Patents by Inventor Joseph Sisko

Joseph Sisko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing pyrano—[2,3-C]pyridine derivatives
    Patent number: 8759523
    Abstract: The present invention relates to a process comprising the step of dehydrating a compound of Formula (I): with a suitable dehydrating reagent to form a compound of Formula (II): wherein R1-R7 are as defined herein. Compounds of Formula (II) have shown promise as intermediates to compounds useful for treating bacterial infections.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: June 24, 2014
    Assignee: Glaxo Group Limited
    Inventors: Joseph Sisko, Douglas Mans, Hao Yin
  • PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVITAVES
    Publication number: 20130116436
    Abstract: The present invention relates to a process comprising the step of dehydrating a compound of Formula (I): with a suitable dehydrating reagent to form a compound of Formula (II): wherein R1-R7are as defined herein. Compounds of Formula (II) have shown promise as intermediates to compounds useful for treating bacterial infections.
    Type: Application
    Filed: July 19, 2011
    Publication date: May 9, 2013
    Inventors: Joseph Sisko, Douglas Mans, Hao Yin
  • Method for the synthesis of quinoline derivatives
    Publication number: 20060189809
    Abstract: This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (?)-(S)—N-(?-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.
    Type: Application
    Filed: April 28, 2006
    Publication date: August 24, 2006
    Inventors: Joseph Sisko, Mark Mellinger, Conrad Kowalski
  • Method for the synthesis of quinoline derivatives
    Publication number: 20050171152
    Abstract: This invention relates to novel intermediates and processes for preparing phamaceutically active quinoline compounds, including (?)-(S)-N-(?-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.
    Type: Application
    Filed: March 30, 2005
    Publication date: August 4, 2005
    Inventors: Joseph Sisko, Mark Mellinger, Conrad Kowalski
  • Novel compounds
    Publication number: 20020188122
    Abstract: Novel 1, 4, 5- substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Application
    Filed: February 27, 2001
    Publication date: December 12, 2002
    Applicant: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • Method for the synthesis of quinoline derivatives
    Patent number: 6335448
    Abstract: This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (−)-(S)-N-(&agr;-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.
    Type: Grant
    Filed: March 9, 2000
    Date of Patent: January 1, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Joseph Sisko, Mark Mellinger, Conrad Kowalski
  • Synthesis of intermediate compounds for 4-adyl-5-pyrimidine imidazole substituted derivatives
    Patent number: 6255491
    Abstract: The present invention relates to a method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a cycloaddition reaction.
    Type: Grant
    Filed: January 20, 1999
    Date of Patent: July 3, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
    Patent number: 6239279
    Abstract: The present invention relates to a novel method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a novel cycloaddition reaction.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: May 29, 2001
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Process for making pyridyl and pyrimidine substituted imidazole compounds
    Patent number: 6218537
    Abstract: 1,4,5,-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: April 17, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Compounds
    Patent number: 6150557
    Abstract: Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: November 21, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • Process of making tosylbenzyl formamide derivatives
    Patent number: 6103936
    Abstract: The present invention is to a novel process for the preparation of a compound of the formula: ##STR1## wherein p is 0, or 2;Ar is an optionally substituted phenyl or naphtyl; andinter alia R4 is an optionally susbtituted phenyl, naphth-1-yl, naphth-2-yl, or a heteroaryl ring;which process comprises reacting together an aldehyde of the formula:R.sub.4 --CHO;wherein R.sub.4 is as defined above;a compound of the formula:ArS(O)pH;wherein Ar, and p are as defined above;with formamide, an acid catalyst, and optionally a dehydrating agent.
    Type: Grant
    Filed: March 17, 1997
    Date of Patent: August 15, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravishanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • Synthesis for 4-aryl-5-pyrimidine imidazole substituted compounds
    Patent number: 6100399
    Abstract: The present invention relates to a method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a cycloaddition reaction.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: August 8, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Amide compounds
    Patent number: 5969184
    Abstract: The present invention is directed to the novel intermediate compounds of the formula: ##STR1## wherein, interalia, R.sub.4 is a substituted phenyl or an optionally substituted napthyl derivative.
    Type: Grant
    Filed: May 9, 1997
    Date of Patent: October 19, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Peter William Sheldrake, Timothy Francis Gallagher, Ravi Shanker Garigipati, Paul Elliot Bender, Jeffrey Charles Boehm, Joseph Sisko, Zhi-Qiang Peng, John C. Lee
  • 4-aryl-5-pyrimidine imiazole substituted compounds
    Patent number: 5917043
    Abstract: The present invention relates to a novel method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a novel cycloaddition reaction.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: June 29, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: Joseph Sisko
  • Process of preparing imidazole compounds
    Patent number: 5869660
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: February 9, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Imidazole compounds and compositions
    Patent number: 5739143
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: December 11, 1996
    Date of Patent: April 14, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm
  • Process for preparing pyrimidyl imidazoles
    Patent number: 5663334
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: September 2, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Peter William Sheldrake, Timothy Francis Gallagher, Joseph Sisko
  • Imidazole compounds, compositions and use
    Patent number: 5658903
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: August 19, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Jerry Leroy Adams, Timothy Francis Gallagher, Joseph Sisko, Zhi-Qiang Peng, Irennegbe Kelly Osifo, Jeffrey Charles Boehm