Abstract: In an embodiment, a data processing method providing an improvement in computer efficiency in transmitting data poll messages to another computer, the method comprising: using a first computer, transmitting a first plurality of data poll messages to a second computer, receiving event data from the second computer, and storing the event data in event history storage; based upon the event data in the event history storage, calculating a first estimate of a probability of a particular event occurring in a first specified time period; in response to determining that the first estimate is greater than 0, calculating a total number of times to check for the same particular event in the same specified time period; based upon the event data in the event history storage, calculating a second estimate of a probability distribution of the same particular event during the same specified time period; creating and storing a schedule of a plurality of times at which to transmit a second plurality of data poll messages to th

Abstract: Described herein are novel methods for treating subjects with a cancer which is not overexpressing at least one of BCL-xL, BCL-w, and BAD, and optionally further overexpressing BCL-2. Also provided herein are tools for determining and/or assessing, and for the administration of, cancer treatments involving BET bromodomain inhibitors, BCL-xL inhibitors, or combinations thereof.

Abstract: A method and system for environmental control and supplementary power generation in conventional and hybrid vehicle applications is presented. A thermoelectric heat pump function regulates vehicular interior temperature environments and uses the waste heat from a vehicles engine to power thermocouples and generate supplemental electrical current to power electrical devices. Thermocouples are used to gauge changes in temperature. The Peltier Effect is used to provide both primary cabin environmental control and supplementary power generation for motorized vehicle applications. Thermoelectric generators can be used for both primary internal climate control and supplementary power generation in the vehicular environment.