adjustable retaining members are coupled to the side wall and extend between the first and second sides of the foot platform.

Abstract: A disc brake caliper for conversion of a motorcycle with a linked braking system to a trike integrates two or more separate sets of opposed braking cylinders and pads within a single housing. Braking cylinder sets are not connected to other braking cylinder sets within the housing. Each set of braking cylinders is connected to and actuated independently by a different master cylinder. At least two braking cylinder sets within a housing have different diameters, the diameters of each set being chosen to produce a desired amount of braking pressure in response to an expected amount of hydraulic pressure from a master cylinder actuating the set. Both the diameter of each braking cylinder set and ratio of diameters between different braking cylinder sets are chosen to produce the optimum rear wheel braking pressure allocation for a given braking control system and vehicle configuration with no changes to the master cylinders or the front wheel braking system.

Abstract: This invention relates to the immobilization of toxic materials, e.g., radioactive materials, in glass for extremely long periods of time. Toxic materials, such as radioactive wastes, which may be in the form of liquids, or solids dissolved or dispersed in liquids or gases, are deposited in a glass container which is heated to evaporate off non-radioactive volatile materials, if present; to decompose salts, such as nitrates, if any, and to drive off volatile non-radioactive decomposition products, and then to collapse the walls of said container on said radwaste and seal the container and immobilize the contained radwaste, and then burying the resulting product underground or at sea. In another embodiment, the glass container also contains glass particles, e.g., spheres or granules, on which the radwaste solids are deposited.

Abstract: This invention relates to the immobilization of toxic materials, e.g., radioactive materials, in glass for extremely long periods of time. Toxic materials, such as radioactive wastes, which may be in the form of liquids, or solids dissolved or dispersed in liquids or gases, are deposited in a glass container which is heated to evaporate off non-radioactive volatile materials, if present; to decompose salts, such as nitrates, if any, and to drive off volatile non-radioactive decomposition products, and then to collapse the walls of said container on said radwaste and seal the container and immobilize the contained radwaste, and then burying the resulting product underground or at sea. In another embodiment, the glass container also contains glass particles, e.g., spheres or granules, on which the radwaste solids are deposited.

Abstract: A deflector for use on an automatic molding machine deflects incoming sand downwardly onto the drag table and then upwardly into deep recesses in the pattern. The sand deflector is formed as a rectangular prism from a single block of metal, and has two deflecting channels separated by a strengthening septum. The channels are arranged at a predetermined angle in relation to the mounting surface of the deflector.